53 results about "Retinal function" patented technology

Biocompatible intraocular microspheres and implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to treat or to prevent the occurrence of one or more ocular conditions, to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like, to enhance normal retinal function and / or to lower intraocular pressure.

A system and method for obtaining information about the spatial distribution of photoreceptor activity and neural activity in the retina using simultaneously recorded multiple biopotential signals. The information thus gathered is used to assess retinal dysfunction due to trauma or disease. The biopotential signals are recorded from the surface of the eye and head using a plurality of electrodes, including those integral to a contact lens. The biopotential signals are recorded before, during and after the presentation of an optical stimulus to the subject eye. The recorded biopotential signals are then analyzed and interpreted to reveal the distribution of photoreceptor activity and neural activity across the retina. The analysis and interpretation of the biopotential signals is quantitative, and makes use of an electromagnetic model of the subject eye. The subject may be animal or human.

Systems and methods are provided for improving overall vision in patients suffering from a loss of vision in a portion of the retina (e.g., loss of central vision) by providing symmetric or asymmetric optic with aspheric surface which redirects and / or focuses light incident on the eye at oblique angles onto a peripheral retinal location. The intraocular lens can include a redirection element (e.g., a prism, a diffractive element, or an optical component with a decentered GRIN profile) configured to direct incident light along a deflected optical axis and to focus an image at a location on the peripheral retina. Optical properties of the intraocular lens can be configured to improve or reduce peripheral errors at the location on the peripheral retina. One or more surfaces of the intraocular lens can be a toric surface, a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface to reduce optical errors in an image produced at a peripheral retinal location by light incident at oblique angles.

The present invention provides an electrode array device for simultaneously detecting electrical potentials at five or more locations on the anterior surface of an eye. The device comprises a dielectric lens substrate having a concave inner surface conforming to the anterior surface of the eye, and at least five recording electrodes positioned in relation to the inner surface of the lens substrate so as to make electrical connection with the anterior surface of the eye when the lens substrate is placed on the anterior surface of eye. Each recording electrode is in electrically conductive communication with a corresponding conductive contact, there being one conductive contact for each recording electrode. Each conductive contact is adapted for operable connection to signal processor, and each conductive contact is electrically insulated from the anterior surface of the eye. A computational method for analyzing electrophysiological potentials recorded at five or more locations on the anterior surface of the eye, which reflect the spatial distribution of activity of the retina, is also provided.

An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

An Optical Imaging Device of Retinal Function has been developed to detect changes in reflectance of near infrared light from the retina of human subjects in response to visual activation of the retina by a pattern stimulus. The measured changes in reflectance correspond in time to the onset and offset of the visual stimulus in the portion of the retina being stimulated. Any changes in reflectance can be measured by interrogating the retina with a light source. The light source may be presented to the retina via the cornea and pupil or through other tissues in and around the eye. Different wavelengths of interrogating light may be used to interrogate various layers of the retina. Additionally, various novel patterns and methods of stimulation have been developed for use with the imaging device and methods.

The invention provides a method for increasing the magnification of a lens without changing the dioptric power. The method of the invention uses a measurement or an estimate of an individual's retinal function in designing the lens to provide the magnification needed by the individual without increasing the dioptric power of the individual's lens.

Retinal metabolism is analysed with a retinal function camera over at least a portion of a cardiac cycle by first illuminating a portion of a retina of an eye 10 with light of a first wavelength and producing a first image. The portion of the retina is subsequently illuminated with light of a second wavelength, the first and second wavelengths being selected such that absorptivity of light of the first wavelength by oxygenated blood is greater than absorptivity of light of the second wavelength and the absorptivity of light of the first wavelength by deoxygenated blood is less than absorptivity of light of the second wavelength, to produce a second image. The first and second images are processed to map relative oxygenation of the portion of the retina as an indication of retinal metabolic function of the portion of the retina. The procedure is repeated over at least a portion of a cardiac cycle to analyse metabolic function changes of the portion of the retina within the at least a portion of a cardiac cycle. In some embodiments at least a portion of the retina is subjected to optical stimulation and effects of the optical stimulation on retinal metabolic function analysed.

