The invention discloses a pesticide combination containing spinetoram and pyridaben, and belongs to the technical field of pesticides. The pesticide combination is prepared from the combination of the spinetoram, the pyridaben, fluorine silicon iodine, sodium humate, rh-5849, trifloxysulfuron sodium, ethrimol, coumaphos, 41% isopropylamine salt of N-glycine, benzenesulfonic acid emulsifying agents and benzene hydrocarbon. To obtain pesticide combination finished products, assistant agents of the pesticide combination containing the spinetoram and the pyridaben, dispersing agents, adjuvant, simethicone and water are needed, and the weight radio of the spinetoram to the pyridaben to the rh-5849 is 10: 4: 1. According to the pesticide combination, the two agents with totally different action mechanisms are blended, combined actions can be conducted on pests in many ways, and the purpose of effective control over the pests is achieved; meanwhile, the using dosage of the agents in field is reduced, the economic cost is saved, the pollution of the agents to the environment is reduced, and the risk that the pests develop resistance to the agents is also lowered.