30 results about "Blood Vessel Grafting" patented technology

Disclosed is a conduit that provides a bypass around an occlusion or stenosis in a coronary artery. The conduit is a tube adapted to be positioned in the heart wall to provide a passage for blood to flow between a heart chamber and a coronary artery, at a site distal to the occlusion or stenosis. The conduit has a section of blood vessel attached to its interior lumen which preferably includes at least one naturally occurring one-way valve positioned therein. The valve prevents the backflow of blood from the coronary artery into the heart chamber.

Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.

A synthetic blood vessel graft (e.g., for use with a prosthetic heart valve) includes a mounting cuff adjacent at least one end for facilitating attachment of the graft to another structure (e.g., a sewing cuff of a heart valve). The mounting cuff may be sized and shaped to provide good conformance to the target structure to which it may be attached (e.g., the heart valve sewing cuff). The graft is preferably preclotted. Especially for use with a tissue valve (which must be supplied in a packaging solution that would react with a preclotting agent), the graft is preferably supplied separately from the valve.

A graft for replacement of a section of an artery and methods of making the graft. The graft comprises a flexible, resilient, generally tubular external support and a blood vessel segment, e.g., a vein segment, carried within and having an ablumenal surface in contact with and supported by the tubular support, the graft being capable of resilient radial expansion in a manner mimicking the radial compliance properties of an artery.

The present invention encompasses an adipose-derived adult stromal (ADAS) cell exhibiting at least one characteristic of a pre-endothelial cell and / or an endothelial cell. The present invention also encompasses compositions and methods for generating an adipose-derived adult stromal to exhibit at least one characteristic of a pre-endothelial cell and / or an endothelial cell. Methods for using the cells in vascular transplantation, tissue engineering, regulation of angiogenesis, vasculogenesis, and the treatment of numerous disorders including heart disease are also included.

The invention relates to an artificial blood vessel and a preparation method thereof and belongs to the technical field of organ preparing and biological materials. The artificial blood vessel comprises an outer cortex layer, a fibroblast layer, a smooth muscle cell layer, an endothelial cell layer and an inner cavity. The orderly distribution of the endothelial cell layer, the smooth muscle cell layer, the fibroblast layer and the outer cortex layer in the three-dimensional space is achieved through the comprehensive technology of plasma spraying, electric spraying, electrospinning, reverse molding and 3D printing, the anti-coagulation performance of the artificial blood vessel is enhanced through anti-coagulation factors, step-by-step induced differentiation of stem cells in the artificial blood vessel is achieved through a growth factor controlled-release method, the artificial blood vessel is cultured through a pulsation reactor and made to simulate natural animal blood vessels on the structure and the function, and a corresponding substitute is provided for blood vessel transplanting and repairing. The artificial blood vessel is also applicable to other tubular tissue and organs such as the oesophagus, the trachea, the ovarian duct, the bile duct, the urethra and the bladder.

The present technology is related to the field of sterilization and decellularization of allografts or xenografts, specifically to processes that achieve effective removal of the cells contained within a vascular tissue matrix and an effective reduction in potential harmful organisms to create grafts suitable for human implantation. In some embodiments, vascular grafts, vascular tissue and / or blood vessels are contacted with cleaning solution under conditions suitable conditions to reduce immune reaction in patients. More specifically, the present technology is directed to sterilization and decellularization of vascular grafts.

A vascular graft sizer for gauging the size of a distorted blood vessel includes a sizing member. The sizing member has a shape substantially similar to a shape of a distorted blood vessel, and corresponds to a vascular graft that has a shape substantially similar to a non-distorted blood vessel.

The invention relates to a bioengineering technology, in particular to a small-caliber biotic artificial blood vessel with anti-thrombus formation and anti-intimal hyperplasia functions. Firstly, the key technology of accellular materials and natural polymer composition is used, and through multiple modes, neurotrophic factors are effectively coupled as functional modules to perform modification on blood vessel supports. Furthermore, through the strategy of constructing in body, the small-caliber engineering blood vessel modified by the neurotrophic factors is transplanted in body, the scour and the pressure of hemodynamics are overcome in body, endothelial progenitor cells in circulation are captured initiatively, the endothelial progenitor cells are further induced to differentiate into endothelial cells in situ, and the progress and the quality of endothelialization of blood vessel graft are speeded. Meanwhile, the generation of blood capillaries is promoted and nurtured, the blood vessel implants are promoted to remodel in body, therefore, the effects of anti-thrombus formation and anti-intimal hyperplasia can be effectively achieved, and the patency rate after the small-caliber biotic artificial blood vessel is transplanted is increased. Active small-caliber tissue engineering blood vessels used for coronary arterie bypass grafting, hematodialysis and cerebrovascular replacement in clinic are built.

