The invention relates to a medicated wine for treating rheumatism, and belongs to the technical field of preparation of medicated wines for treating rheumatism. A preparation method of the medicated wine comprises the following steps: crushing Chinese herbal medicines including Chinese angelica, incised notopterygium, root of doubleteeth pubescent angelica, divaricate saposhnikovia root, stem or root of oblongleaf kadsura, giantleaf ardisia rhizome, fortune's drynaria rhizome, common clubmoss herb, Chinese taxillus twig, Chinese ivy stem and the like into 50-mesh broken powder, then feeding into a ceramic or glass vessel, directly adding a 60-degree distilled spirit for soaking, stirring once per day, and performing filtration by using a 200-mesh filter screen to prepare the medicated wine after soaking for 30-40 days. The medicated wine for treating rheumatism, disclosed by the invention, can be used for treating rheumatism by using a scientific prescription and using the comprehensive synergistic effects of the Chinese herbal medicines, cannot cause toxicity and harms to a human body, does not need to be decocted, can be used for directly reaching sick parts, and is simple and convenient to drink, low in cost and significant in curative effect; and by adopting the medicated wine, the problems that an existing orally-taken medicine adopted for treating rheumatism does not have significant curative effects on focuses, has a very high relapse rate after medicine withdrawal, can cause side effects including nausea, emesis, decreased food appetite, tinnitus and the like after being taken for a long time, and can cause damages to the functions of the liver, the kidneys, the stomach and the like can be solved.