The invention discloses a traditional Chinese medicine preparation for treating acute appendicitis and a preparation method of the traditional Chinese medicine preparation, belonging to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is composed of the following effective component raw materials: oriental stephania roots, Chinese lobelia herbs, vernonia, basella rubra, tender catchweed bedstraw herbs, sargentgloryvine stems, chickweeds, hypericum japonicum, cottonrose hibiscus leaves, ixeris japonica, feltwort, pennycress, glabrous sarcandra herbs, scutellaria scordifolia fisch. ex schrank, purslane and sow thistle. The medicinal materials selected by the traditional Chinese medicine preparation are proper in compatibility; the traditional Chinese medicine preparation conforms to the theories of traditional Chinese medicines and modern medicines, has the effects of clearing away heat and toxic materials, realizing antisepsis and anti-inflammation, inducing diuresis to alleviate edema as well as alleviating edema and expelling pus and is convenient to use, good in absorption effect and free of adverse and toxic or side effect; and proved by clinical verification, the traditional Chinese medicine preparation can be used for invigorating the blood circulation to remove blood stasis, regulating the middle warmer and appetizing, regulating the flow of Qi to alleviate pain and improving the inside and outside environments of an organism so as to treat and relieve various symptoms of acute appendicitis and be suitable for popularization and application of clinical treatment and nursing for acute appendicitis.