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71 results about "Haemophilia A" patented technology

Haemophilia A (or hemophilia A) is a genetic deficiency in clotting factor VIII, which causes increased bleeding and usually affects males. In the majority of cases it is inherited as an X-linked recessive trait, though there are cases which arise from spontaneous mutations.

Method of providing hemostasis in Anti-coagulated blood

In a method of clotting blood in which the blood exhibits a reduced tendency to clot and may be from a person undergoing an anticoagulant therapy or having type A or B hemophilia or von Willebrand disease, a therapeutically effective amount of a composition comprising clay as the active ingredient is administered to a wound from which the blood emanates. Upon contacting the blood, this clay, which may be kaolin, bentonite, or any type of layered clay, causes the blood to clot. In a method of arresting blood flowing from a wound, a therapeutically effective amount of a composition comprising clay as the active ingredient is administered to the bleeding wound. In this method, the blood has a reduced tendency to clot and may be from a person undergoing an anticoagulant therapy or having at least one of hemophilia A or B or von Willebrand disease.
Owner:TELEFLEX LIFE SCI LTD

Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer

ActiveUS6887852B1Same pharmaceutical efficacyAvoid virus infectionFactor VIIPowder deliveryMedicineArginine
Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.
Owner:KOREA GREEN CROSS CORP

Therapeutic method for blood coagulation disorder

The present invention provides agents for treating blood coagulation abnormalities, which contain as an active ingredient a lentiviral vector carrying a blood coagulation factor gene operably linked to a promoter which induces platelet-specific expression. Agents for treating hemophilia A or hemophilia B are provided by application of the gene encoding Factor VIII or Factor IX. Blood coagulation abnormalities can be treated by gene therapy by infecting hematopoietic stem cells or such with the therapeutic agents of the present invention.
Owner:DNAVEC CORP

Factor viii sequences

ActiveUS20150158930A1Many symptomIncrease of functional factor VIIIFactor VIIBacteriaGene deliveryNucleotide
There is provided a nucleic acid molecule comprising a nucleotide sequence encoding for a functional factor VIII protein, wherein the portion of the nucleotide sequence encoding for the B domain of the factor VIII protein is between 90 and 111 nucleotides in length and encodes for an amino acid sequence comprising a sequence having at least 85% identity to SEQ ID NO: 4 and which comprises six asparagine residues. Also provided is a functional factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating haemophilia, e.g. haemophilia A, and a method for the preparation of a parvoviral gene delivery vector.
Owner:UCL BUSINESS PLC

Recombinant factor viii having enhanced stability following mutation at the a1-c2 domain interface

InactiveUS20120065136A1Enhance inter-domain binding affinityIncreased stability parameterFactor VIIFungiFactor iiHaemophilia A
The invention relates to a recombinant factor VIII that includes one or more mutations at an interface of A1 and C2 domains of recombinant factor VIII. The one or more mutations include substitution of one or more amino acid residues with either a cysteine or an amino acid residue having a higher hydrophobicity. This results in enhanced stability of factor VIII. Methods for making the recombinant factor VIII, pharmaceutical compositions containing the recombinant factor VIII, and use of the recombinant factor VIII for treating hemophilia A are also disclosed.
Owner:UNIVERSITY OF ROCHESTER

Recombinant factor viii having reduced inactivation by activated protein c

The present invention relates to a recombinant factor VIII that is characterized by one or more mutations within a region surrounding an activated protein C cleavage site, which one or more mutations result in a reduced rate of inactivation by activated protein C. Isolated nucleic acid molecules, recombinant expression vectors, and host cells suitable for expression of the recombinant factor VIII are also disclosed. The recombinant factor VIII can be used for the treatment of clotting disorders, such as hemophilia A.
Owner:UNIVERSITY OF ROCHESTER

Methods and Compositions for Treating Bleeding Disorders

InactiveUS20160060324A1Induce immune toleranceFactor VIIPeptide/protein ingredientsImmune toleranceB cell
The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity.
Owner:THE SCRIPPS RES INST

