30results about How to "Promote tolerance" patented technology

The voice prompt of an interactive system is adjusted based upon a state of a user. An utterance of the user is received, and the state of the user is determined based upon signal processing of the utterance of the user. Once the state of the user is determined, the voice prompt is adjusted by adjusting at least one of a tone of voice of the voice prompt, a content of the voice prompt, a prosody of the voice prompt, and a gender of the voice prompt based upon the determined state of the user.

The voice prompt of an interactive system is adjusted based upon a state of a user. An utterance of the user is received, and the state of the user is determined based upon signal processing of the utterance of the user. Once the state of the user is determined, the voice prompt is adjusted by adjusting at least one of a tone of voice of the voice prompt, a content of the voice prompt, a prosody of the voice prompt, and a gender of the voice prompt based upon the determined state of the user.

Methods for sustained delivery of biologically active proteins or peptides to mammals are disclosed. Specific types of immune-privileged allogeneic or xenogenic donor cells that are naturally immune privileged are genetically modified in vitro to express or secrete the proteins or peptides. The genetically modified donor cells are subsequently implanted into host mammals and utilized for sustained delivery of biologically active proteins or peptides in vivo. The donor cells so utilized are those that inherently possess immune privilege due at least partly to the expression of Fas ligand. Methods for cell isolation, purification, tissue culture expansion, cryopreservation, gene transfer, transgene and Fas ligand expression, cell implantation, and measurement of immune responses of host animals are described.

A sport-boot pressure monitoring system and method of use. The system includes a left boot sensor having a left flexible fluid-containing bladder shaped to fit between a user's left leg and an interior surface of a left boot worn by the user and a left pressure sense element in pressure-sensing communication with the left flexible fluid-containing bladder, a right boot sensor that is similar to the left one, and a controller to provide a pressure alert if pressure between one of the user's legs and the interior surface of the boot worn on that leg violates a predetermined pressure threshold and to provide a proximity alert if a distance between the left and right boots violates a predetermined proximity threshold.

Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administratin of peptide MBP(75-95), MBP(86-95), or MBP(82-98) produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP(75-95), MBP(86-95), or MBP(82-98) resulted in significant decline of F and B CSF anti-MBP levels. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between amino acid 86 and amino acid 95.

A method of playing an educational group game for familiarizing the players with the concepts of teamwork, collaboration and responsibility, promoting tolerance and trust, self-esteem and leadership development, with respect to typical African culture and tradition. Following specific placement patterns, players of all cultural backgrounds and ages sit on the floor or at desks in a closed playing area. The purpose of the game is to move wooden blocks simultaneously, rhythmically and consistently among players within the closed area. Three to fifty players pick up the blocks in front of them, draw specific designs as instructed by the game facilitator, tap the blocks in front of their neighbors to the right or to the left and leave them there, while singing the accompanying song, under the guidance of the game facilitator who coordinates all major components of the game. Under great concentration, players challenge themselves not to accumulate more than one block in front of them at any time. The game presents numerous variations based on methods and outcomes, including a win-win outcome, a method of elimination, and a competitive but non-confrontational variation.

The present invention is based, at least in part, on the finding that tolerance can be induced by inhibition of CD4+ cells (and optionally CD8+ cells). Accordingly, the optimized dosing methods of the invention are useful in treating a primate, e.g., a human, by inhibiting CD4+ T cells to induce tolerance to at least one antigen, e.g., self or foreign, such as for inducting tolerance in a primate against a soluble or a cell bound antigen (e.g., an allogeneic or xenogeneic transplanted antigen).

A sport-boot pressure monitoring system and method of use. The system includes a left boot sensor having a left flexible fluid-containing bladder shaped to fit between a user's left leg and an interior surface of a left boot worn by the user and a left pressure sense element in pressure-sensing communication with the left flexible fluid-containing bladder, a right boot sensor that is similar to the left one, and a controller to provide a pressure alert if pressure between one of the user's legs and the interior surface of the boot worn on that leg violates a predetermined pressure threshold and to provide a proximity alert if a distance between the left and right boots violates a predetermined proximity threshold.

