An adjustable mandibular advancement lateral lying snore-ceasing device comprises a power supply, a sleep monitoring module, a communication control module, a feedback execution module, an upper tooth socket, a lower tooth socket and an external fixator, wherein the power supply, the sleep monitoring module, the communication control module and the feedback execution module are integrated into a fine whole and are mounted in the external fixator of the adjustable mandibular advancement device; the sleep monitoring module comprises an angular displacement sensor, a sound sensor, a respiratory airflow sensor and a blood oxygen pulse sensor; the communication control module is provided with a wireless communication device, is connected with a mobile phone APP terminal and a cloud AI intelligent data platform, and is electrically connected with the feedback execution module; the feedback execution module comprises a driver, a vibrator, an electrical stimulator or a sound stimulator. The technical method of lateral position sleep and mandibular advancement is adopted, intelligent monitoring and regulation are combined, the curative effect is further improved, adverse reactions are reduced, and the device is simple, convenient, practical, safe and effective.