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A kind of degradable zinc-lithium alloy surface coating and preparation method and use thereof

A surface coating and alloy technology, which is applied in the field of degradable zinc-lithium alloy surface coating and its preparation, can solve the problems of cytotoxicity and other problems, and achieve the effects of promoting angiogenesis, promoting osteogenic differentiation, and improving bone regeneration

Active Publication Date: 2022-07-29
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention can solve the problem of cytotoxicity caused by zinc-lithium alloy releasing a large amount of zinc ions in the early stage of degradation, and can improve the effect of promoting osteogenesis and promoting angiogenesis on the surface of the zinc-lithium alloy, and the preparation process of the coating is simple, convenient and effective, and can Suitable for degradable zinc-lithium alloy surfaces of different sizes and shapes

Method used

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  • A kind of degradable zinc-lithium alloy surface coating and preparation method and use thereof
  • A kind of degradable zinc-lithium alloy surface coating and preparation method and use thereof
  • A kind of degradable zinc-lithium alloy surface coating and preparation method and use thereof

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Effect test

Embodiment 1

[0025] A preparation method of a degradable zinc-lithium alloy surface coating, a composite material prepared by using the adhesion mechanism of dopamine and its derivatives, the base of which is a biodegradable and degradable zinc-lithium alloy, and the middle is a layer with light The thermal effect of photothermal coupling agent copper sulfide (CuS) nanoparticles, the surface is a layer of photocured stable coating photocurable polycaprolactone (EFL-PCLMA). Among them, the zinc substrate can degrade and release zinc ions to promote the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSCs). The temperature for osteogenic differentiation of mesenchymal stem cells is (40 ± 0.5) °C; the stable coating on the outer surface can effectively control the heating rate of the material. When the material is irradiated with near-infrared light, the material will melt during the heating process and gradually expose the material substrate, thereby regulating the ...

Embodiment 2

[0034] The steps of preparing the photothermal responsive coating containing copper sulfide nanoparticles on the surface of Zn-0.1Li alloy are as follows:

[0035] (1) The extruded Zn-0.1Li alloy bar with a diameter of 10 mm is selected, and it is cut into a circle with a thickness of 1.5 mm by mechanical processing technology. The metallographic sandpaper was polished step by step, then ultrasonically cleaned in acetone and anhydrous ethanol for 20 min, air-dried at room temperature, and stored in a vacuum drying oven;

[0036](2) Preparation of copper sulfide nanoparticles: 0.6 mmol copper chloride dihydrate (CuCl 2 ·2H 2 O) and 0.408 mmol sodium citrate (C 6 H 5 Na 3 O 7 ) into 180 mL of deionized water, followed by dropwise addition of 20 mL of sodium sulfide nonahydrate (Na 2 S·9H 2 O), stirred at room temperature for 5 min, and then heated the reaction mixture to 90 °C for 15 min to complete the preparation of copper sulfide nanoparticles.

[0037] (3) Preparatio...

Embodiment 3

[0042] SD rat model of ectopic osteogenesis in vivo

[0043] (1) In vitro cell experiments

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Abstract

A degradable zinc-lithium alloy surface coating, the base of which is a zinc-lithium alloy binary alloy or a ternary alloy, bonded by dopamine hydrochloride, a layer of copper sulfide nanoparticles with photothermal effect in the middle, and a surface of which is a layer of Heat-sensitive polymer material surface protection layer. The invention uses the insulating effect of the surface polymer material coating and changes the exposed area of ​​the zinc substrate and the concentration of released zinc ions through the melting of the coating at different temperatures, thereby solving the problem that the zinc-lithium alloy is degraded too quickly in the body in the early stage of implantation , The cytotoxicity problem caused by the local accumulation of excessive zinc ions; copper sulfide nanoparticles are used as photothermal coupling agents to achieve photothermal conversion under 808nm infrared light irradiation, so that the surface of the material can promote the osteogenic differentiation of human bone marrow mesenchymal stem cells. temperature, improve the effect of bone regeneration.

Description

technical field [0001] The invention relates to a surface modification technology of bone implant materials, in particular to a degradable zinc-lithium alloy surface coating and a preparation method and application thereof. Background technique [0002] Degradable zinc-lithium alloys are new medical metal materials with high application prospects. Degradable zinc-lithium alloys have many advantages as bone implant materials. First, the standard electrode potential of zinc (-0.76 V) is between magnesium (-2.37 V) and iron (-0.44 V), and the corrosion rate is closer to the requirements of bone implant use; second, the strength of zinc-lithium alloys It is higher than magnesium alloys; in addition, zinc is the second most abundant transition metal element in the human body and participates in many important physiological functions of the body, including nucleic acid metabolism, signal transduction and gene expression. [0003] In vitro studies have shown that the higher conce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/30A61L27/34A61L27/50A61L27/54C23C26/00
CPCA61L27/047A61L27/306A61L27/34A61L27/50A61L27/54C23C26/00A61L2430/02A61L2400/12A61L2300/102A61L2300/40A61L2300/606A61L2420/02A61L2420/08C08L67/04
Inventor 周永胜夏丹丹刘云松徐钰倩
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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