The invention relates to the field of concave-convex advertising board printing devices, in particular to a concave-convex advertising board printing device. The concave-convex advertising board printing device comprises a main body, a discharging port, a material transferring mechanism, a flattening mechanism, a conveying mechanism, a printing mechanism, an opening and closing mechanism and a limiting mechanism. Materials needing to be printed with concave-convex characters can be conveniently transferred to a next stage one by one through the arrangement of the material transferring mechanism, flattening and straightening treatment can be conducted on the raw materials through the arrangement of the flattening mechanism, edge warping of the printed materials is avoided, and the adjusted materials can be conveyed to the bottom end of the printing mechanism through the arrangement of the conveying mechanism. Through the arrangement of the printing mechanism, materials conveyed by the conveying mechanism can be conveniently pressed, through the arrangement of the opening and closing mechanism, when the main body is idle, a filling opening of the main body can be shielded, dust is prevented from entering the main body, and through the arrangement of the limiting mechanism, a shielding part can be automatically limited. The working process is prevented from being influenced by accidental sliding of the shielding part, and the use effect of the main body is improved.