Systems and methods are provided for improving overall vision in patients suffering from a loss of vision in a portion of the retina (e.g., loss of central vision) by providing an enhanced toric lens which redirects and / or focuses light incident on the eye at oblique angles onto a peripheral retinal location. The intraocular lens can include a redirection element (e.g., a prism, a diffractive element, or an optical component with a decentered GRIN profile) configured to direct incident light along a deflected optical axis and to focus an image at a location on the peripheral retina. Optical properties of the intraocular lens can be configured to improve or reduce peripheral errors at the location on the peripheral retina. One or more surfaces of the intraocular lens can be a toric surface, a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface to reduce optical errors in an image produced at a peripheral retinal location by light incident at oblique angles.

A method of measuring retinal or visual pathway function comprises stimulating optokinetic nystagmus by presenting a visual stimulus to a patient; modifying a first parameter of the visual stimulus; modifying a second parameter of the visual stimulus; and using the modified visual stimulus to determine a threshold stimulus for optokinetic nystagmus; wherein the first and second parameters are selected from a group of parameters comprising a pattern for the visual stimulus, a width of the visual stimulus, a distance between the visual stimulus and the patient, a spatial frequency of the visual stimulus, a rate of change or temporal frequency of the test face of the visual stimulus, and a contrast between elements of the visual stimulus.

Systems and methods are provided for improving overall vision in patients suffering from a loss of vision in a portion of the retina (e.g., loss of central vision) by providing a dual optic intraocular lens which redirects and / or focuses light incident on the eye at oblique angles onto a peripheral retinal location. The intraocular lens can include a redirection element (e.g., a prism, a diffractive element, or an optical component with a decentered GRIN profile) configured to direct incident light along a deflected optical axis and to focus an image at a location on the peripheral retina. Optical properties of the intraocular lens can be configured to improve or reduce peripheral errors at the location on the peripheral retina. One or more surfaces of the intraocular lens can be a toric surface, a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface to reduce optical errors in an image produced at a peripheral retinal location by light incident at oblique angles.

The invention provides a method for increasing the magnification of a lens without changing the dioptric power. The method of the invention uses a measurement or an estimate of an individual's retinal function in designing the lens to provide the magnification needed by the individual without increasing the dioptric power of the individual's lens.

A system and method for assessing the functionality of a visual system, especially b generate a coded pattern which is illuminated by the light source. Optics project an image of the coded pattern onto the retina of the eye. The sensor detects electrical signals based on the response of the visual system to the image. One or more processors control the DMD and correlate the electrical response from the sensor with the coded DMD pattern to assess the functionality of the visual system.

Retinal metabolism is analyzed with a retinal function camera over at least a portion of a cardiac cycle by first illuminating a portion of a retina of an eye 10 with light of a first wavelength and producing a first image. The portion of the retina is subsequently illuminated with light of a second wavelength, the first and second wavelengths being selected such that absorptivity of light of the first wavelength by oxygenated blood is greater than absorptivity of light of the second wavelength and the absorptivity of light of the first wavelength by deoxygenated blood is less than absorptivity of light of the second wavelength, to produce a second image. The first and second images are processed to map relative oxygenation of the portion of the retina as an indication of retinal metabolic function of the portion of the retina. The procedure is repeated over at least a portion of a cardiac cycle to analyze metabolic function changes of the portion of the retina within the at least a portion of a cardiac cycle. In some embodiments at least a portion of the retina is subjected to optical stimulation and effects of the optical stimulation on retinal metabolic function analyzed.

An apparatus, system or method for aiding the vision of visually impaired individuals having a retina with reduced functionality, which overcomes the drawbacks of the background art by overcoming such reduced and / or uneven retinal function.

