The invention relates to a traditional Chinese medicine oral liquid for treating leukemia, which is prepared by the following medicines in parts by weight: 1-10 parts of antelope's horn, 0.5-5 parts of bezoar, 1-10 parts of resina draconis, 10-200 parts of honeysuckle, 5-40 parts of largehead atractylodes rhizome, 10-40 parts of poria cocos, 10-80 parts of oldenlandia, 10-40 parts of radix ranunculi ternate, 5-30 parts of powdery paris polyphylla, 5-30 parts of edible tulip, 0.01-0.1 parts of arenobufagin, 2-20 parts of American ginseng, 2-10 parts of indigo naturalis, 3-10 parts of panax notoginseng, 5-20 parts of fructus lycii, 1-10 parts of cordyceps sinensis, 2-20 parts of flos carthami, 5-30 parts of angelica sinensis, and 5-20 parts of hippocampus. The traditional Chinese medicine oral liquid is prepared by adding an approximate amount of water into the abovementioned high-quality traditional Chinese medicinal materials to decoct for 30 minutes, obtaining the decoction after filtrating, repeatedly decocting the traditional Chinese medicinal materials for three times in this way, and obtaining the traditional Chinese medicine oral liquid for treating leukemia after concentrating and filling the liquid medicine filtered out at three times into bottles. The traditional Chinese medicine oral liquid has the advantages of being good in curative effect, free from relapse and tolerance, and low in toxic and side effects.