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76results about "Crystallising dishes" patented technology
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Microfluidic chemical reactor for the manufacture of chemically-produced nanoparticles
InactiveUS20050129580A1Maintain propertiesMaterial nanotechnologyPolycrystalline material growthProcess functionNanoparticle
The present invention discloses microfluidic modules for making nanocrystalline materials in a continuous flow process. The microfluidic modules include one or more flow path with mixing structures and one or more controlled heat exchangers to process the nanocrystalline materials and reagents in the flow path. The microfluidic modules can be interconnected to form microfluidic reactors that incorporate one or more process functions such as nucleation, growth, and purification.
Owner:LAKE SHORE CRYOTRONICS INC
Microfluidic system
ActiveUS20060094119A1Rapid and economical reactionIncrease rangePolycrystalline material growthAnalysis using chemical indicatorsFemtoliterEngineering
Owner:CHICAGO UNIV OF
Method of electrowetting droplet operations for protein crystallization
InactiveUS7763471B2Easy to useFacilitates of propertySamplingBiological testingChemical physicsActuator
Methods of using protein crystallization droplet actuators are provided. Protein sample droplets and reagent droplets are dispensed, transported, and merged to yield an array of crystallization conditions by electrowetting droplet operations in a gap comprising oil filler fluid. The oil filler fluid is doped with a surfactant that enhances droplet operations using the protein sample.
Owner:ADVANCED LIQUID LOGIC +1
Protein Crystallization Droplet Actuator, System and Method
InactiveUS20080050834A1High resolutionHigh sensitivityPreparing sample for investigationBiological testingActuatorReagent
Protein crystallization droplet actuators, systems and methods are provided. According to one embodiment, a droplet actuator for providing an array of crystallization conditions is provided and includes: (a) two or more processing reservoirs; (b) two or more dispensing reservoirs collectively comprising two or more crystallization reagents; and (c) a port for introducing a sample for crystallization analysis. Systems including the droplet actuator, methods of providing an array of crystallization conditions, and methods of identifying crystallization conditions are also provided.
Owner:ADVANCED LIQUID LOGIC +1
Crystal forming devices and systems and methods for using the same
ActiveUS20050201901A1Improve sealingFrom normal temperature solutionsAnalysis by subjecting material to chemical reactionActuatorBiomedical engineering
The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.
Owner:STANDARD BIOTOOLS INC
Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
ActiveUS7655470B2Rapid and economical reactionIncrease rangePolycrystalline material growthAnalysis using chemical indicatorsFemtoliterBiochemistry
Owner:CHICAGO UNIV OF
Microfluidic protein crystallography
InactiveUS20050205005A1High throughput screeningImprove throughputValve arrangementsPeptide librariesHigh-Throughput Screening MethodsAgent Combination
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
Owner:CALIFORNIA INST OF TECH
High throughput screening of crystallization of materials
InactiveUS7052545B2Sequential/parallel process reactionsFrom normal temperature solutionsHigh-Throughput Screening MethodsSize determination
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
Owner:RGT UNIV OF CALIFORNIA +1
Microfluidic protein crystallography techniques
InactiveUS20050062196A1Polycrystalline material growthFrom normal temperature solutionsDiffusionCrystalline materials
The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
Owner:CALIFORNIA INST OF TECH +1
High throughput screening of crystallization of materials
InactiveUS7195670B2From normal temperature solutionsFixed microstructural devicesHigh-Throughput Screening MethodsSize determination
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
Owner:CALIFORNIA INST OF TECH +1
Processes for identifying a solvent condition suitable for determining a biophysical property of a protein
The present invention provides processes for identifying a buffer condition suitable for determining a biophysical property of a protein. The processes of this invention utilize vapor diffusion means to alter buffer conditions, thus minimizing the volume of test samples and thereby conserving protein material. The processes of this invention are particularly useful to determine a buffer condition suitable for performing NMR studies on a protein.
Owner:VERTEX PHARMA INC
High throughput screening of crystallization of materials
InactiveUS20050229839A1Sequential/parallel process reactionsFrom normal temperature solutionsHigh-Throughput Screening MethodsSize determination
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.
Owner:CALIFORNIA INST OF TECH +1
Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and / or retains the selected molecules without affecting other molecules in the sample.
Owner:CYTONOMEST
Integrated chip carriers with thermocycler interfaces and methods of using the same
ActiveUS20070196912A1Bioreactor/fermenter combinationsBiological substance pretreatmentsHeat controlThermal cycler
Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.
