41results about "Monocomponent polypeptides artificial filament" patented technology

A method of forming a fiber made of peptide nanostructures is disclosed. The method comprises: providing peptide nanostructures in solution, and fiberizing the solution thereby forming at least one fiber of the peptide nanostructures. Also disclosed are methods of forming films and other articles using the peptide nanostructures.

The invention relates to a preparation method of water stability gamma-polyglutamic acid nanometer fibers. The preparation method comprises the steps of: (1) preparing trifluoroacetic acid water solution of which the mass percentage concentration is 5%-10%, dissolving gamma-polyglutamic acid in the trifluoroacetic acid solution and stirring the solution for 6-8 hours to obtain gamma-polyglutamic acid solution; (2) spinning the gamma-polyglutamic acid solution via static spinning to obtain gamma-polyglutamic acid nanometer fibers; and (3) dissolving the gamma-polyglutamic acid nanometer fibersand EDC (ethylene dichloride) in methanol to have a reaction at room temperature for 3-5 hours, adding cystamine dihydrochlorid to have a reaction for 48-72 hours after the reaction is ended, rinsing, freezing and drying the products after the reaction of cystamine dihydrochlorid is ended, thus obtaining gamma-polyglutamic acid nanometer fibers with good water stability. The preparation method ofthe water stability gamma-polyglutamic acid nanometer fibers is simple and convenient in operation and has moderate technique conditions; the raw materials are easy to obtain, and the prepared gamma-polyglutamic acid nanometer fibers have good biocompatibility so the gamma-polyglutamic acid nanometer fibers have latent application merits in the field of the histological engineering bracket.

Piezoelectric fibers include a polypeptide wherein molecules of the polypeptide have electric dipole moments that are aligned such that the piezoelectric fiber provides a piezoelectric effect at an operating temperature. A piezoelectric component provides a plurality of piezoelectric fibers, each comprising an organic polymer. A method of producing piezoelectric fibers includes electrospinning a polymer solution to form a fiber and winding the fiber onto a rotating target in which the rotating target is electrically grounded. An acoustic sensor includes a plurality acoustic transducers, wherein the plurality of acoustic transducers are structured and arranged to detect a corresponding plurality of vector components of an acoustic signal, and at least one of the plurality of acoustic transducers comprises a piezoelectric fiber.

A modified fibroin includes a domain sequence indicated by formula 1: [(A)nmotif-REP]m. The domain sequence has an amino acid sequence having a reduced (A)nmotif content compared to naturally-derivedfibroin, said reduction being equivalent to the deletion of at least one (A)nmotif. [In formula 1, (A)nmotif indicates an amino acid sequence comprising 4-20 amino acid residues. The number of alanineresidues relative to the total number of amino acid residues in (A)nmotif is at least 83%. REP indicates an amino acid sequence comprising 10-200 amino acid residues. m indicates an integer between 8and 300. A plurality of (A)nmotif etc., may be the same amino acid sequence or different amino acid sequences.]

A bimodal bioabsorbable polymer composition. The composition includes a first amount of a bioabsorbable polymer polymerized so as to have a first molecular weight distribution; a second amount of said bioabsorbable polymer polymerized so as to have a second molecular weight distribution having a weight average molecular weight between about 10,000 to about 50,000 Daltons, the weight average molecular weight ratio of said first molecular weight distribution to said second molecular weight distribution is at least about two to one; wherein a substantially homogeneous blend of said first and second amounts of said bioabsorbable polymer is formed in a ratio of between about 50 / 50 to about 95 / 5 weight / weight percent. Also disclosed are a medical device, a method of making a medical device and a method of melt blowing a semi-crystalline polymer blend.

An artificial polypeptide fiber of the present invention is an artificial fiber containing a polypeptide as a main component, and has a stress of 350 MPa or more and a toughness of 138 MJ / m3 or more. A method for producing an artificial polypeptide fiber of the present invention is a method for producing the artificial polypeptide fiber obtained by spinning a spinning solution (6) containing a polypeptide derived from natural spider silk proteins and performing drawing of at least two stages. The drawing of at least two stages includes a first-stage drawing (3) in wet heat and a second-stage drawing (4) in dry heat. Thereby, the present invention provides high-toughness artificial polypeptide fibers having favorable stress and rupture elongation, and a method for producing the same.

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field can be applied to electrospin the at least one polypeptide.

A water-insoluble polyglutamic acid (PGA) fiber and a preparation method thereof are provided. In the preparation method, the PGA is cross-linked by a cross-linking agent and then passes through a spinning nozzle to form PGA fibers. Therefore, the highly water-absorbing PGA, which cannot be spun by conventional methods, can be spun to form PGA fibers and maintain the high water-absorption ability.

Disclosed is a method for purifying a recombinant protein from a recombinant cell in which a target recombinant protein is expressed within the cell as an insoluble body, said method characterized inthat said recombinant cell is treated under conditions in which a protein derived from a host cell would dissolve, but said recombinant protein would not dissolve, in a first aprotic polar solvent towhich an inorganic salt has been added or not added, a first soluble fraction is removed, and then an obtained first insoluble fraction is treated under conditions in which the recombinant protein would dissolve in a second aprotic polar solvent to which an inorganic salt has been added.

The subject invention pertains to peptide-based materials comprising cross-linked peptides with random amino acid sequences that are soluble in water or ethanol before crosslinking but insoluble in water after crosslinking.

The subject invention pertains to peptide-based materials comprising cross-linked peptides with random amino acid sequences that are soluble in water or ethanol before crosslinking but insoluble in water after crosslinking.

Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.

Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected L-leucine, L-isoleucine, L-valine or combinations thereof. The amino acid-based poly(ester urea)S may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids. The amino acid-based poly(ester urea)s are particular useful for the preparation of vascular grafts. Due to the biocompatibility of the amino acid-based poly(ester urea)s, vascular grafts prepared from amino acid-based poly(ester urea)s with small internal diameters (i.e. less than 5 mm) may be prepared and inserted into a patient or animal, and provide a substantial decrease in the risk of failure compared to conventional polymers used in vascular grafts.