The invention discloses an orthopedic Kirschner wire positioning guide with a quick-lock switch, which includes an operating table, a lifting unit, a steering unit, and a guiding unit. The lifting unit includes a supporting sleeve, an adjustment rod, a lifting sleeve, and a quick-locking switch. The side wall of the lifting sleeve is made with a connecting seat, and a quick lock switch is assembled on the connecting seat. The steering unit includes a cylinder body, and the lower gasket, sphere, upper gasket, locking block, cover plate, locking Knob assembly, the cylinder body is provided with a first fixed arm, the end of which is provided with a guide ring, the guide ring is connected and fixed with the upper end of the adjustment rod, the lower end of the ball is provided with a second fixed arm, and the lower end of the second fixed arm is provided with a sleeve The guide unit includes a guide target sleeve, a sliding arm integrated with the guide target sleeve, and a guide sleeve. The slide arm can be movably inserted in the sleeve, with reasonable design, accurate positioning, and suitable for needle insertion and fixation in various directions. Effectively prevent the deviation of the Kirschner wire when it penetrates into the human body.