Owner:STANDARD BIOTOOLS INC
Method for preparation of microarrays for screening of crystal growth conditions
InactiveUS7244396B2Slow evaporation rateMinimize controlFrom normal temperature solutionsHydrolasesCrystal growthMicrogram
A method of screening solution conditions suitable for the crystallization of macromolecules with a picogram to a microgram of protein using picoliter or nanoliter volumes is provided. A preferred method comprises preparing a plurality of recipe solutions in milliliter volumes, aspirating protein and recipe solutions, respectively, from a plurality of wells, and dispensing the protein and recipe solutions into a plurality of wells, covering the combined protein and recipe solutions with oil, and maintaining the solution wells until crystallization or precipitation occur therein.
Owner:UAB RES FOUND
Method for screening crystallization conditions in solution crystal growth
InactiveUS7214540B2Peptide librariesSequential/parallel process reactionsProtein solutionCrystal growth
A method of screening protein crystal growth conditions on a nano or meso scale comprises providing a micro-electromechanical chip with a plurality of micro-chambers in the micro-electromechanical chip. A protein solution is placed into the micro-chambers by an automated jet type dispensing means with nano or meso scale precision. The protein crystal growth conditions of each of the micro-chambers is adjusted so that the protein crystal growth conditions of each of the micro-chambers differs. Crystallization of the protein solution in the micro-chambers is effected. Protein crystal growth in the micro-chambers is then observed.
Owner:UAB RES FOUND
Microfluidic Device for Passive Sorting and Storage of Liquid Plugs Using Capillary Force
InactiveUS20080295909A1Promote partial polymerizationEasy transferSequential/parallel process reactionsFlow mixersMicrometerPhotopolymer
A three dimensional microfluidic device for passive sorting and storing of liquid plugs is provided with homogeneous surfaces from the exposure of a photopolymer through binary masking motifs, i.e., arrays of opaque pixels on a transparency mask. The device includes sub-millimeter three-dimensional relief microstructures to aid in the channeling of fluids. The microstructures have topographically modulated features smaller than 100 micrometers.
Owner:GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC OF COMMERCE THE NAT INST OF STANDARDS & TEHCNOLOGY
Method and apparatus for carbonylating methanol with acetic acid enriched flash stream
ActiveUS20090270650A1Improve concentrationShorten the purification processOrganic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsMetal catalystMethyl acetate
A carbonylation process for producing acetic acid including: (a) carbonylating methanol or its reactive derivatives in the presence of a Group VIII metal catalyst and methyl iodide promoter to produce a liquid reaction mixture including acetic acid, water, methyl acetate and methyl iodide; (b) feeding the liquid reaction mixture at a feed temperature to a flash vessel which is maintained at a reduced pressure; (c) heating the flash vessel while concurrently flashing the reaction mixture to produce a crude product vapor stream, wherein the reaction mixture is selected and the flow rate of the reaction mixture fed to the flash vessel as well as the amount of heat supplied to the flash vessel is controlled such that the temperature of the crude product vapor stream is maintained at a temperature less than 90° F. cooler than the feed temperature of the liquid reaction mixture to the flasher and the concentration of acetic acid in the crude product vapor stream is greater than 70% by weight of the crude product vapor stream.
Owner:CELANESE INT CORP
Methods and devices for high throughput crystallization
InactiveUS7229500B2Avoid large quantitiesHigh densityMaterial nanotechnologyPolycrystalline material growthNucleationPhotoresist
Crystallization Photoresist (PR) apparatus and methods which allow for fast screening and determination of protein crystallization conditions with small protein quantities and rapid crystallization. The apparatus comprise a first region comprising a first nucleation catalyst material and a second region comprising a second nucleation catalyst material, with the first and second regions positioned adjacent to each other and configured to support at least one crystal, and with the first region having a variation in a nucleation property of the first nucleation catalyst material in the first region. The crystal may be supported at an interface of the adjacent regions. The methods comprise providing a first region of a first nucleation catalyst material and a second region of a second nucleation catalyst material adjacent said first region, with the first region having a variation in a nucleation property of the first nucleation catalyst material, exposing the first and second regions to a solution of a selected molecule, and growing at least one crystal of the molecule in association with the first and second regions.
