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32 results about "Tissue diagnosis" patented technology

Tissue diagnosis is the diagnosis rendered by a pathologist and is based upon the microscopic examination of a tissue specimen removed during a biopsy/surgical procedure.

Ultrasound guided tissue measurement system

A tissue guidance system integrates an ultrasound imaging device with a tissue diagnostic probe. Ultrasound imaging is used to guide the tissue probe to the target area. Measurements made by the probe can then be analyzed to determine tissue type or state (e.g., malignant or benign).
Owner:BIOTELLIGENT

Device for Tissue Diagnosis and Spatial Tissue Mapping

A miniature electrode array is utilized to stimulate tissue and measure tissue response. When the tissue response is used to diagnose tissue, the spacing of the electrodes in the array is approximately equal to the depth of tissue which is to be examined. The manufacture of such arrays can be accomplished by embedding printed circuit boards, for example, into a properly shaped probe tip. A kinetic device to position the probe on the surface of the tissue provides location information which is correlated with the simultaneous electrical response data in order to generate a tissue map. The tissue mapping capability can be combined with tissue removal devices in order to direct the excision of tissue. When the tissue response is used simply to determine that the array is in contact with the tissue, the electrodes can be widely spaced. Combined with a cell collection device, the electrodes provide feedback to the practitioner that the collection device is making proper contact over the region where cells are to be collected.
Owner:MILLER CRAIG JAMES

Fluid flowing device and method for tissue diagnosis or therapy

A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting / aspirating lumen that can dispense or aspirate a fluid within the tumor, and an outer sheath or guide. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.
Owner:NUVUE THERAPEUTICS

Systems and methods for treating breast tissue

A system for treating breast tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end configured for insertion into a breast duct such that the lumen is in fluid communication with the breast duct, and a tissue diagnostic device disposed within the lumen. A system for treating breast tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end configured for insertion into a breast duct such that the lumen is in fluid communication with the breast duct, an imaging device for providing imaging functionality to the cannula, and an energy delivery device secured to, or slidably disposed within the lumen of, the cannula.
Owner:BOSTON SCI SCIMED INC

Fluid flowing device and method for tissue diagnosis or therapy

ActiveUS20090036823A1Minimizing operator-associated variabilityBroaden applicationElectrotherapyMulti-lumen catheterInjected substanceSolid tumor
A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting / aspirating lumen that can dispense or aspirate a fluid within the tumor. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.
Owner:NUVUE THERAPEUTICS

Magnetic Resonance Imaging For Diagnostic Mapping Of Tissues

Methods of, and systems for, magnetic resonance imaging of diagnostic mapping of tissues, where sodium mapping is performed individually, as well as in combination with other images of tissue, such as T1ρ, T2, and / or T1-weighted images. In one method embodiment, a sodium image of the tissue is acquired during the same scanning session. Maps are constructed of each of the first and sodium images individually, and in combination, and further facilitate viewing in combination with each other as a single, blended image of the tissue. Maps of the images may be displayed individually or in combination with each other.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

Fluid flowing device and method for tissue diagnosis or therapy

A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting / aspirating lumen that can dispense or aspirate a fluid within the tumor, and an outer sheath or guide. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.
Owner:NUVUE THERAPEUTICS

Method and system for rehabilitation of scar tissue

A method using a prior art hand-held device known as the Dolphin Neurostim™ to supply minute, concentrated micro-current impulses to the (outside) perimeters of scar tissue for the purpose of tissue diagnosis (through ohm resistance measurement), promotion of scar tissue repair (through electrical repolarization), and pain management (through sympathetic deregulation of the Autonomic Nervous System. The micro-current stimulus (therapy) is delivered through a tiny metallic spring tip (probe) ideally suited for location (detection) of specific treatment points (which have the cellular characteristic and lowered skin resistance). The device is activated to deliver a concentrated (DC) micro-current stimulus through the scar / suture tissue to another identical device located (mirrored) on the opposing side of the scar / suture. This stimulation reactivates cellular metabolism and membrane exchange, changing scars appearance, softening scar / suture tissue by releasing relating adhesions which re-balances the autonomic nervous system.
Owner:CENT FOR PAIN & STRESS RES