A method for implanting the endothelial cells on the inner surface of artificial blood vessel features that a biomechanical method is used, that is, an external pulsive fluid shearing force increased step by step acts on the planted endothelial cells to make them be attached well on the inner surface of artificial blood vessel in advance.

The present invention relates to me methods for minimizing spasticity in blood vessels during transplantation and more particularly for minimizing spasticity in arterial transplants, for both ex-vivo and in-vivo procedures. The invention also relates to formulations, which can be used in these methods.

The artificial blood vessel comprises a cortex layer, a fibroblast layer, a smooth muscle cell layer, an endothelial cell layer and an inner cavity. According to the artificial blood vessel, the endothelial layer, the smooth muscle cell layer, the fibroblast layer and the cortex layer are orderly arranged in a three-dimensional space by utilizing integrated technologies of plasma spraying, electrospraying, electrospining, intra-mold pouring and 3D printing; anticoagulant activity of the artificial blood vessel is enhanced by adopting an anticoagulation factor; step-by-step induced differentiation of stem cells in the artificial blood vessel is realized by adopting a growth factor controlled release method; and the artificial blood vessel is cultured by a pulsatile reactor, so that the artificial blood vessel structurally and functionally simulates natural animal blood vessels and provides a corresponding substitute for vascular transplantation and repair.

A method and device are disclosed directed at harvesting of vessels, such as arteries and veins, especially as required in vessel grafting procedures. The device and method discloses a cannula-like device that provides, identification, capture, manipulation, hemostasis and cleavage of branch vessels from the harvested vessel without need for further devices. In certain preferred embodiments of the disclosed method and device, the disclosed harvesting device achieves branch vessel cleavage and hemostasis without the use of heat producing means such as cautery. In addition, certain embodiments utilize a clip / coil magazine technology so as to enable severance and hemostasis of multiple branch vessels without need for removal of the device from the surgical site. Further embodiments disclose the incorporation and use of irrigants containing CO2, as well as other agents capable of stimulate release of nitric oxide from vascular endothelium are applied to subject vessels so as to enhance the viability of vessels to be harvested as graft material.

External support implant for unbound covering of a blood vessel graft in a peripheral vascular bypass system. The implant includes: elongate body having a longitudinal axis, and interior collapsible upon exterior of the blood vessel graft. Elongate body includes tubular fabric having intertwined coiled compression springs configured for elastically resisting longitudinal compression of the elongate body from a relaxed length, when compression springs are slightly stressed, and for elastically increasing diameter of the elongate body when compression springs are subjected to the longitudinal compression.

The present invention encompasses an adipose-derived adult stromal (ADAS) cell exhibiting at least one characteristic of a pre-endothelial cell and / or an endothelial cell. The present invention also encompasses compositions and methods for generating an adipose-derived adult stromal to exhibit at least one characteristic of a pre-endothelial cell and / or an endothelial cell. Methods for using the cells in vascular transplantation, tissue engineering, regulation of angiogenesis, vasculogenesis, and the treatment of numerous disorders including heart disease are also included.

A method and device are disclosed directed at harvesting of vessels, such as arteries and veins, especially as required in vessel grafting procedures. The device and method discloses a cannula-like device that provides, identification, capture, manipulation, hemostasis and cleavage of branch vessels from the harvested vessel without need for further devices. In certain preferred embodiments of the disclosed method and device, the disclosed harvesting device achieves branch vessel cleavage and hemostasis without the use of heat producing means such as cautery. In addition, certain embodiments utilize a clip / coil magazine technology so as to enable severance and hemostasis of multiple branch vessels without need for removal of the device from the surgical site. Further embodiments disclose the incorporation and use of irrigants containing CO2, as well as other agents capable of stimulate release of nitric oxide from vascular endothelium are applied to subject vessels so as to enhance the viability of vessels to be harvested as graft material.

