A real-time automated data security system protects both data and devices from loss, theft, and unauthorized access or activity. A miniature active RFID circuit is embodied in tags, area tags, controllers, USB sticks and a universal interface software for computers (i.e., Java), smart phones, and gateway boxes written to interface with the system. These devices are customizable and can link in arrays to cover large areas, use sensors, and scale up in module configurations to meet any need. The system is independent of electricity, GPS, satellites, the Internet, other software, and IT personnel. Its novel software, inside the tags, area tags and controllers is inaccessible and cannot be copied. Wireless transmissions are encrypted to military grade levels and packets are never repeated, making it unhackable, even by brute force attack. A unique battery-conserving protocol ensures good range and long battery life. The system has the ability to ignore copied packages or relaying by attackers, and to prevent of unauthorized access to USB sticks by proximity checks to the active RFID circuit.