Preparation process of macroporous sodium polyacrylate embolization microspheres

Abstract

The invention discloses a preparation process of macroporous sodium polyacrylate embolism microspheres, and relates to the technical field of medical instruments, the macroporous sodium polyacrylate embolism microspheres are subjected to suspension polymerization by taking a dispersing agent and water as continuous phases and taking a monomer acrylate compound, a cross-linking agent polyolefine compound, a pore-foaming agent and an initiator as dispersion phases, and the macroporous sodium polyacrylate embolism microspheres are obtained. And carrying out a hydrolysis process to obtain the macroporous sodium polyacrylate embolization microspheres. The prepared macroporous sodium polyacrylate embolization microspheres have high elasticity and large drug loading capacity. According to the invention, a suspension polymerization process is adopted for the first time, and the obtained macroporous microspheres have better intragranular microporous channels, are convenient for intragranular diffusion of molecules, have better ion exchange kinetics performance, are more suitable for medium-molecular chemotherapeutic drugs to quickly enter the microporous channels and exchange of functional groups, and greatly improve the drug loading capacity; the macroporous microspheres are more uniform in polymerization, and have higher strength and better elasticity compared with the macroporous microspheres.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a preparation process of macroporous sodium polyacrylate embolization microspheres. Background technique [0002] Interventional therapy is a new discipline developed in recent years, and it has been listed as the three pillar clinical disciplines together with traditional internal medicine and surgery. Embolization therapy is an important part of interventional therapy. Embolization therapy has been used in arteriovenous malformations, tumors with enlarged blood vessels, uterine fibroids, uterine fibroids, and blood supply by blocking blood vessels, malformed blood vessels, or bleeding blood vessels. Abundant tumors and other aspects have achieved good curative effect, and has broad application prospects. [0003] The key to transcatheter embolization (TACA for short) is to choose the appropriate embolic agent. At present, the most widely used clinically is the microsp...

AI Technical Summary

Problems solved by technology

Some of these microspheres are irregular in shape and non-uniform in size, which can lead to side effects such as drift, blockage of blood vessels, and misembolization during interventional procedures, and cause damage to normal tissues.

Although some microspheres have a smooth surface, regular shape, and relatively uniform size, the microspheres have poor elasticity and stretchability, and poor conductivity. incomplete embolization

There are also microspheres that cannot bind chemotherapy drugs or have low drug loading, or the loaded drugs cannot be released slowly in blood vessels.

[0004] The currently published invention patents and commercially available embolic microsphere products are mainly gel-type products. The gel-type embolic microspheres have the problem of small micropores, which leads to the fact that when the drug is loaded, the chemotherapeutic drugs for middle molecules are mostly in the microspheres. The drug is loaded on the surface of spherical particles, and the drug loading is low

Moreover, when the gel-type microspheres are polymerized, heat will be released at the moment of chain growth, which will lead to a sharp rise in temperature and sudden polymerization, so there will be uneven cross-linking