Owner:PARALLEL SYNTHESIS TECH
Method and apparatus for carbonylating methanol with acetic acid enriched flash stream
ActiveUS7820855B2Organic compound preparationOrganic-compounds/hydrides/coordination-complexes catalystsMetal catalystMethyl acetate
Owner:CELANESE INT CORP
Computer Controllable LED Light Source for Device for Inspecting Microscopic Objects
InactiveUS20090080611A1Material analysis using wave/particle radiationSupporting apparatusCamera lensLed array
A device for inspecting microscopic objects. A plurality of LEDS is arranged in an array underneath a lens. Some of the LEDS are lighted and some of the LEDS are unlighted. A computer is in control of the LED array. The computer turns on selected LEDS from the array to form the lighted LEDS. Also, the computer turns off selected LEDS from the array to form the unlighted LEDS. The lighted LEDS form a pattern of lighted LEDS underneath the lens. In a preferred embodiment, the lens is connected to a computer controlled camera and the microscopic objects are microscopic crystals. In another preferred embodiment UV LEDS are utilized and illuminate crystals from above. In another preferred embodiment UV LEDS are utilized to illuminate a loop of a Hampton pin to locate a crystal in the loop of a Hampton pin for the purpose of x-ray crystallography.
Owner:RIGAKU AUTOMATION
Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
Owner:CYTONOMEST
Apparatuses and methods for creating and testing pre-formulations and systems for same
InactiveUS6939515B2Shorten the timeReduce riskSequential/parallel process reactionsOrganic chemistry methodsMedicineComputerized system
The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing. Yet another apparatus may be used to crystallize mixtures on a substrate such that the crystallized mixture can be screened by one or more screening devices.
Owner:FREESLATE
Microfluidic protein crystallography techniques
InactiveUS7217321B2Polycrystalline material growthFrom normal temperature solutionsDiffusionCrystalline materials
The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
Owner:CALIFORNIA INST OF TECH +1
Microfluidic protein crystallography techniques
The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.
Owner:CALIFORNIA INST OF TECH +1
Microplate storage apparatus and method
An embodiment of the invention has a side panel with integrated shelving members and integrated locating members, both folded from the side panel. One method of fabricating the shelving members involves cutting a template of the shelving members and locating members onto the side panel and then folding the cut portions of the side panel to form shelving members and locating members.
Owner:KENDRO LAB PRODS
Crystal forming devices and systems and methods for using the same
ActiveUS8105553B2Improve sealingFrom normal temperature solutionsAnalysis by subjecting material to chemical reactionActuatorBiomedical engineering
The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.
Owner:STANDARD BIOTOOLS INC
Laboratory cap and well for hanging-drop crystallization methods
InactiveUS7316805B1Polycrystalline material growthFrom normal temperature solutionsLaboratory facilityCrystallization
The invention relates to a device for molecular and macromolecular crystallization. More particularly, the device comprises a well and a transparent cap for growing diffraction-quality protein crystals by conventional vapor diffusion techniques. The present device is particularly advantageous in that it allows the pre-filling of the well with a solution for transport and handling.
Owner:MOLECULAR DIMENSIONS INC
Array for crystallizing protein, device for crystallizing protein and method of screening protein crystallization using the same
InactiveUS20050075482A1Conveniently and highly efficiently crystallizingConveniently and highly efficiently crystallizing proteinBioreactor/fermenter combinationsSequential/parallel process reactionsMicroarrayProtein crystallization
The present invention relates to a method of precipitating protein crystals from a protein-containing sample. The present invention also relates to a novel microarray and a novel device for screening for protein crystallization condition. Furthermore, the present invention relates to a method of conveniently and quickly screening for protein crystallization conditions using the microarray or the device having highly integrated and held crystallization conditions even with an extremely small quantity of a sample.
Owner:MITSUBISHI RAYON CO LTD
Device and method for high throughput screening of crystallization conditions in a vapor diffusion environment
InactiveUS20090111711A1Enable formationEasy to handlePolycrystalline material growthFrom normal temperature solutionsProtein solutionMicro perforated plate
A high-density high-throughput microplate and methods for simultaneously screening a plurality of protein crystallization solutions and for producing diffraction quality protein crystals in a vapor-diffusion environment are disclosed. The microplate has defined side-by-side paired chambers of equal size, wherein the side-by-side paired chambers have a maximum volume of about 8 μl, and wherein the paired chambers have a vapor channel, therein providing vapor exchange between the side-by-side paired chambers. The microplate further includes a membrane to seal the surface of the microplate. The microplate is adapted to receive a crystallization solution in one of the side-by-side paired chambers and a protein solution in the other of the side-by-side paired chambers, wherein the protein solution and the crystallization solution interact via a vapor diffusion process, which enables the formation of protein crystals within the chamber that contains the protein solution.
Owner:JANSSEN PHARMA NV
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