The invention relates to a medicine used for treating pressure-ulcer, and specifically relates to a pressure-ulcer medicine and a preparation method thereof. The pressure-ulcer medicine is prepared from pearl powder, mud eel blood, aloe juice, officinal magnolia flower, sophora subprosstratae, divaricate saposhnikovia, salvia miltiorrhiza, redroot gromwell, and badger fat. The main components are officinal magnolia flower, sophora subprosstratae, and salvia miltiorrhiza. When the three medicine materials are used together, functions such as inflammation elimination, pain relieving, dampness elimination, itching relieving, stasis removing, and swelling subsiding are provided. Also, the mud eel blood, aloe, divaricate saposhnikovia, redroot gromwell, badger fat, and pearl powder are used in auxiliary, such that functions such as bleeding stopping, detoxifying, tissue regeneration promoting, and skin penetration maintaining are added on a basis of the enhancements on dampness eliminating and heat clearing functions. Therefore, skin red swelling caused by radiation dermatitis and chemotherapy medicine extravasation can be rapidly eliminated, and ulcer wound healing can be promoted.