The invention relates to a rapid and simple frame alignment device for a silk screen frame. The rapid and simple frame alignment device comprises the horizontally-arranged silk screen frame, a front arm clamping mechanism and a back arm clamping mechanism, wherein the front arm clamping mechanism and the back arm clamping mechanism are connected with the front side and the back side of the silk screen frame correspondingly; the front arm clamping mechanism comprises a vertical direction adjusting part and a horizontal direction adjusting part, a front-back adjusting rod and a left-right adjusting rod in the horizontal direction adjusting part drive a left-right adjusting sliding block to achieve front-back adjustment and left-right adjustment in a bracket correspondingly, and a perpendicular air cylinder in the vertical direction adjusting part cooperates with a vertical guide rail and a front fine adjustment adjusting rod to achieve up-down adjustment; and the back arm clamping mechanism can be coincident with the front arm clamping mechanism in structure, and can also be a follow-up structure composed of a fixing abutting block, a left-right follow-up sliding block and a front-back adjusting air cylinder. The design is wide in adjusting scope, high in accuracy, capable of achieving rotary adjustment and good in adjusting effect; and in addition, starting elements are fewer, the adjusting speed is higher, the structure is simple, the manufacturing cost is lower, the printing color registering accuracy is better improved, and the printing effect is greatly improved.