The invention discloses a mobile robustness optimization method and device based on mobile state information and adjacent region proximity and belongs to the technical field of wireless communication. In the method, a micro base station controller estimates real-time mobile state information of mobile UE according to cyclic measuring reports obtained from the mobile UE; then the mobile UE is subjected to switching control according to an adjacent region deploying environment, and frequent switching between a macrocell and a microcell of the mobile UE is avoided; and finally, during a switching process, switching preparing operation to a preparing target cell is brought forward, and according to the moving speed of the mobile UE and the PDCCH interruption point of the service microcell, the switching condition for avoiding ping-pong switching is computed. Compared with the prior art, the prediction success rate of the preparing target cell is improved, frequency spectrum resource using rate is improved, frequent switching between the macrocell and the microcell of the mobile UE is lowered, then network signaling expenditure is reduced, SToS rate is not increased, meanwhile, the switching success rate of the mobile UE can be improved, and then user experience is improved.