In one example, we describe a method and system for infant's development, which is a disc system, with various combinations and extensions. The brain is the only organ that constantly reorganizes itself based on experiences or lack thereof. Babies are born with millions of neurons. Through a process called “pruning”, certain ‘circuits’ are fine-tuned through repeated practice and stimulation. This occurs from birth, throughout early childhood. The purpose of the SensiMo Disc is to provide an infant, e.g., typically, up to the 25 lbs. and / or 29 inches long, sensorimotor stimulation, while lying in a prone or supine position, with minimal active movement of the head or extremities. As the child lays supine or proneon, on the SensiMo disc, the child's tactile, vestibular, and proprioceptive systems are stimulated. This helps develop the child's sensorimotor system. Many other variations and combinations, plus advantages, are discussed.

The invention discloses a composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising from 40 to 80 wt % of fucosylated oligosaccharide(s), from 10 to 50 wt % of N-acetylated oligosaccharide(s), from 5 to 40 wt % of sialylated oligosaccharide(s) and from 0 to 20 wt % of precursor(s) of human milk oligosaccharide, for use in preventing and / or in treating necrotizing enterocolitis in infants and young children.

A gene vector adapted for transient expression of a transgene in a peripheral organ cell comprising a regulatory sequence operably linked to a transgene wherein the regulatory sequence prevents or reduces expression of said transgene in hematopoietic lineage cells.

The invention discloses non-woven fabric having good glossiness and capable of releasing negative oxygen ions continuously and a preparation method of the non-woven fabric. The non-woven fabric is characterized by being prepared from raw materials in parts by weight as follows: 1-2 parts of silk fibers, 3-9 parts of tourmaline nanopowder, 1-2 parts of nylon fibers, 5-10 parts of polylactic acid, 1-2 parts of polyethylene glycol 200, 3-5 parts of activated carbon, 4-8 parts of mint essence, 2-4 parts of citronella oil, 60-80 parts of isotactic polypropylene, 3-6 parts of diatomite, 1-2 parts of sodium dodecyl sulfate, a proper amount of carboxymethyl cellulose sodium and a proper amount of water. The tourmaline nanopowder is added to the non-woven fabric, the effect of continuously releasing the negative oxygen ions can be realized, the space in a vehicle can be cool, comfortable and refreshing when the non-woven fabric is applied to automobile interior decoration, and the non-woven fabric has a remarkable refreshing effect after being matched with the mint essence; the added silk fibers can promote the target material to have the advantage of good glossiness.

Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administratin of peptide MBP(75-95), MBP(86-95), or MBP(82-98) produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP(75-95), MBP(86-95), or MBP(82-98) resulted in significant decline of F and B CSF anti-MBP levels. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between amino acid 86 and amino acid 95.

A wheel, having first and second bead seats which are inclined towards the outside and a cylindrical wall intended for supporting a support ring, constituted by the assembly of: a disc comprising a hub bearing surface, a transition zone and a radially outer edge, the geometry of which constitutes the first seat and a first part of the cylindrical wall, and a rim comprising a plurality of cavities and being such that its radially outer wall corresponds to the second seat and to the complementary part of the cylindrical wall; the assembly being effected at the end of the rim on the side of the disc at the level of the cylindrical wall, on one hand, and at the level of the end of the radially inner wall of the rim, on the other hand.

Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administration of peptide MBP75-95, either as a single dose, or as repeated injections for periods up to 10 weeks, produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP75-95 resulted in significant decline of F and B CSF anti-MBP levels over a period of one month. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between Pro85 and Pro96.

The invention discloses a mosquito-repelling non-woven fabric capable of continuously releasing negative oxygen ions and a preparation method thereof. The non-woven fabric is characterized by being prepared from, by weight, 1-3 parts of diethyl(meta)toluamide, 4-8 parts of nano-tourmaline powder, 2-4 parts of cedar oil, 5-10 parts of polylactic acid, 1-2 parts of polyethylene glycol 200, 3-5 parts of activated carbon, 4-8 parts of mint essence, 1-3 parts of pure cotton fibers, 50-70 parts of isotactic polypropylene, 3-6 parts of kieselguhr, 1-2 parts of sodium dodecyl sulfate and a proper amount of carboxymethyl cellulose sodium and water. The nano-tourmaline powder is added into the non-woven fabric, and consequently the effect of continuously releasing negative oxygen ions can be achieved; when the non-woven fabric is applied to automotive trims, people can feel coolm comfortable and refreshing in the space in an automobile; the mint essence is added in a matched mode, and the refreshing effect is remarkable; diethyl(meta)toluamide is added in a matched mode, and the effect of repelling mosquitoes is endowed to a target material.

