The invention discloses a preparation method of a quick-acting medicinal composition for killing borer worms, which comprises the following steps: 1) preparing raw materials; 2) decocting camphor, succulents, and rhizomes with water twice, and preparing the medicinal liquid for later use; 3) Qianli Add water to decoct the light, green betel, cypress, Xu Changqing, herringbone grass, and zebra leaves twice, filter, and concentrate the filtrate to a relative density of 1.8; 4) Combine the liquid medicine; 5) Adjust the pH value of the solution; 6) Filter, fill, sterilize, and get ready. The pharmaceutical composition described in the present invention can kill borer worms in a targeted manner, has good safety, good biodegradation, no pollution and irritating odor, no environmental toxicity, no residue in animals, does not destroy ecological balance, and is beneficial to The crop growth environment has little impact; it has good permeability and moisture, interferes with the central nervous system of insects, inhibits the synthesis and development of insect eggs, and is not easy to develop drug resistance; it has good quick effect and is suitable for widespread application in pest control.