OCT imaging system for integrated optical fiber sensing in-vivo multi-parameter measurement

The invention relates to the technical field of optical fiber sensing medical devices, in particular to an OCT imaging system for integrated optical fiber sensing in-vivo multi-parameter measurement.The OCT imaging system includes a light source module, a first coupler, a first annular device, an interference module, a special-shaped optical fiber microprobe, a photoelectric detector and a balance detector. Two output ports of the first coupler are connected with an input end of the interference module and a port A of the first annular device respectively; the special-shaped optical fiber microprobe is connected with an interference arm of the interference module and a port B of the first annular device through sector-shaped optical fiber bundles separately; the balance detector is connected with the interference module and a data processing module separately, and the photoelectric detector is connected with a port C of the first annular device and the data processing module separately. The OCT imaging system is reasonable in structure, the OCT probe is integrated with an FBG temperature sensing optical grating and an F-P pressure sensing unit, and the temperature, pressure and other parameters of body tissue are measured at the same time. Precise observation of the shape of the tissue and high-resolution large-scale imaging are achieved, and a significant meaning is achievedon in-vivo tissue diagnoses and the like.
Owner:WUHAN UNIV OF TECH

Methods and systems for characterizing tissue of a subject utilizing a machine learning

Methods and systems for characterizing tissue of a subject include acquiring and receiving data for a plurality of time series of fluorescence images, identifying one or more attributes of the data relevant to a clinical characterization of the tissue, and categorizing the data into clusters based on the attributes such that the data in the same cluster are more similar to each other than the data in different clusters, wherein the clusters characterize the tissue. The methods and systems further include receiving data for a subject time series of fluorescence images, associating a respective cluster with each of a plurality of subregions in the subject time series of fluorescence images, and generating a subject spatial map based on the clusters for the plurality of subregions in the subject time series of fluorescence images. The generated spatial maps may then be used as input for tissue diagnostics using supervised machine learning.
Owner:STRYKER EUROPEAN OPERATIONS LIMITED

Whole tissue classifier for histology biopsy slides

Disclosed is a computer implemented method for fully automated tissue diagnosis that trains a region of interest (ROI) classifier in a supervised manner, wherein labels are given only at a tissue level, the training using a multiple-instance learning variant of backpropagation, and trains a tissue classifier that uses the output of the ROI classifier. For a given tissue, the method finds ROIs, extracts feature vectors in each ROI, applies the ROI classifier to each feature vector thereby obtaining a set of probabilities, provides the probabilities to the tissue classifier and outputs a final diagnosis for the whole tissue.
Owner:NEC CORP

Fluid flowing device and method for tissue diagnosis or therapy

A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting / aspirating lumen that can dispense or aspirate a fluid within the tumor. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.
Owner:NUVUE THERAPEUTICS

Magnetic resonance imaging for diagnostic mapping of tissues

Methods of, and systems for, magnetic resonance imaging of diagnostic mapping of tissues, where sodium mapping is performed individually, as well as in combination with other images of tissue, such as T1ρ, T2, and / or T1-weighted images. In one method embodiment, a sodium image of the tissue is acquired during the same scanning session. Maps are constructed of each of the first and sodium images individually, and in combination, and further facilitate viewing in combination with each other as a single, blended image of the tissue. Maps of the images may be displayed individually or in combination with each other.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

Lipid droplet targeting and biological thiol sensitive fluorescent probe for cancer cell tissue diagnosis and preparation and application thereof

The invention relates to a lipid droplet targeting and biological thiol-sensitive fluorescent probe for cancer cell tissue diagnosis and preparation and application thereof, the specific structural formula of the fluorescent probe is as follows: the fluorescent probe has ultrafast response time (Cys / Hcy / GSH is 60s, and Na2S is 240s) to a biological thiol fluorescence signal, meanwhile, the fluorescent probe shows remarkable LDs targeting ability, and the fluorescent probe can be applied to the diagnosis of cancer cells. The compound has been applied to biological mercaptan selective imaging in living cell LDs; more importantly, the probe can be used for distinguishing cancer cells / tissues from normal cells / tissues, and can also be used for diagnosing surgical specimens of cancer patients.
Owner:JILIN INST OF CHEM TECH

