46 results about "Airway smooth muscle" patented technology

Methods of increasing gas exchange performed by the lung by damaging lung cells, damaging tissue, causing trauma, and / or destroying airway smooth muscle tone with an apparatus inserted into an airway of the lung. The damaging of lung cells, damaging tissue, causing trauma, and destroying airway smooth muscle tone with the apparatus may be any one of or combinations of the following: heating the airway; cooling the airway; delivering a liquid to the airway; delivering a gas to the airway; puncturing the airway; tearing the airway; cutting the airway; applying ultrasound to the airway; and applying ionizing radiation to the airway.

The present invention relates to a medicine for treating airway hyperresponsiveness disease, 5-(3-phenylpropionylamino)-N-(4-ethoxycarbonylphenyl)-1H-3-indolecarboxamide. The drug is a CD38 enzyme inhibitor, which can treat airway hyperresponsiveness disease symptomatically by inhibiting the release of Ca2+ to dilate tracheal smooth muscle; we use ozone to create a mouse airway hyperresponsiveness model, and at the same time give the drug's emulsifier for intragastric treatment , it was found that the airway resistance of the mice treated with the drug was significantly reduced, the dynamic lung compliance was significantly increased, and the degree of lung lesions was reduced; The development value of land belongs to the field of medicine.

The invention provides an artemisia apiacea extract. The artemisia apiacea extract is prepared by the following steps: selecting dry artemisia apiacea as a raw material and grinding the artemisia apiacea into powder; heating the powder by using deionized water at 50-60 DEG C for 3h, vibrating once per 15min, filtering and collecting filtrate; repeatedly extracting filter residues once; merging the filtrate; evaporating to dryness by using a rotary evaporator and collecting residues; dissolving the residues into the deionized water, extracting the solution by using isopyknic petroleum ether for 2-4h, removing grease and other petroleum ether-soluble materials and collecting percolate; and extracting by using isopyknic chloroform, collecting an extract liquid, evaporating to dryness and preparing paste, namely the artemisia apiacea chloroform extract. An experiment shows that the extract is capable of relaxing airway smooth muscle and can be used for relieving airway obstruction of an asthma patient, so that the artemisia apiacea chloroform extract can be applied to preparation of medicines for treating bronchial asthma.

The invention provides a lotus plumule chloroform extract. The lotus plumule chloroform extract is prepared by adopting the following steps: selecting dry lotus plumule as a raw material, and grinding into powder; adopting methyl alcohol or ethyl alcohol to carry out heating reflux extraction two to four times, and collecting an extract; carrying out centrifugal treatment on the extract, collecting supernatant, then evaporating the supernatant to dryness by using a rotary evaporator, and collecting residues; dissolving the residues to a hydrochloric acid solution, extracting two to four times by using petroleum ether, removing oils and fats, and collecting a filtrate; adjusting the pH value of the filtrate to be 9-11, then extracting by using chloroform, collecting an extract liquor and evaporating to obtain an extract, namely the lotus plumule chloroform extract. Experiments show that the extract can relax airway smooth muscle, and can be used for relieving the airway obstruction of an asthma patient, so that the lotus plumule chloroform extract can be applied to the preparation of medicine for treating bronchial asthma.

The invention discloses a pharmaceutical composition capable of relaxing tracheal smooth muscles, and relates to the technical field of medicine. The pharmaceutical composition contains the active ingredients including a jasmine flower aqueous solution extract and clarithromycin, wherein the weight ratio of clarithromycin to the jasmine flower aqueous solution is (2-20):1. The pharmaceutical composition is applied to treatment on an asthma disease in an aerosol form, the treatment effect is obvious by jointly applying the jasmine flower aqueous solution extract and clarithromycin, few toxic and side effects are generated, the compliance of a patient is improved, and the life quality of the patient is significantly improved.

The invention relates to the technical field of medicine, in particular to an application of dictamnine to preparation of a medicine for relaxing precontracted tracheal smooth muscles. The action mechanism of the dictamnine in the aspect of relaxing the pre-stimulated airway smooth muscle is found, particularly, the dictamnine has a relaxing effect on contraction of the airway smooth muscle induced by high potassium and acetylcholine, and a basis is provided for developing the dictamnine for relaxing the airway smooth muscle to prepare the medicine for treating asthma.

The present invention relates to a composition for preventing, alleviating or treating respiratory diseases, containing a Siraitia grosvenorii residual extract as an active ingredient. In an ovalbumin(OVA) induced asthma animal model, a Siraitia grosvenorii residual extract of the present invention has effects of reducing airway hypersensitivity, inhibiting inflammatory cells in bronchoalveolar lavage fluid and reducing Th2 cytokines (IL-4, IL-5 and IL-13) in bronchoalveolar lavage fluid, reducing inflammation and tissue damage in lung tissue, inhibiting airway smooth muscle contraction and airway inflammation, inhibiting the expression of IL-13, TARC, TNF-a, IL-17 and mucus gene MUC5AC in lung tissue, and reducing, in alveolar cells, ROS having increased because of fine dust.

The invention relates to the field of a protein drug, and particularly discloses novel use of S100 calcium binding protein A11 for preparation of a drug for relaxing airway smooth muscle, and a drug preparation containing the protein. The invention discloses a novel function of the S100 calcium binding protein A11 for relaxing the airway smooth muscle. The airway smooth muscle can be obviously relaxed by the S100A11; the airway resistance of an asthma model rat is reduced, so as to play a role of treatment of asthma. The S100 calcium binding protein A11 can be applied to treatment of an asthma disease and preparation of a drug for treating asthma, and is applied to the quality of the asthma disease in a form of an injection or spray. Therefore, the S100 calcium binding protein A11 has the advantages of being safe, effective and stable to use and the like.