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Preparing blood vessel graft containing active components

An active ingredient, vascular transplantation technology, applied in anticoagulant treatment, packaging item types, special packaging items, etc., can solve the problems of sepsis, organ loss, patient death, etc.

Inactive Publication Date: 2011-11-09
HERAEUS MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It may result in loss of vascularized organs / sepsis, which may result in septic shock and death of the patient

Method used

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  • Preparing blood vessel graft containing active components
  • Preparing blood vessel graft containing active components

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Vascular prostheses made of expanded PTFE (6 mm in diameter) were dipped in a 5% by weight solution of gentamicin palmitate in methanol for 60 seconds at room temperature. Then, the vascular PTFE prosthesis was dried at room temperature until a constant mass was achieved. The applied gentamicin palmitate coating was measured gravimetrically. The results showed a loading of 0.95 mg gentamicin palmitate per cm of vascular PTFE prosthesis. Scanning electron micrographs of coated vascular PTFE prostheses are shown in figure 1 middle.

Embodiment 2

[0026] Vascular prostheses made of expanded PTFE (diameter 6 mm) were dipped in 5% by weight gentamicin palmitate in methanol (containing 1% by weight argatro plaque) for 60 seconds at room temperature. Then, the vascular PTFE prosthesis was dried at room temperature until a constant mass was achieved. The applied gentamicin palmitate coating was measured gravimetrically. The results showed a gentamicin palmitate loading of 0.97 mg per cm of vascular PTFE prosthesis.

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Abstract

One or more substances of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, vancomycin laurate, and vancomycin myristate are suitable for providing vascular grafts with an antithrombogenically active principle. The appropriate method for providing vascular grafts with an antithrombogenically active principle particularly comprises the following steps of A immersing the graft body in an alcoholic solution or an alcoholic solution with a readily volatile solvent, such as chloroform, wherein the alcoholic solution is of a member of the group consisting of gentamicin palmitate, gentamicin myristate, gentamicin laurate, tobramycin palmitate, tobramycin myristate, tobramycin laurate, amikacin palmitate, amikacin myristate, amikacin laurate, vancomycin palmitate, and vancomycin myristate, or of spraying said solution on said graft body, and of B vaporizing said alcoholic solvent.

Description

technical field [0001] The object of the present invention is the preparation of vascular grafts containing active ingredients. Background technique [0002] In vascular surgery, vascular prostheses are currently used on a large scale to treat vascular defects. Among them, porous PTFE (polytetrafluoroethylene) vascular prostheses and braided polyester prostheses (polyester fabrics) are used in particular. After implantation of a vascular prosthesis, a blood clot may form in the area of ​​the vascular prosthesis during the first few hours when blood flow resumes. This can weaken or block blood flow, and the resulting clots can harbor bacteria. In the modern era of antibiotics, the problem of infected vascular prostheses remains a dire side effect and a potentially fatal hazard for patients. It may lead to loss of vascularized organs / sepsis, the result of which may be septic shock, resulting in death of the patient. [0003] For the above reasons, it is desirable to provid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L33/04A61F2/06
CPCA61L2300/45A61L27/507A61L2300/258A61L2300/42A61L27/54A61L33/0041A61P31/04
Inventor K·-D·屈恩S·福格特M·施纳贝尔奥赫
Owner HERAEUS MEDICAL
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