Device and method for tissue diagnosis in real-time

A device for real-time tissue diagnosis of biological tissue having: a means for preparing a tissue sample before a measurement procedure; a means for positioning an ATR element and mirrors so as to perform a system calibration; a means for irradiating a sample with IR radiation using the ATR element and an opto-mechanical assembly; a means for recording the absorption spectrum of a sample being tested; a means for carrying out a Fourier transformation of the absorption spectrum obtained into a FT-IR spectrum; a means for calculating tissue characteristics on the basis of signal processing; a means for comparing the characteristics in a pre-selected wavenumber range with the reference spectra prepared and stored in a database. Also, a method for real-time tissue diagnosis of biological tissue having solely the following steps: setting operating parameters: scanning ambient background air to obtain a background spectrum; placing a tissue under test in tight contact with an ATR; drying the tissue so as to at least reduce moisture content of the tissue sample; automatically adjusting at least one system mirror thereby performing a system calibration; and obtaining a spectrum of the tissue sample.
Owner:PIMS PASSIVE IMAGING MEDICAL SYST

Tissue hybridization in situ diagnosis and detection system for BKV and application thereof

The invention relates to the technical field of gene diagnosis, in particular to an in-situ nucleic acid diagnosis and detection system for BKV. The in-situ nucleic acid diagnosis and detection systemcomprises probes used for detecting the BKV, sequences of the probes are the sequences or complementary chains correspondingly shown in SEQ ID NO: 1-40. The invention further discloses application ofthe in-situ nucleic acid diagnosis and detection system to preparation of diagnosis or detection reagents / kits for the BKV. The tissue hybridization in situ diagnosis and detection system for the BKVis high in sensitivity and good in specificity, and can be used for accurately diagnosing the activation of the BKV to guide clinical symptomatic medication, and the sensitivity and specificity of the BKV tissue diagnosis are improved. According to the application of the BKV hybridization in situ technology, the sensitivity and specificity of the BKV tissue diagnosis can be greatly improved, theharm caused by BKV related diseases is reduced, and wide market application prospects are achieved.
Owner:SHANGHAI PUBLIC HEALTH CLINICAL CENT

Method for estimating pathological tissue diagnosis result (gleason score) of prostate cancer

Provided is a method of obtaining an index value used for pathological tissue diagnosis of prostate cancer, which method has low invasiveness and can be performed at a low cost. The method is a method of estimating a Gleason score that represents the malignancy of prostate cancer, which method includes: measuring the content of a prostate-specific antigen having an N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a sample; and estimating that the Gleason score is 7 or higher when the thus measured value is larger than a threshold value, or estimating that the Gleason score is 6 or lower when the measured value is smaller than a threshold value. The prostate-specific antigen is preferably quantified by a method including the step of binding a molecule having an affinity for β-N-acetylgalactosamine residue, such as Wisteria floribunda lectin, soybean agglutinin, Vicia Villosa lectin or an anti-β-N-acetylgalactosamine antibody, to the prostate-specific antigen.
Owner:OTSUKA PHARM CO LTD

Pancreatic cancer detection kit and detection method (PCR method)

