The invention discloses a high-precision vertical line deviation rapid measurement method integrating GNSS and CCD zenith tube, which shoots the zenith area by making the optical axis of the zenith tube point to the zenith direction at the station to obtain CCD Stellar images, and the image coordinates of the stars are calculated, the exposure epoch is controlled by the geodetic coordinates measured by GNSS and the GNSS time signal, combined with the vertical line deviation of the station calculated by the EGM2008 gravity field model, the zenith is obtained in the applicable star catalog Regional star information, realize the matching and identification of stars in the zenith tangent plane area of the celestial sphere in the star catalog and stars in the CCD star image, use the least square method to iteratively calculate the zenith astronomical coordinates, and combine the geodetic coordinates to calculate the vertical line deviation of the observation point. Compared with the prior art, the present invention has the advantages of simple operation, time-saving and labor-saving, and high measurement accuracy, and is suitable for rapid measurement of high-precision vertical line deviation.