The invention discloses a drum irradiation machine for intensively irradiating multiple X-ray source modules, and the concentrated irradiation drum irradiation machine can be used as special irradiation equipment for irradiating bagged blood or Chinese patent medicines and unpacked foods (such as garlic) and other samples. The equipment comprises concentrated irradiation combinations of multiple X-ray source modules, a sample drum rotating on a central turntable, a cylindrical irradiation chamber protection cover with a circular bottom, a circular irradiation chamber protection cover, the central turntable, an anode water cooling circulation system and a total control console; the drum irradiation machine operates in a way that said multiple X-ray source modules are intensively irradiated and the sample drum rotates in the direction perpendicular to the outgoing centre line of the X-ray source. The drum irradiation machine is high in radiation conversion efficiency, large in irradiation depth, and excellent in uniformity of irradiation dose, thus the drum irradiation machine is used for replacing a radioactive nuclear irradiation source blood irradiation machine widely used at present, finally, the irradiation equipment can completely get rid of the nuclear irradiation source, and potential menaces such as operators suffer from nuclear radiation caused by exchanging the sample drum and the surrounding environment generates the radioactive nuclear contamination can be eliminated.