32results about How to "Good specific binding ability" patented technology

The present invention relates to a hybridoma cell strain and a monoclonal antibody secreted thereof, the monoclonal antibody can specifically bind to human IgM and can be used for in vitro detection of the human IgM, and is particularly suitable for early diagnosis of mumps virus infection. The invention also relates to a kit comprising the hybridoma cell strain or the monoclonal antibody.

The invention relates to a hybridoma cell strain and a monoclonal antibody secreted by the hybridoma cell strain. The antibody can be specifically bound with human IgM, and can be used for in-vitro detection of the human IgM, and especially suitable for the early diagnosis of hepatitis E virus infection. The invention further relates to a kit containing the hybridoma cell strains or the monoclonalantibodies.

The present invention provides an anti-TIGIT monoclonal antibody and application thereof, the anti-TIGIT monoclonal antibody comprises a heavy chain variable region and a light chain variable region; the heavy chain variable region comprises SEQ ID NO:1 The heavy chain CDR1, the heavy chain CDR2 shown in SEQ ID NO:2 and the heavy chain CDR3 shown in SEQ ID NO:3; the light chain variable region includes the light chain CDR1 shown in SEQ ID NO:4, SEQ ID NO:4 Light chain CDR2 shown in ID NO:5 and light chain CDR3 shown in SEQ ID NO:6. The anti-TIGIT monoclonal antibody of the invention has strong specific recognition and binding ability to the antigen TIGIT, can effectively block the combination of TIGIT and its ligand CD155, and has broad application prospects.

The invention relates to a specific polypeptide targeting and binding to lymphoid cancer cell lines and its application, which belongs to the field of biomedicine; the invention is based on in vitro phage display technology, and the specific polypeptide TUZG12 capable of targeting and binding to lymphoid cancer cell lines is obtained by panning in vitro In vitro cell uptake and distribution experiments prove that the polypeptide has targeted binding activity to lymphoma cell lines; the present invention also shows through in vitro cell activity experiments that pro-apoptotic peptide DKK coupled with TUZG12 polypeptide can improve to a certain extent The inhibitory effect of DKK on the proliferation activity of lymphoma cells; the polypeptide screened by the present invention has good targeting binding activity to multiple lymphoma cell lines, and can improve the killing effect of cytotoxic polypeptides on target tumor cells. It has important application value in diagnosis and treatment.

The invention relates to a hybridoma cell strain and a secreted monoclonal antibody thereof; the antibody can be specifically combined with a human IgM, and can be used for in vitro detection of the human IgM, and particularly suitable for early diagnosis of measles virus infection. The invention further relates to a kit comprising the hybridoma cell strain or the monoclonal antibody.

The invention relates to an anti-cryptococcus capsular polysaccharide hybridoma cell line and the anti-cryptococcus capsular polysaccharide monoclonal antibody secreted therein, the antibody can specifically bind to the cryptococcal capsular polysaccharide, and can be used for in vitro detection of cryptococcal infection , its antibody titer is as high as more than one million, has excellent affinity, and has good specific binding ability; the detection limit of the colloidal gold-labeled immunodiagnostic reagent developed with this antibody as a raw material is 0.5ng / ml, in terms of sensitivity, Specificity, stability, all aspects of the antibody have better performance.

The invention relates to a hybridoma cell strain and a monoclonal antibody secreted by the hybridoma cell strain. The antibody can be specifically bound with human IgM, and can be used for in-vitro detection of the human IgM, and especially suitable for the early diagnosis of cytomegalovirus infection. The invention further relates to a kit containing the hybridoma cell strains or the monoclonal antibodies.

The invention relates to a hybridoma cell strain and a monoclonal antibody secreted by the hybridoma cell strain. The antibody can realize the specific combination with the human IgM, can be used forhuman IgM in-vitro detection, and is particularly suitable for being used for early diagnosis of hepatitis B virus. The invention also comprises a kit comprising the hybridoma cell strain or the monoclonal antibody.