Preparation method of etimicin sulfate effervescent tablet

A technology for etimicin sulfate and effervescent tablets, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as substandard hardness of tablets, and achieve rapid absorption. , the convenience of taking, the effect of increasing medication compliance

Pending Publication Date: 2021-08-31
WUXI JIMIN KEXIN SHANHE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But the contriver ran into difficulty in the process of preparing etimicin sulfate effervescent tablet, because the characteristic of special powder crystallization of etimicin sulfate, when carrying out powder direct compression, tablet hardness often does not reach the standard, for this reason The inventor has improved the related process

Method used

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  • Preparation method of etimicin sulfate effervescent tablet
  • Preparation method of etimicin sulfate effervescent tablet
  • Preparation method of etimicin sulfate effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] An etimicin sulfate effervescent tablet, its main components include 10% etimicin sulfate, 5% tartaric acid, 5% sodium bicarbonate, 3.5% disodium glycyrrhizinate, 1.5% orange flavor, Talc 5%, the rest anhydrous lactose.

[0041] Preparation:

[0042] Step 1. Etimicin sulfate fine powder and 1 / 3 anhydrous lactose are mixed uniformly in equal increments;

[0043] Step 2. Mix tartaric acid, sodium bicarbonate, disodium glycyrrhizinate, orange essence, talcum powder and 2 / 3 anhydrous lactose in equal increments and pass through a 200-mesh sieve;

[0044] Step 3. After mixing the mixture of Step 1 and Step 2 uniformly by the method of equal increments, the tablet can be directly compressed. The friability of the formula is 0.2%, which ensures the impact resistance of the tablet in the later transportation process, the disintegration time limit is within 2 minutes, and the taste is better, which is obviously better than other examples.

Embodiment 2

[0046] An etimicin sulfate effervescent tablet, its main components include 20% etimicin sulfate, 5% citric acid, 5% sodium carbonate, 0.3% aspartame, and 0.7% glycyrrhizin in weight percent , peach essence 2.5%, micronized silica gel 1%, and the rest is anhydrous lactose.

[0047] Preparation:

[0048] Step 1. Etimicin sulfate powder and 1 / 3 anhydrous lactose are mixed uniformly in equal increments;

[0049] Step 2. Mix citric acid, sodium carbonate, aspartame, glycyrrhizin, peach essence, orange, micronized silica gel and 2 / 3 anhydrous lactose in equal increments and pass through a 200-mesh sieve;

[0050] Step 3. After mixing the mixture of Step 1 and Step 2 uniformly by the method of equal increments, the tablet can be directly compressed. The friability of the formula is 0.6%, which ensures the impact resistance of the tablet during later transportation, the disintegration time is within 3 minutes, and the taste is suitable.

Embodiment 3

[0052] An etimicin sulfate effervescent tablet, the main components of which include 30% etimicin sulfate, 5% tartaric acid, 5% sodium bicarbonate, 3% disodium glycyrrhizinate, 2% orange flavor, Talc 2.5%, the rest is anhydrous lactose.

[0053] The friability of the formula is 0.9%, the disintegration time limit is within 3 minutes, and the taste is suitable.

[0054] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a preparation method of an etimicin sulfate effervescent tablet, the etimicin sulfate effervescent tablet comprises the following components in percentage by weight: 10%-20% of etimicin sulfate, 0.1%-5% of organic acid, 0.1%-5% of inorganic base, 0.01%-5% of a flavoring agent, 0.5%-5% of a lubricant and the balance of a filler, and the preparation method is a direct powder tabletting method, which comprises the following steps: 1) uniformly mixing etimicin sulfate fine powder and lactose anhydrous in an equivalent incremental manner; 2) uniformly mixing the organic acid, the inorganic base, the flavoring agent, the lubricant and the residual filler in an equivalent incremental manner, and sieving by a 200-mesh sieve; and 3) uniformly mixing the mixture obtained in the step 1) and the mixture obtained in the step 2) according to an equivalent incremental method, and then directly tabletting, with the surface pressure of the tablet being 600-1000 MPa.

Description

Technical field: [0001] The invention relates to the field of pharmaceutical preparations for infection treatment, in particular to a preparation method of etimicin sulfate effervescent tablets. Background technique [0002] Etimicin sulfate is an aminoglycoside antibiotic. Our products are mainly injections, which are mainly used for Escherichia coli, Klebsiella pneumoniae, Serratia, Citrobacter, Enterobacter, Acinetobacter, Proteus, Haemophilus influenzae , Pseudomonas aeruginosa and Staphylococcus and other infections caused by Gram-negative bacteria such as respiratory tract, digestive tract, genitourinary system, skin and soft tissue, bone and joints, abdominal cavity, trauma and other infection, also suitable for sepsis. However, injections are high-risk dosage forms, and their use is greatly restricted. At the same time, the introduction of various policies of "restricting infusions" has also greatly restricted the use of injections. Oral preparations are convenient...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K47/12A61K47/02A61K47/28A61K47/26A61K31/7036A61P31/04
CPCA61K9/0007A61K9/2095A61K9/2013A61K9/2009A61K9/2018A61K31/7036A61P31/04
Inventor 俞婷王丹丹周雪姣高华娟
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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