The invention discloses a disinsecting non-woven fabric capable of continuously releasing negative oxygen ions, and a preparation method thereof; the non-woven fabric is characterized by comprising the following raw materials by weight parts: pyrethrin 3-5 parts, nanometer tourmalinite powder 4-8 parts, zinc oxide 1-2 parts, polylactic acid 5-10 parts, polyethylene glycol 200 2-3 parts, active carbon 3-5 parts, mint essence 4-8 parts, bamboo powder 1-3 parts, isotatic polypropylene 50-70 parts, diatomite 4-8 parts, sodium dodecanesulphonate 1-2 parts, proper amount of hydroxymethyl cellulose sodium and proper amount of water; the nanometer tourmalinite powder is added in the non-woven fabric so as to continuously release negative oxygen ions; the non-woven fabric can be applied to the vehicle trim, so the vehicle inner space can be fresh and comfortable, and refreshing; the mint essence is added so as to provide obvious spirit raising effect; the pyrethrin is added, thus allowing the target material to have disinsecting function.

SO-transgenic plants overexpressing or lacking SO activity, having modified tolerance or susceptibility to toxicity of sulfite-producing substances, methods for their production and the use thereof for bioremediation of pollutants, as sentinel plants, for enhancing post-harvest quality of plants, plant tissues and plant products and for therapeutic applications.

The invention discloses a non-woven fabric containing shell powder and having a function of continuously releasing negative oxygen ions and a preparation method thereof. The non-woven fabric is characterized by being prepared from the following raw materials in parts by weight: 1 to 2 parts of shell powder, 4 to 8 parts of nanometer tourmaline powder, 1 to 2 parts of quartz, 4 to 9 parts of polylactic acid, 1 to 2 parts of polyethylene glycol 200, 3 to 5 parts of active carbon, 5 to 9 parts of peppermint essence, 1 to 3 parts of olive oil, 50 to 70 parts of isotatic polypropylene, 3 to 6 parts of diatomite, 1 to 2 parts of sodium dodecyl sulfate, a proper amount of sodium carboxymethyl cellulose and a proper amount of water. The nanometer tourmaline powder is added into the non-woven fabric, so that the effect of continuously releasing the negative oxygen ions can be achieved; when the non-woven fabric is applied to automotive interiors, the internal space of an automotive can become clear, comfortable and refreshed; through use of the peppermint essence, a remarkable refreshing effect is achieved; the shell powder and the like are applied, so that the non-woven fabric is easy to prepare, and is low in production cost.

In one example, we describe a method and system for infant's development, which is a disc system, with various combinations and extensions. The brain is the only organ that constantly reorganizes itself based on experiences or lack thereof. Babies are born with millions of neurons. Through a process called “pruning”, certain ‘circuits’ are fine-tuned through repeated practice and stimulation. This occurs from birth, throughout early childhood. The purpose of the SensiMo Disc is to provide an infant, e.g., typically, up to the 25 lbs. and / or 29 inches long, sensorimotor stimulation, while lying in a prone or supine position, with minimal active movement of the head or extremities. As the child lays supine or proneon, on the SensiMo disc, the child's tactile, vestibular, and proprioceptive systems are stimulated. This helps develop the child's sensorimotor system. Many other variations and combinations, plus advantages, are discussed.

The invention discloses a flame-retardant and anti-corrosion non-woven fabric capable of continuously releasing negative oxygen ions and a preparation method thereof. The fabric is characterized by being prepared from, by weight, 2-4 parts of gypsum, 3-7 parts of bamboo filament fiber powder, 2-3 parts of talcum powder, 4-8 parts of nanometer tourmaline powder, 4-9 parts of a PAMAM solution, 5-10 parts of polylactic acid, 1-2 parts of polyethylene glycol, 2-5 parts of microcrystalline wax, 3-5 parts of activated carbon, 4-8 parts of mint essence, 10-15 parts of a sodium periodate solution, 50-70 parts of isotatic polypropylene, 3-6 parts of kieselguhr, 1-2 parts of sodium dodecyl sulfate, a proper amount of carboxymethyl cellulose sodium and a proper amount of water. The nanometer tourmaline powder is added into the non-woven fabric, the effect of continuously releasing negative oxygen ions can be achieved, and the non-woven fabric has the effects of calming, analgesia, cough relief, itching relief, appetite increase and blood pressure reduction; due to the fact that gypsum and talcum powder are added, the target material has the advantages of retarding flames and resisting corrosion.

Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administratin of peptide MBP(75-95), MBP(86-95), or MBP(82-98) produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP(75-95), MBP(86-95), or MBP(82-98) resulted in significant decline of F and B CSF anti-MBP levels. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between amino acid 86 and amino acid 95.

In one example, we describe a method and system for infant's development, which is a disc system, with various combinations and extensions. The brain is the only organ that constantly reorganizes itself based on experiences or lack thereof. Babies are born with millions of neurons. Through a process called “pruning”, certain ‘circuits’ are fine-tuned through repeated practice and stimulation. This occurs from birth, throughout early childhood. The purpose of the SensiMo Disc is to provide an infant, e.g., typically, up to the 25 lbs. and / or 29 inches long, sensorimotor stimulation, while lying in a prone or supine position, with minimal active movement of the head or extremities. As the child lays supine or proneon, on the SensiMo disc, the child's tactile, vestibular, and proprioceptive systems are stimulated. This helps develop the child's sensorimotor system. Many other variations and combinations, plus advantages, are discussed.

The invention discloses a composition comprising an oligosaccharide mixture, said oligosaccharide mixture comprising from 40 to 80 wt % of fucosylated oligosaccharide(s), from 10 to 50 wt % of N-acetylated oligosaccharide(s), from 5 to 40 wt % of sialylated oligosaccharide(s) and from 0 to 20 wt % of precursor(s) of human milk oligosaccharide, for use in preventing and / or in treating necrotizing enterocolitis in infants and young children.

The present invention includes modified and unmodified microbes, compositions comprising these microbes, and methods of using these microbes and / or compositions for enhancing plant health, plant growth plant yield and / or drought tolerance. This disclosure also provides non-naturally occurring plant varieties that are artificially infected with microbes descried herein, as well as seed, reproductive tissue, vegetative tissue, regenerative tissues, plant parts, or progeny thereof.

The present invention relates to a composition comprising at least one human milk oligosaccharide and / or a precursor thereof, for use in preventing and / or treating necrotizing enterocolitis in infants or young children born by C-section.

In one example, we describe a method and system for infant's development, which is a disc system, with various combinations and extensions. The brain is the only organ that constantly reorganizes itself based on experiences or lack thereof. Babies are born with millions of neurons. Through a process called “pruning”, certain ‘circuits’ are fine-tuned through repeated practice and stimulation. This occurs from birth, throughout early childhood. The purpose of the SensiMo Disc is to provide an infant, e.g., typically, up to the 25 lbs. and / or 29 inches long, sensorimotor stimulation, while lying in a prone or supine position, with minimal active movement of the head or extremities. As the child lays supine or proneon, on the SensiMo disc, the child's tactile, vestibular, and proprioceptive systems are stimulated. This helps develop the child's sensorimotor system. Many other variations and combinations, plus advantages, are discussed.

Human myelin basic protein (h-MBP) has a molecular weight of 18.5 KD and contains 170 amino acid residues. Synthetic peptides ranging in length from about 8 to 25 residues and covering the entire length of the protein have been produced. Antibodies to h-MBP (anti-MBP) were found to be neutralized by the synthetic peptides, in vitro, which span the h-MBP from about amino acid residue 61 to about amino acid residue 106. The peptides, which cover both the amino (about residues 1 to 63) and carboxy (about residues 117 to 162) terminals of h-MBP did not neutralize purified anti-MBP. Intrathecal administration of peptide MBP75-95, either as a single dose, or as repeated injections for periods up to 10 weeks, produced complete binding-neutralization of free (F) anti-MBP with no change in bound (B) levels. A control peptide MBP35-58 had no effect on F or B anti-MBP levels. Intravenous administration of MBP75-95 resulted in significant decline of F and B CSF anti-MBP levels over a period of one month. Administration of MBP synthetic peptides to MS patients either intrathecally or intravenously did not have any adverse neurological effects and systemic complications did not occur. The MBP epitope for MS anti-MBP has been localized to an area between Pro85 and Pro96.

A gene vector adapted for transient expression of a transgene in a peripheral organ cell comprising a regulatory sequence operably linked to a transgene wherein the regulatory sequence prevents or reduces expression of said transgene in hematopoietic lineage cells.