It is intended to provide a novel therapeutic method for a disease with apoptotic degeneration in eye tissue cells such as retinal pigment degeneration. Attention was paid on the concomitant administration of two neurotrophic factors: pigment epithelium-derived factor (PEDF) and fibroblast growth factor 2 (FGF2). The sites of actions are considered to be different between PEDF and FGF2. An SIV-PEDF vector and an SIV-FGF2 vector were constructed and administered to the subretinal space of an RCS rat, which is a disease model of retinal pigment degeneration, and their effects were evaluated. At 4 weeks, 8 weeks and 12 weeks after the administration of the vectors, a significantly higher visual cell protection effect was obtained in a group with concomitant administration than in a group with sole administration. Further, the functional evaluation of retina was carried out by electroretinogram and an effect in the group with concomitant administration was significantly higher than in the group with sole administration. From the above results, it was found for the first time that the concomitant administration of PEDF and FGF2 has higher effects in the treatment of retinal pigment degeneration than conventional methods.

The invention discloses a panretinal optical function imaging system comprising a stimulation light source and an optical element part thereof, an infrared illumination light source and an optical element part thereof, a double-ellipsoid optical element part and a retinal infrared image signal processing part, wherein the double-ellipsoid optical element part comprises a transverse ellipsoid reflector and a longitudinal ellipsoid reflector; one focal point of the longitudinal ellipsoid reflector and an eyeball node intersect at a point F3; the other focal point of the longitudinal ellipsoid reflector coincides with one external focal point F2 of the transverse ellipsoid reflector; the connection line of the external focal point F2 of the transverse ellipsoid reflector and the focal point F3 of the longitudinal ellipsoid reflector forms a rotation axis; and the optical elements of the whole optical imaging system rotates around the rotation axis Z. The panretinal optical function imaging system has the advantages of high scanning efficiency, short time, low image noise and high resolution, the functions of different kinds of photoreceptors can be detected and distinguished, and interference generated by the environment and electronic instruments can be reduced. The panretinal optical function imaging system can be used for objectively detecting the panretinal function of eyes without causing wounds in the clinic of ophthalmology.

A system and method for assessing the functionality of a visual system of the eye using a digital micro-mirror device (DMD) to generate a coded pattern which is illuminated by a light source. Optics project an image of the coded pattern onto the retina of the eye. Sensors detect electrical signals based on the response of the visual system to the image. One or more processors control the DMD and correlate the electrical response from the sensor with the coded DMD pattern to assess the functionality of the visual system.

A process for treating an eye to stop or delay the onset or symptoms of retinal diseases includes determining that the eye has a risk for a retinal disease before detectable retinal imaging abnormalities. A laser light beam is generated that provides preventative and protective treatment of the retinal tissue of the eye. At least a portion of the retinal tissue is exposed to the laser light beam without damaging the tissue. The retina may be retreated according to a set schedule or periodically according to the determination that the retina of the patient is to be retreated by monitored visual and / or retinal function or condition.

The invention relates to a research method for the relation between a laser photocoagulation range and a diabetic retinopathy prognosis, the purpose of which is to provide an important control strategy for the timing and method of treating the diabetic retinopathy with laser by comparatively analyzing the relation between the laser photocoagulation range and the diabetic retinopathy prognosis. By comparing different laser modes in three months of laser treatment, the research method discovers that the visual field defect of a diseased eye is obviously caused by panretinal laser photocoagulation while the retinal function outside the macular region is protected by local retinal laser photocoagulation and quadrant laser photocoagulation. The research proves that the quadrant retinal laser photocoagulation carried out on the diseased region of the retina can remarkably improve the anoxic state of the retina, prevent the growth of new blood vessels on the retina and protect the visual function of the macular region.

A process for treating an eye to stop or delay the onset or symptoms of retinal diseases includes determining that the eye has a risk for a retinal disease before detectable retinal imaging abnormalities. A laser light beam is generated that provides preventative and protective treatment of the retinal tissue of the eye. At least a portion of the retinal tissue is exposed to the laser light beam without damaging the tissue. The retina may be retreated according to a set schedule or periodically according to the determination that the retina of the patient is to be retreated by monitored visual and / or retinal function or condition.

