154results about "Chemoinformatics" patented technology

A system and method is provided for using a communications network coupling a plurality of computer systems, a database, and a at least one external data source together to facilitate communication therebetween. The plurality of computer systems is configured to extract at least one term from a medical order for the patient, identify at least one medical concept related to an extracted term, and identify at least one medical data element related to an identified medical concept. The plurality of computer system is further configured to query the database for the identified at least one medical data element, query the at least one external data source to retrieve at least one guideline for performing at least one intervention associated with the at least one medical data element, and generate a user interface that displays at least a portion of a result from the queries.

A system and method for targeting relevant research activity for clinical application in response to diagnostic markers analyses is described. Diagnostic analysis is performed to detect the level of each of at least three diagnostic markers. The levels of the tested markers are used to identify relevant publications from among a large database of articles. The most relevant literature, such as, one which reports research and studies that have been conducted to identify, moderate, and define the mechanisms unique to individual and combinations of diagnostic markers for various disease states, is then provided to the patient and/or the patient's physician, optionally with a summarization of the treatment recommendations from the provided literature. The customized information delivery provides a range of published peer-reviewed therapeutic options and/or published research studies.

The invention relates to a comprehensive evaluation method of underground water, wherein the method includes steps of a, re-classifying the classification dividing value of seventeen water quality indexes such as manganese, fluoride, monoiodide and mercury in the underground water quality; b, selecting the water quality index participated in rating according to the testing index of the underground water sample, and substituting the testing result of the underground water sample and the classification dividing value of the selected water quality index participated in the evaluation to a membership function, and calculating and acquiring a fuzzy membership matrix; c, performing data conversion on a toxic index of the water quality index; d, according to the converted toxic index, the sample testing result, and the classification dividing value of the water quality index, calculating a weight matrix; e, coupling the fuzzy membership matrix with the weight matrix, and acquiring the evaluation result matrix and the evaluation grade of the underground water quality. The evaluation result fully considers about the risk of the human body health, and can comprehensively evaluate the underground water quality from the view of the human body health risk; the evaluation result can further objectively reflect the drinking safety.

The present disclosure describes gene signature biomarkers that are useful for identifying cancer patients who are most likely to benefit from treatment with a PD-1 antagonist. The disclosure also provides methods and kits for testing tumor samples for the biomarkers, as well as methods for treating subjects with a PD-1 antagonist based on the test results.

The invention provides a response surface method for optimizing extraction process of red-fleshed pitaya peel anthocyanin. The peel of red-fleshed pitaya is taken as a raw material, a single-factor experimental method is utilized for exploring the effects of ethanol concentration, extraction time, extract liquid pH value and extraction temperature on the red-fleshed pitaya peel anthocyanin, the ethanol concentration, extract liquid pH value, extraction temperature and extraction time are taken as influence factors, the extracting solution absorbance of the red-fleshed pitaya peel anthocyanin is taken as a response value, a central combined experiment is utilized for mathematical modeling, the optimal ethanol concentration, extract liquid pH value, extraction temperature and extraction time of the red-fleshed pitaya peel anthocyanin are determined through the analysis of a response surface, and the extraction volume of the obtained anthocyanin is 58.9 mg/g. According to the response surface method, the benefits can be improved, the pollution of the peel to the environment can be reduced, and the value of pitaya is improved.

Provided herein is technology for hepatocellular carcinoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of hepatocellular carcinoma.

Provided is a parental genome assembly method, comprising: using the sequencing data of parental selfing line progeny population to assemble and perfect the parental genome data. Also provided is a device for implementing the method.

The present invention relates to a method for producing a three-dimensional characteristic model of a rock sample for analysis of the spatial and physical characteristics of materials subsequent to the processing of images obtained by means of computer tomography. The method includes producing a three-dimensional tomographic image of a sample of material, identifying areas where the structure of the material is homogeneous, assigning a particular material density value to each such area, assigning a particular porosity value to each pixel, assigning a particular absolute permeability value to each pixel, forming a three-dimensional characteristic model on the basis of the porosity and permeability values of each pixel, and calculating the absolute permeability of the entire sample or of a portion thereof in any direction by means of computational fluid dynamics. The technical result is an increase in the precision and reliability of data obtained regarding the permeability characteristics of a sample of porous material, without the need to employ additional financial and labor resources.

A new method for encoding genomic data that reduces storage footprint by two orders of magnitude while preserving acceptable quality data.

A system and method are introduced for simulating the particulate physical systems governed by population balance equations with particle splitting (breakage) and aggregation based on accurately conserving an unlimited number of moments associated with the particle size distribution. The basic idea is based on the concept of primary and secondary particles, where the former is responsible for the distribution reconstruction while the latter one is responsible for different particle interactions such as splitting and aggregation. The system and method are found to track accurately any set of low-order moments with the ability to reconstruct the shape of the distribution.

A method for accelerating searches for optimal control of photonic reagents is provided. Closed loop feedback is applied to control a quantum system. A direct search deterministic technique is used for refining said closed loop feedback control. A quantum system controller is also provided.

The invention belongs to the technical field of water quality safety evaluation and particularly relates to a water quality criterion derivation method for human health protection and a safety evaluation method of water quality of a drinking water source region. When whether certain water quality is safe is evaluated, the carcinogenic effect acting mode of a pollutant is judged firstly, water quality criterion values for human health protection are calculated by use of corresponding derivation formulas according to the carcinogenic effect acting mode, then, the concentration value of pollution matter of the to-be-detected drinking water source region is detected, if the concentration value is lower than the water quality criterion value, the quality of drinking water is safe, and otherwise, the quality is not safe. The provided water quality criterion derivation method is simple, the derivation result error is small, the pertinence is high, and a theoretical basis is provided for the environmental protection department to set the water quality standard of drinking water for human health protection.

The pedometer is equipped with a physical activity amount-acquiring unit (11) that acquires the amount of physical activity of the person being measured, an indicator-acquiring unit (15) that acquires an indicator pertaining to the amount of physical activity, and an indicator-outputting unit (18) that outputs the acquired indicator. The indicator-acquiring unit (15) comprises a physical activity age-acquiring unit (16) for acquiring, using somatic information about the person being measured, the physical activity age, which represents the standard age of people having the same amount of physical activity as the amount of physical activity acquired in a unit period of time. An indicator for achieving a target physical activity age is acquired on the basis of the acquired physical activity amount.

The invention relates to an accelerating simulating method capable of overcoming rapid migration of surface species in heterogeneous catalysis. The accelerating simulating method comprises the following steps: 1) starting to simulate and initializing a catalyst crystal mesh model; 2) dividing events in the heterogeneous catalysis process into rapid events and slow events; 3) traversing surface sites for matching events, establishing a corresponding slow event probability list for a slow event list, and adopting a roulette algorithm for selecting a present iterative event; 4) performing VSSM canonical algorithm on the slow event probability list, thereby performing system boosting simulation, including selecting events and reaction sites, boosting system time, re-matching local environmentand updating the event list; 5) redistributing quick migrating species for quick events and updating the surface configuration; 6) repeating the step 4) till achieving the maximal iteration steps or the maximal system boosting time, and then performing data post-processing and ending. Compared with the prior art, the accelerating simulating method provided by the invention has the advantages of high practicability, quickness in boosting, physical significance, and the like.