The invention relates to the technical field of computers, and provides a configuration item monitoring method and device, computer equipment and a storage medium. The method comprises the following steps: responding to a configuration item monitoring tool starting operation, starting a preset system new version release signal monitoring thread; when a new version release signal of the system is monitored; and obtaining a target configuration file of a to-be-published version of each subsystem, searching a reference configuration file corresponding to the target configuration file, identifyinga difference item in the target configuration file and the corresponding reference configuration file to obtain a difference item identification result, and collecting the difference item identification result in each subsystem to obtain a configuration item monitoring result of the to-be-published version of the system. According to the method, the configuration data can be conveniently adjustedsubsequently before the new version is issued, so that the online problem of the new version caused by misoperation of manual configuration modification is reduced, the accuracy of the configurationdata of the points which cannot be covered in the test regression stage after the system version is updated is effectively compensated, and the stability of the system in the running process is favorably improved on the whole.