The invention discloses a liver and gall drainage tube which comprises a drainage tube body, one end of the drainage tube body is communicated with a drainage device, the bottom of the drainage device is connected with a liquid drainage tube, the liquid drainage tube is provided with a liquid drainage valve, the end, away from the drainage device, of the drainage tube body is connected with a puncture head, and the tip end of the puncture head is provided with a puncture head opening. A medicine guide tube is fixedly arranged on the inner side face of the drainage tube body, a plurality of medicine guide holes are formed in the medicine guide tube, a medicine inlet tube communicated with the medicine guide tube is arranged on the outer side face of the drainage tube body, a medicine inlet is formed in the top of the medicine inlet tube in a connected mode, and a medicine inlet cover is detachably arranged on the medicine inlet. A plurality of elastic support plates are arranged in the drainage tube body between the puncture head and the medicine guide tube, and drainage ports are formed among the elastic support plates. The drainage tube has the following advantages that the drainage efficiency is high, the drainage speed is high, liquid medicine can be added into the drainage tube, the treatment effect can be achieved, the puncture head is combined with the drainage tube, and the pain caused by multiple times of puncture is avoided.