PendingCN111961724AEarly diagnosisSolve the problem of late diagnosis cycleMicrobiological testing/measurementTumor vesselOncology
The invention discloses a pancreatic cancer detection kit. The kit comprises a PCR reaction solution, polymerase, a negative control sample and a positive control sample, wherein the PCR reaction solution comprises dNTPs, PCR Buffer, a primer and a probe, the volume and the quantity of the raw materials are 0.96 mL x 2 parts respectively, the polymerase is Taq DNA polymerase, and the volume and the quantity of the raw materials are 85 [mu]l x 1 part respectively. The invention relates to the technical field of gene engineering. According to the pancreatic cancer detection kit and the detectionmethod (PCR method), pancreatic non-cancerous tissue and cancerous tissue can be distinguished through a DNA methylation state, the sensitivity and specificity of cancer tissue diagnosis are both 100%, and it can be found as soon as possible that secreted protein acidic and rich in cysteine (SPARC) of a recurrent patient plays a role in regulating the cell matrix effect and tumor angiogenesis, proliferation and migration. SPARC gene methylation occurs in the early stage of pancreatic cancer, so that detection of SPARC gene methylation is of great significance to early diagnosis of adenocarcinoma.
Owner:HUBEI JIDENGFENG BIOTECH

An oct imaging system for in vivo multi-parameter measurement with integrated optical fiber sensing

The invention relates to the technical field of optical fiber sensing medical devices, in particular to an OCT imaging system for integrated optical fiber sensing in-vivo multi-parameter measurement.The OCT imaging system includes a light source module, a first coupler, a first annular device, an interference module, a special-shaped optical fiber microprobe, a photoelectric detector and a balance detector. Two output ports of the first coupler are connected with an input end of the interference module and a port A of the first annular device respectively; the special-shaped optical fiber microprobe is connected with an interference arm of the interference module and a port B of the first annular device through sector-shaped optical fiber bundles separately; the balance detector is connected with the interference module and a data processing module separately, and the photoelectric detector is connected with a port C of the first annular device and the data processing module separately. The OCT imaging system is reasonable in structure, the OCT probe is integrated with an FBG temperature sensing optical grating and an F-P pressure sensing unit, and the temperature, pressure and other parameters of body tissue are measured at the same time. Precise observation of the shape of the tissue and high-resolution large-scale imaging are achieved, and a significant meaning is achievedon in-vivo tissue diagnoses and the like.
Owner:WUHAN UNIV OF TECH

Application of tuberculosis immunohistochemical kit in diagnosis of tuberculosis pathological tissues

The invention discloses an application of a tuberculosis immunohistochemical kit in diagnosis of tuberculosis pathological tissue (including intrapulmonary and extrapulmonary tuberculosis pathologicaltissues), and belongs to the field of tuberculosis diagnosis. According to the invention, a tuberculosis antigen specific aptamer nucleic acid antibody is adopted, biotin, or fluorescence, chemiluminiscence and the like are adopted for labeling, mycobacterium tuberculosis specific antigen (ManLAM antigen) existing in tuberculosis pathological tissues is detected, and the antigen can exist in thalli and be secreted to the surrounding space; clinical sample immunohistochemistry proves that the tuberculosis antigen specific aptamer antibody is high in staining on tuberculosis infected tissues and low in background staining. The tuberculosis is tuberculosis caused by mycobacterium tuberculosis or drug-resistant mycobacterium tuberculosis (including intrapulmonary tuberculosis and extrapulmonary tuberculosis) and all tuberculosis co-affected by people and livestock. The invention provides a tuberculosis immunohistochemical kit in tuberculosis pathological tissues, and provides a new tool for histopathological definite diagnosis of tuberculosis pathological tissues.
Owner:武汉顺可达生物科技有限公司

Method and system for cranial suture release

A method of using of a pair of prior art hand-held device known as the Dolphin Neurostim™ to supply minute, concentrated micro-current impulses to the perimeters of cranial sutures for the purpose of tissue diagnosis (through ohm resistance measurement), promotion pain management (through sympathetic deregulation of the Autonomic Nervous System. The micro-current stimulus (therapy) is delivered through a tiny metallic spring tip (probe) ideally suited for location (detection) of specific treatment points (which have the cellular characteristic of lowered skin resistance). The device concurrently detects, measures, and stimulates therapeutically active treatment points located beside sutures. Once detected, the device is activated to deliver a concentrated (DC) micro-current stimulus through the suture tissue to another identical device located (mirrored) on the opposing side of the suture. This unique stimulation when applied as described in this invention re-balances the autonomic and central nervous systems.
Owner:CENT FOR PAIN & STRESS RES
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