A compound of general formula (1) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are H or methyl, R13, R14, R15 and R16 are H or
alkyl, wherein L1 and L2 are linkers selected from
single bond, methyl, ethyl, wherein R19, R20 and R21 are H or —CH2X, NT is selected from H, hydroxyl,
alkyl, aminoacid, aminoacid analogue, polypeptide and functional group, CT is selected from
hydrogen, hydroxyl,
alkyl, aminoacid, aminoacid analogue, polypeptide and functional group shows
high selectivity and high affinity for MC1-receptors in combination with effective stimulation or inhibiton of cAMP formation in MC1-
receptor expressing cells but
low affinity for other subtypes of MC-receptors and may be used to treat a wide range of inflammatory conditions. Also disclosed is
a DNA molecule and a corresponding vector encoding the compound, a
fusion protein comprising a copy of it, a vector comprising
DNA encoding the
fusion protein, and a pharmaceutical composition comprising the compound.