The invention relates to vehicle interior active noise cancellation. A vehicle has an electric drive mode, a body defining a vehicle interior, a first and second set of audio speakers positioned outside and inside of the interior, respectively, and a controller. The controller generates an acoustic signal, broadcasts the acoustic signal via the first set of speakers during an electric drive mode,and generates and broadcasts a cancelling signal via the second set of speakers. The broadcasts are coordinated to substantially cancel an attenuated portion of the acoustic signal resulting from propagation of the acoustic signal into the interior. A method cancels a synthesized sound within a vehicle interior by collecting vehicle operating values, generating an acoustic signal as the synthesized sound during an electric drive mode, and processing the acoustic signal to generate a modified acoustic signal approximating an attenuated portion of the acoustic signal propagating into the vehicle interior.