The invention relates to a temperature-sensitive in-situ
gel preparation composition for intra-articular injection and a preparation method thereof, and belongs to the field of
medicine preparations. The preparation method comprises the following steps: preparing
diclofenac sodium-carrying
sodium alginate microspheres by combining a
microsphere technology with a temperature-sensitive gel technology, and then carrying the
medicine-carrying microspheres in a
chitosan / beta-
sodium glycerophosphate temperature-sensitive in-situ gel
system to obtain a
diclofenac sodium in-situ
gel preparation composition. The composition is in a
liquid state at a
room temperature, capable of being converted to a semi-
solid gel at a body temperature and forming a
medicine storeroom at a medication part after being partially injected to enter an
articular cavity, and beneficial to slowly releasing the medicine, prolonging the time of staying at the injection part, of the medicine, and enhancing the
efficacy. The composition disclosed by the invention can be used for treating
arthritis diseases of
rheumatism,
rheumatoid arthritis,
osteoarthritis,
synovitis and the like, as well as applicable to both
diclofenac sodium and other
arthritis treatment medicines of non-steroidal anti-inflammatory medicines,
steroid hormone medicines, biological preparations and the like.