A decoding method for optical storage device, which decodes channel bits upon a disc by partial response maximum likelihood (PRML) detection, is proposed. Unlike the conventional skills, the present method does not decode the detected RF signals directly, but adjusts values of parts of detected RF signals to their original ideal values before channel decoding instead, thereby reducing the decoding error rate of channel bits. The decoding method includes the step of: retrieving a first sequence of RF signals; identifying if the first sequence of RF signals contains a signal combination which satisfies a particular condition; adjusting a plurality of RF signals in the first sequence of RF signals to some pre-determined RF signals' value and then forming a second sequence of RF signals; and decoding the second sequence of RF signals. In a preferred embodiment of the invention, the method is applied to an optical storage system of PR (1,2,2,2,1) channel.