An intelligent tissue engineered blood vessel. Cardiovascular disease has become a major disease that endangers human health. The most commonly used treatment method is blood vessel transplantation, and a large number of artificial blood vessel substitutes are needed clinically. By intercepting the bilateral carotid arteries of sheep, the method of decellularization and antigen removal by TritonX-100+DNA / RNase digestion was adopted; the slow-release microspheres loaded with VEGF were prepared by emulsification and volatilization method using high molecular substances (PLGA), polyvinyl alcohol and VEGF. ; The decellularized sheep carotid artery stent and slow-release microspheres were tightly combined by freeze-drying to produce tissue-engineered blood vessels loaded with VEGF slow-release microspheres that can directionally induce endothelial cell adsorption, differentiation and proliferation, which is expected to solve the clinical problems encountered in vascular transplantation. Difficulties faced: the limited source of vascular grafts, the rejection of simple heterogeneous vascular grafts, and the poor long-term patency of existing tissue engineered vascular grafts, etc., as a vascular graft substitute for the treatment of human cardiovascular diseases.

The invention provides a blood vessel graft for clinical vascular transplantation and a preparation method thereof, belongs to the field of medical biomaterials, and mainly solves the problems of limited autologous blood vessel sampling, complicated operation, high risk of allogeneic blood vessels and poor compliance force or calcification of macromolecular material implantation in vivo currentlyin clinic. According to the characteristics of different structures and different tissues and cells of natural blood vessels, three layers of receptor own tissue cells are planted, the bearing mechanical parameters and blood flow conditions of blood vessels in vivo are finally simulated, the product is prepared, and the purpose of autologous blood vessel repair is achieved. The material prepared by the method is prepared by culturing a collagen and receptor own tissue cells in a vascular bioreactor, is close to autologous blood vessels, has good biocompatibility, has growth potential, is not easy to infect, has strong mechanical properties, can bear the transmural pressure and the compliance force of blood flow to blood vessel walls, has good anti-thrombosis and anti-platelet adhesion effects, and is beneficial for vascular repair in vascular transplantation.

Procedure for fitting of vascular implant with an active principle comprises immersing the implant body in an alcoholic solution or an alcoholic solution with a light volatile solvent e.g. chloroform, and a member of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate or vancomycin myristate, or sprinkling the alcoholic solution on the implant body; and vaporizing the solvent, where the active principle is antithrombosis. An independent claim is included for a coated vascular implant, produced by the above procedure, a further medicament material is dispersed or suspended in the coating.

One or more substances of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, vancomycin laurate, and vancomycin myristate are suitable for providing vascular grafts with an antithrombogenically active principle. The appropriate method for providing vascular grafts with an antithrombogenically active principle particularly comprises the following steps of A immersing the graft body in an alcoholic solution or an alcoholic solution with a readily volatile solvent, such as chloroform, wherein the alcoholic solution is of a member of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, and vancomycin myristate, or of spraying said solution on said graft body, and of B vaporizing said alcoholic solvent.

The invention discloses a 3D-printing blood vessel transplantation material as well as a composition and preparation method thereof. The composition of the 3D-printing blood vessel transplantation material comprises a main frame set and a connector set which are stored independently, wherein the main frame set comprises a first high-molecular-weight polymer A, a first low-molecular-weight polymer B and an optional first drug, and the connector set comprises a second high-molecular-weight polymer C, a second low-molecular-weight polymer D and an optional second drug; wherein the molecular weight of the first high-molecular-weight polymer A and the molecular weight of the second high-molecular-weight polymer C are respectively and independently 20kDa-100kDa; and the molecular weight of the first low-molecular-weight polymer B and the molecular weight of the second low-molecular-weight polymer D are respectively and independently 200Da-5,000Da. According to the 3D-printing blood vessel transplantation material disclosed by the invention, a biodegradable material is prepared into various forms of blood vessel grafts suitable for human body requirements by utilizing a 3D technology, particularly an artificial blood vessel graft as a small-diameter blood vessel.

The present invention relates to the use of a compound of formula (I), wherein R1 is pyridyl or thiazolyl, any of which may optionally be substituted with C1-8alkyl or C2-8alkenyl; and a) R2 is methoxy and n is zero or one; or b) R2 is chlorine and n is zero; and pharmaceutically acceptable salts thereof for the prevention of blood vessel graft failure in patients undergoing artery bypass graft surgery.