Anti-idiotypic antibody neutralizing the inhibitor activity of a factor viii inhibitor antibody

InactiveUS20070065425A1Reduce antibody immunogenicityImprove efficiencyAnimal cellsSugar derivativesFactor VIII inhibitorAnti-idiotypic antibodies
The present invention is related to a monoclonal anti-idiotypic antibody directed against a Factor VIII inhibitor antibody binding to the domain A2 of Factor VIII, and to a cell line producing this monoclonal anti-idiotypic antibody, to the use of this monoclonal anti-idiotypic antibody as drug, and more particularly, to its use for the manufacturing of a drug to be used for the treatment of haemophilia A.
Owner:LFB BIOTECH

Severe hemophilia A disease-causing gene mutation detection kit

The invention belongs to the field of biotechnology and biomedicine, and particularly relates to a kit for detecting inversion mutation of intron 22 and intron 1 of a severe hemophilia A disease-causing gene. The severe hemophilia A disease-causing gene mutation detection kit comprises Inv22 PCR (polymerase chain reaction) liquid and Inv1 PCR liquid, the Inv22 PCR liquid comprises three primers for detecting gene inversion of the intron 22 of the severe hemophilia A disease-causing gene, and the Inv1 PCR liquid comprises three primers for detecting gene inversion of the intron 1 of the severe hemophilia A disease-causing gene. Long fragment amplification stability of Inv22, detection sensitivity, PCR product quantity and electrophoresis detection abundance are improved, the problems of short preservation time, poor temperature tolerance and the like of reagents are solved by further adding Taq DNA (deoxyribonucleic acid) polymerase inhibitors, and stability of clinical application of the kit is improved.
Owner:亚能生物技术(深圳)有限公司

Blood Coagulation Factor VIII Activation-Enhancing Antibodies

For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.
Owner:CHUGAI PHARMA CO LTD +1

Correction of factor VIII genetic defects using spliceosome mediated RNA trans splicing

The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA). In particular, the PTMs of the present invention are genetically engineered to interact with factor VIII (FVIII) target pre-mRNA so as to result in correction of clotting FVIII genetic defects responsible for hemophilia A. The compositions of the invention further include recombinant vector systems capable of expressing the PTMs of the invention and cells expressing said PTMs. The methods of the invention encompass contacting the PTMs of the invention with a FVIII target pre-mRNA under conditions in which a portion of the PTM is trans-spliced to a portion of the target pre-mRNA to form a RNA molecule wherein the genetic defect in the FVIII gene has been corrected. The methods and compositions of the present invention can be used in gene therapy for correction of FVIII disorders such as hemophilia A.
Owner:VIRXSYS

Targeting tissue factor to activated platelets

The current invention relates to procoagulant fusion proteins, polynucleotides that encode said fusion proteins and cells that expresses said fusion proteins. Furthermore, the current invention relates to fusion proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with fusions proteins of the current invention.
Owner:NOVO NORDISK AS

Demannosylated recombinant factor viii [[vii]] for the treatment of patients with haemophilia a

There is provided in accordance with the practice of this invention a demannosylated Factor VIII, the immunogenicity of which is substantially decreased or abolished in Human. The modified factor VIII is disclosed together with the modified amino acid sequence, changed by at least one substitution. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory anti-FVIII antibodies.
Owner:LFB BIOTECH +1

Cytotoxic Antibodies Directed Against Antibodies Inhibiting Factor VIII

The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable region of each of the light chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 1, and the variable region of each of the heavy chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 2, the constant regions of the light chains and the heavy chains being constant regions from a non-murine species. The invention also relates to the use of said antibody for activating the FcγRIII receptors of cytotoxic immune cells, and to the production of a medicament especially for the treatment of haemophilia A.
Owner:LFB BIOTECH
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