69results about How to "Minimizing penetration" patented technology

The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising:i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof;ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof;iii. a surface-active agent;iv. about 0% to about 5% by weight of at least one polymeric agent; andv. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition;wherein the composition is housed in a container and is substantially flowable, andwhich upon release expands to form a breakable foam; andwherein the foamable carrier is selected to generate a foam of good to excellent quality.The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.

Notched, surface-mounted wall anchors and anchoring systems employing the same are disclosed. The anchor is a notched, folded sheetmetal construct utilizable with various wire formative veneer ties. The depth of the notch is greater than the combined thickness of the wallboard and the waterproofing layer. Various embodiments show wall anchor configurations with suitable veneer ties and differing sheathing arrangements. The notches, upon surface-mounting of the wall anchor, form small wells in the portion of the notch extending into the insulation, which wells entrain water vapor, condensate and water, and relieve the same from being driven into the wallboard.

Electronic displays are physically reshaped and / or resized to meet custom specifications for special applications such as avionics, where Commercial Off-The-Shelf (COTS) Liquid Crystal Displays (LCDs) are not typically used. Customization includes cutting the physical display to specified dimensions to fit into a target opening, and resealing the display to preserve proper cell spacing and assure basic functionality. The target opening is typically a control panel or dashboard opening, such as in the cockpit of an airplane. The sealing process may include improving the original seal, and / or providing additional seals. Additional seals may protect sensitive areas against chemical corrosives or contamination, humidity, electrostatic damage, etc., and / or prevent light from passing around the edge of the display image area. Electric continuity may need to be reestablished for electric leads affected during the customization process, and electronic drivers may need to be reattached to the display. Additional modifications and / or enhancements may be made to the display during reshaping and / or resizing. For example, TABs or COGs may be relocated, added, removed, replaced, and / or reoriented; electric circuits may be replaced and / or supplemented with circuits having different functionality; the display medium may be altered and / or replaced; polarizers, filters, and / or films may be added, removed, and / or replaced. The customized display may then be ruggedized by attaching a suitable bezel (face plate) and frame (support hardware) thereto, and the completed, customized display unit may then be installed in the target location and integrated with surrounding hardware and electronics.

A wheel assembly includes a rigid wheel and an airless tire configured to present some performance characteristics of a pneumatic tire. The wheel includes a pair of radially outermost axially spaced rim portions, each rim portion including a transversely flat outer surface extending at least partially around the circumference of the wheel. The tire is mounted on the wheel such that the tire engages the outer surfaces of the rim portions of the wheel. A central portion of the tire is configured to flex inwardly between the rim portions of the wheel in response to ground engaging pressure, thus minimizing ground penetration and soil disturbance during use.