The invention provides a system for imaging reflectance changes, intrinsic or extrinsic fluorescence changes of a retina (6) due to retinal function, including an imaging illuminator (14) for illumination of the retina (6); a retina-stimulating illuminator (2) for inducing a functional response; an imaging device (20) receiving light from the retina (6) via retinal imaging optics (12); image acquisition means (26) for digitizing and storing images received from the imaging device (20), and a computer (28) for controlling the operation of the system and for processing the stored images to reveal a differential functional signal corresponding to the retina's function.

The invention relates to the technical field of biomedical gene treatment, and discloses a nucleotide sequence for coding human receptor tyrosine kinase Mer and application thereof. The nucleotide sequence disclosed by the invention and the nucleotide sequence shown in SEQ ID NO: 3 have more than or equal to 95% identity. The application proves that by using an AAV-MERTK drug for treatment, the retinal pathology symptoms of rats with retinitis pigmentosa caused by MERTK mutation can be remarkably improved, and retinal function recovery can be remarkably improved. The AAV-MERTK drug is injectedinto a vitreous cavity, MERTK can be efficiently expressed in a retinal pigment epithelium layer, and the thickness of a retinal outer nuclear layer is increased. Meanwhile, a retinal potential diagram shows that compared with a control group, the rats in an AAV-MERTK drug treatment group have strong response to stimulation. Therefore, the AAV-MERTK drug has the effect of preventing or treating the retinitis pigmentosa.

The invention relates to the field of LED diabetes retinopathy treatment, particularly relates to a pair of LED treatment glasses. The invention is a pair of glasses in which the biology adjusting effect of LED lights is utilized to perform treatment effects. The glasses comprise a frame, a support, a sheet shape LED array, a minisize cell and a switch button. The inner side of the frame and the support is provided with a groove, the LED and the minisize cell are provided in the groove and the switch button controls the LED to emit lights or not. The activity of the retina cytochrome oxidase is improved through the LED treatment, which can effectively neutralize the influence from diabetes on retina oxidation metabolism. The LED treatment glasses help improve the function of the retina and are used for an improving treatment towards diabetes retinopathy patients.

A method for optical imaging of retinal function comprises an illuminating observing step (S1) of illuminating the retinal region (2) of the rear surface of an eyeball (1) including the macular area and the optic disk with an invisible light (3) and observing the retinal region (2), a stimulating step (S3) of illuminating the retinal region (2) with a visible flash light (4) to stimulate a retinal function including an optic disk's function, an imaging step (S2) of capturing images (A, B) before and after the stimulation of the retinal region (2) illuminated with the invisible light, and a calculating step (S4) of detecting the change of the retinal function of the retinal region from the images (A, B) before and after the stimulation. In the calculating step, the images (A, B) before and after the stimulation are registered in advance, and the change of the retinal function of the retinal region is displayed with an image from the registered images.

The invention relates to a composition for protecting eyesight. The composition can be used for protecting eyesight and adjuvant therapy of fundus diseases. The composition is composed of chromium, selenium, docosahexaenoic acid, zinc, xanthophyll and carotene. The composition comprises the following components by mass, 25*10 <-3>-35*10 <-3 > parts of chromium, 40*10<-3 >-60*10 <-3> parts of selenium, 250-350 parts of docosahexaenoic acid (DHA), 20-50 parts of zinc, 8-20 parts of xanthophyll and 3-5 parts of carotene. The composition can be applied to preparation of a medicine and a health care product for preventing and treating myopia, crystalline lens and retinopathy, improving eyesight, relieving asthenopia or tonifying and strengthening brain, which has the function of protecting eyesight by protecting visual cells, can prevent asthenopia and myopia and treat crystalline lens and retinopathy, has the effects of tonifying and strengthening brain, and is a health care product for pregnant women. The product is of great significance to eye and brain health care and maintenance, stabilization and recovery of lens and retina functions.