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Polylactic acid composite biological tissue repair material and preparation method thereof

A technology for repairing materials and biological tissues, applied in medical science, prostheses, etc., can solve problems such as poor medicinal properties and poor mechanical properties, and achieve the effect of increasing physical and mechanical properties and improving tissue repair ability.

Inactive Publication Date: 2017-09-15
WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, bioactive glass has attracted extensive attention due to its good tissue repair ability, osteoconductivity, osteoinductivity, and biodegradability, but its poor mechanical properties and poor medicinal properties

Method used

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  • Polylactic acid composite biological tissue repair material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A polylactic acid composite biological tissue repair material, which is composed of the following raw materials in mass percentage: polylactic acid 30%, mesoporous nano-bioactive glass 20%, tetrahydrofuran 41%, Chinese herbal medicine extract 5%, green tea extract 2%, hyaluronic acid Sodium phosphate 1%, allantoin 1%.

[0022] The mesoporous nano-bioactive glass is prepared by the following method: 15g of cetyltrimethylammonium bromide is dissolved in 500ml of deionized water at 35°C, 3.9g of tetraethyl orthosilicate and 3.54g of Ca(NO 3 ) 2 4H 2 O, adjust the pH to 2 with nitric acid, after hydrolysis for 4 hours, add 0.435gNH 4 h 2 PO 4 and use NH 3 ·H 2 O to adjust the pH to 10. After reacting for 12 hours, raise the temperature to 95° C. for precipitation for 48 hours, centrifuge the reaction solution, wash it repeatedly with deionized water, and freeze-dry to obtain mesoporous nano-biologically active glass.

[0023] The Chinese herbal medicine extract is Sa...

Embodiment 2

[0032] A polylactic acid composite biological tissue repair material, characterized in that it is composed of the following raw materials in mass percentage: polylactic acid 35%, mesoporous nano-biologically active glass 24%, tetrahydrofuran 35%, Chinese herbal medicine extract 3%, green tea extract 1 %, sodium hyaluronate 1%, allantoin 1%.

[0033] The mesoporous nano-bioactive glass is prepared by the following method: 15g of cetyltrimethylammonium bromide is dissolved in 500ml of deionized water at 35°C, 3.9g of tetraethyl orthosilicate and 3.54g of Ca(NO 3 ) 2 4H 2 O, adjust the pH to 2 with nitric acid, after hydrolysis for 4 hours, add 0.435gNH 4 h 2 PO 4 and use NH 3 ·H 2 O to adjust the pH to 10. After reacting for 12 hours, raise the temperature to 95° C. for precipitation for 48 hours, centrifuge the reaction solution, wash it repeatedly with deionized water, and freeze-dry to obtain mesoporous nano-biologically active glass.

[0034] The Chinese herbal medici...

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Abstract

A polylactic acid composite biological tissue repair material and a preparation method thereof belong to the field of composite biological materials. The polylactic acid composite biological tissue repair material consists of the following raw materials by mass percent: 30-35% of polylactic acid, 20-25% of mesoporous nano-bioactive glass, 35-45% of tetrahydrofuran, 3-5% of a Chinese herb extract, 1-2% of a green tea extract, 1-2% of sodium hyaluronate and 1-2% of allantoin. The polylactic acid composite biological tissue repair material has favorable mechanical performance and an excellent medicinal effect.

Description

technical field [0001] The invention belongs to the field of composite biological materials, in particular to a polylactic acid composite biological tissue repair material and a preparation method thereof. Background technique [0002] Poly lactic acid (PLA) is generally produced through artificial synthesis and does not exist in nature. Lactic acid as a raw material is fermented from monosaccharides. Polylactic acid is an aliphatic polyester, and polylactic acid with high relative molecular weight can be obtained by cyclic dimer lactide polymerization of lactic acid or direct polymerization of lactic acid. Lactic acid has three optical isomers of left-handed (L), right-handed (D) and meso due to the presence of a methyl group at the α-position. PLLA has excellent mechanical strength and a long time for degradation and absorption (generally 3-3.5 years), and is suitable for making bone fixation devices. Polylactic acid has good biodegradability, but also has good bioabsorb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/18A61L27/10A61L27/20A61L27/50A61L27/54A61L27/56
Inventor 张春松吴长应
Owner WUHU YANGZHAN NEW MATERIAL TECH SERVICE CO LTD
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