Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma

A technology of tracheal smooth muscle and diacerein, applied in the field of medicine

Inactive Publication Date: 2020-02-14
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Diacerein relaxes airway smooth muscle in the treatment of asthma, but there is no relevant report at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma
  • Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma
  • Application of diacerein in relaxation of preshrunk tracheal smooth muscles and treatment of asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] 1. Experimental animals:

[0045] Healthy sexually mature male BALB / c mice, SPF grade, with an average age of 6-8 weeks were purchased from Hubei Provincial Center for Disease Control and Prevention (Wuhan, China). Optimum environment for raising mice: 12 hours (8:00-20:00) light-dark cycle, room temperature maintained at 20-25° C., and humidity maintained at 50-60%.

[0046] 2. Experimental consumables and equipment:

[0047]Microscope (IX71) (Olympus Corporation); dissecting mirror (XTL-2300) (Shanghai Precision Instrument Company); stereo microscope (SZM) (Wuhan Aispe Scientific Instrument Co., Ltd.); ultrapure water system (Aike Pu Company); biological function experiment system (BL-420S) (Chengdu Taimeng Technology Co., Ltd.); HV-4 type constant temperature perfusion system for isolated tissues and organs (Chengdu Taimeng Technology Co., Ltd.); tension transducer (JH-2 Type) (China Beijing · Institute of Aerospace Medical Engineering); Circulating water vacuum pu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of diacerein in relaxation of preshrunk tracheal smooth muscles and preparation of a medicine for treating asthma, which belong to the field of medicines. The in-vitro tracheal ring muscle tension of an experimental mouse is detected, the diacerein has the effect of efficiently relaxing tracheal smooth muscles, especially can relax high-potassium induced airway smooth muscle preconstriction and acetylcholine induced airway smooth muscle preconstriction, and is expected to be applied to relieving the symptom of airway obstruction during attack of asthma patients.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of diacerein (Diacerein) in relaxing and pre-contracting tracheal smooth muscle and treating asthma, which can be used for the development of new drugs for preventing or treating asthma. Background technique [0002] Asthma is a serious chronic respiratory disease and an allergic disease with abnormal immune function, which is a worldwide problem. However, the disease not only has a high incidence rate, but also has a long course of disease and is prone to repeated attacks, which is also a serious public health problem. In recent years, with the in-depth research on genetics, immunology, cytology, biology and molecular biology, the research on the pathogenesis of bronchial asthma has also made unprecedented progress, marking a new step in the prevention and treatment of asthma. new steps. However, the pathogenesis of asthma is extremely complicated, and some m...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/222A61P11/06
CPCA61K31/222A61P11/06
Inventor 沈金花时顺波
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com