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Tissue repairing membrane and preparation method thereof, and prepared drug-loaded tissue repairing membrane

A tissue repairing and drug-carrying technology, which is applied in the fields of medical science, drug devices, and other medical devices, can solve the problems of destroying the structure of drugs, and the compatibility of materials for one or a limited number of drugs, so as to achieve convenient preparation and use, Avoid drug modification, the effect of good clinical application value

Active Publication Date: 2017-11-03
MEDPRIN REGENERATIVE MEDICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the current research, the drug must be added to the raw material when the product is prepared (such as adding the drug to the spinning solution during electrospinning), and the drug will inevitably undergo organic solvents, pH changes, temperature changes, and long-term storage, which will destroy the drug. process of structure
At the same time, adding the drug to the repair material in advance will be affected by the combination of the drug and the repair material. Only one or a limited number of drugs can be combined according to the repair material, which has certain limitations in clinical application.

Method used

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  • Tissue repairing membrane and preparation method thereof, and prepared drug-loaded tissue repairing membrane
  • Tissue repairing membrane and preparation method thereof, and prepared drug-loaded tissue repairing membrane
  • Tissue repairing membrane and preparation method thereof, and prepared drug-loaded tissue repairing membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] PLA / Gelatin Tissue Repair Membrane

[0050] S1. Add 0.8g of polylactic acid into 10mL of hexafluoroisopropanol solution, stir at room temperature until dissolved, and make an 8% (w / v) spinning solution; add 1g of gelatin into 10mL of deionized water, and stir at room temperature until Dissolved to make a 10% (w / v) precursor solution;

[0051] S2. Slowly drop the gelatin precursor solution into a high-speed stirring ethanol solution to precipitate, distill under reduced pressure to remove the ethanol, and grind the obtained precipitate into powder to obtain gelatin particles;

[0052] S3. Add the spinning solution into the syringe, add an extension tube to the front of the syringe and connect a 20G needle, place the syringe on the micro-injection pump, the needle is perpendicular to the receiving plate, and the lower part of the receiving plate is grounded; set the injection rate to 2mL / h , when the solution is extruded from the needle tip, a voltage of 22kv is applied ...

Embodiment 2

[0057] PLA / Hyaluronic Acid Tissue Repair Membrane

[0058] S1. Add 0.6g of polycaprolactone into 10mL of hexafluoroisopropanol solution, stir at room temperature until dissolved to make a 6% (w / v) spinning solution; add 0.1g of hyaluronic acid into 10mL of deionized In water, stir at room temperature until dissolved to make a 1% (w / v) precursor solution; configure 30mM EDC-ethanol solution as a cross-linking agent;

[0059] S2. Pour the hyaluronic acid precursor solution into a 9mm Petri dish, freeze at -20°C to form a pre-frozen block with a thickness of 1.5mm, freeze-dry to obtain a hyaluronic acid freeze-dried sponge, and transfer the freeze-dried sponge to a cross-linking agent for processing After 30 minutes, take it out, wash it repeatedly with water to remove the cross-linking agent, and freeze-dry it again to obtain the hyaluronic acid drug storage layer;

[0060] S3. Add the spinning solution into the syringe respectively, add an extension tube to the front end of th...

Embodiment 3

[0065] PLA-PHBV / chitosan tissue repair membrane

[0066] S1. Add 0.8g polylactic acid into 10mL hexafluoroisopropanol solution, stir at room temperature until dissolved, and make 8% (w / v) spinning solution; add 2g polylactic acid into 10mL hexafluoroisopropanol solution Add 0.4g polyhydroxybutyrate valeric acid copolyester into 10mL chloroform solution, stir until dissolved at room temperature to make 4% (w / v) w / v) spinning solution; add 0.25g chitosan to 10mL of 2% acetic acid solution, stir at room temperature until dissolved to make a 0.025% (w / v) precursor solution; configure 2% glutaraldehyde solution as a cross-linking agent;

[0067] S2. Pour the chitosan precursor solution into a 9mm petri dish to form a block with a thickness of 3mm, add 16mL cross-linking agent, treat at 50°C for 1h, transfer to room temperature and continue processing for 48h to form chitosan hydrogel, use buffer solution to adjust the pH to 7.0, repeatedly washed with water to remove the crosslin...

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Abstract

The invention discloses a preparation method for a drug-loadable tissue repairing membrane. The drug-loadable tissue repairing membrane comprises an electrospun fibrous membrane main body, at least one hermetic drug storage chamber formed in the electrospun fibrous membrane main body and a drug storage medium arranged in the drug storage chamber, wherein the electrospun fibrous membrane main body is prepared from a hydrophobic degradable material, and the drug storage medium is prepared from a hydrophilic degradable material. According to the tissue repairing membrane in the invention, the drug storage medium is wrapped in the electrospun fibrous membrane main body, and a drug solution can be injected into the drug storage medium before usage of the tissue repairing membrane so as to realize the drug loading and sustained drug releasing functions of the tissue repairing membrane, so the tissue repairing membrane is simple and convenient to use and prevents destroy of factors like organic solvents in conventional drug loading methods to drugs; moreover, the tissue repairing membrane can realize in-situ long-term stable drug delivery during tissue repairing, does not need to take out, is simple to operate and has good clinical application value in the field of tissue repairing.

Description

technical field [0001] The invention belongs to the field of tissue repair membranes and drug sustained release, and in particular relates to a tissue repair membrane, a preparation method thereof and a prepared drug-loaded tissue repair membrane. Background technique [0002] For tissue defects caused by trauma, accidents, cancer, etc., there are many clinically used repair products, such as the same / heterogeneous acellular matrix products, freeze-dried products, electrospinning products, etc. Among them, electrospun products are composed of nanofibers, which have good application effects in the field of tissue repair due to their advantages such as nanoscale, high specific surface area, and simulated extracellular matrix. However, regardless of whether the prosthetic product is made of natural materials or polymer synthetic materials, there will always be a foreign body immune response after implantation. Sometimes the foreign body immune response is too severe, and there ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/58A61L27/50A61L27/22A61L27/20A61L27/18A61F2/00A61M37/00
CPCA61F2/00A61L27/18A61L27/20A61L27/222A61L27/50A61L27/54A61L27/58A61L2300/604A61M37/00C08L67/04C08L5/08
Inventor 张海涛邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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