40results about How to "Sufficient dynamic range" patented technology

An electronic circuit, which has transistors disposed on a substrate, each transistor including an active layer made of thin-film polysilicon, includes a sensor that converts a measured quantity into a current value, a current-voltage conversion circuit that converts the current value into a voltage, and a voltage detection circuit that detects the voltage converted by the current-voltage conversion circuit and outputs a predetermined signal. The current-voltage conversion circuit includes a storage circuit and a range-switching circuit that switches a current-voltage conversion range of the current-voltage conversion circuit by switching the capacitance of the storage circuit.

Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a housing including an internal area, a container configured to hold a fluid sample at a sample position in a light tight manner within the internal area of the housing, a light source configured to project light onto the fluid sample within the container, and an optical sensor configured to move between different sensor positions while the fluid sample remains stationary at the sample position, the different sensor positions including at least two of: (i) a first sensor position for taking a luminescence reading of the fluid sample; (ii) a second sensor position for taking a dark current or other background measurement; and (iii) a third sensor position for taking a fluorescence reading of the fluid sample.

Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a pipette having a tip, the pipette configured to aspirate a fluid sample and hold the fluid sample within the tip, a housing including a reentrant seal and an internal area, the housing configured to receive at least the tip of the pipette through the reentrant seal so that the tip of the pipette is located in a light tight manner within the internal area, a light source positioned to be in proximity to the tip of the pipette when the tip of the pipette is received by the housing, the light source configured to project light through the tip of the pipette and onto the fluid sample held within the tip, and an optical sensor configured to take a reading of the fluid sample held within the tip of the pipette without any of the fluid sample being injected from the pipette.

An electronic circuit, which has transistors disposed on a substrate, each transistor including an active layer made of thin-film polysilicon, includes a sensor that converts a measured quantity into a current value, a current-voltage conversion circuit that converts the current value into a voltage, and a voltage detection circuit that detects the voltage converted by the current-voltage conversion circuit and outputs a predetermined signal. The current-voltage conversion circuit includes a range-switching circuit that switches a current-voltage conversion range.

Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound compounds are rinsed from the extraction devices using a series of buffer and water rinses, after which the wild type protein (and / or its variants) are eluted directly onto a target in preparation for analysis such as matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS). Mass spectrometry of the eluted sample then follows with the retained proteins identified via accurate molecular mass determination. Protein and variant levels can be determined using quantitative methods in which the protein / variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to a working curves constructed from samples containing known concentrations of the protein or variants. Such MSIA devices, kits and methods have significant application in the fields of; basic research and development, proteomics, protein structural characterization, drug discovery, drug-target discovery, therapeutic monitoring, clinical monitoring and diagnostics, as well as in the high throughput screening of large populations to establish and recognize protein / variant patterns that are able to differentiate healthy from diseased states.

The invention relates to a tuneable AWG device for multiplexing and demultiplexing signals and to a method for tuning said device. The inventive device is an integrated-optic device which enables a signal made up of a plurality of signals multiplexed by wavelength division to be injected through an input port such as to obtain, at the output, a demultiplexed signal with each component exiting via a different port. If the multiplexed signal is changed to another input port, the demultiplexed signals appear at different ports, but always according to a pre-determined relationship. The invention makes it possible to tune the AWG device by using stationary acoustic waves such that the acoustically excited optical guides are excited by a linear acoustic wave.

Apparatus and methods disclosed herein perform gain, clipping, and phase compensation in the presence of I / Q mismatch in quadrature RF receivers. Gain and phase mismatch are exacerbated by differences in clipping between I & Q signals in low resolution ADCs. Signals in the stronger channel arm are clipped differentially more than weaker signals in the other channel arm. Embodiments herein perform clipping operations during iterations of gain mismatch calculations in order to balance clipping between the I and Q channel arms. Gain compensation coefficients are iteratively converged, clipping levels are established, and data flowing through the network is gain and clipping compensated. A compensation phase angle and phase compensation coefficients are then determined from gain and clipping compensated sample data. The resulting phase compensation coefficients are applied to the gain and clipping corrected receiver data to yield a gain, clipping, and phase compensated data stream.

A method of manufacturing a solid-state imaging device. Light-receiving sensor portions each constituting a pixel in the form of a matrix is arranged. The matrix has columns aligned in a vertical direction and rows aligned in a horizontal direction. Charge-transfer portions are formed on either side of the columns of said pixels. Transfer electrodes in said charge-transfer portions are formed to include a first transfer electrode formed of a first electrode layer and a second transfer electrode formed by electrically connecting the first electrode layer and a second electrode layer through a contact. The second transfer electrode being disposed in the vertical direction above the charge-transfer portion in a vicinity of the contact to decrease the width of the charge-transfer portions in the horizontal direction and increase the light receiving sensor portions in the vertical direction.

An apparatus and method for detecting beam power generated by a plurality of light sources, using a single device. The apparatus includes a light-receiving unit that receives the beam power generated by one of a plurality of light sources, and an amplifying unit that selects a gain, amplifies the beam power received by the light-receiving unit according to the selected gain, and outputs the beam power amplified as a detected beam power. According to the apparatus and method, received beam power (or amplification gain) is amplified by a gain determined according to the characteristics of the respective light sources. Thus, it is possible to provide the detected beam power in consideration of a sufficient dynamic range for the each light source, thereby realizing effective APC.

A method of performing cancellation for acoustic or electromagnetic measurement or communications includes receiving an output signal to be applied to a transmit transducer, introducing a delay to the output signal to produce a delayed output signal, applying the delayed output signal to the transmit transducer, receiving an input signal from a receiving transducer, wherein the input signal comprises at least a portion of the delayed output signal, and iteratively solving a Kalman filter problem as a function of the input signal, the output signal, and the delay to produce a first filtered input signal.

The present invention provides an image reading apparatus capable of reading images with a sufficiently wide dynamic range. An image reading apparatus of this invention has a light source, a reading section which generates image data based on light obtained from an original illuminated with light from the light source, a first level changing section which changes a light receiving level in the reading section in a first manner, a second level changing section which changes the light receiving level in a second manner different from the first manner, a control section in which plural light receiving levels are generated by synergistically changing a light receiving level, and a combining section which combines plural image data obtained by reading an image of an original at plural light receiving levels.

Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein / variant signals are normalized to signals of internal reference standard species (either doped into the samples prior to the MSIA analysis, or other endogenous protein co-extracted with the target proteins) and the values compared to working curves constructed from samples containing known concentrations of the protein or variants.