42 results about "Stress disorders" patented technology

Substituted pyridines, pyrimidines, pyrazines, pyridinones, pyrimidinones, pyrazinones and phenylacetamides useful in treating depression, stress and other disorders are disclosed. The compounds are of the following formulae.

The subject invention concerns materials and methods for treating and / or preventing diseases associated with accumulation of Aβ peptide in neural tissue. The subject invention also concerns materials and methods for treating and / or preventing stress disorders, such as post-traumatic stress disorder (PTSD). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of cotinine, or a pharmaceutically acceptable salt thereof, to a person or animal in need of treatment. The methods of the invention can be used to prevent and / or treat Alzheimer's disease, Parkinson's disease, and / or Down's syndrome. The subject invention also concerns compositions that comprise cotinine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or adjuvant.The subject invention concerns materials and methods for detecting and diagnosing conditions associated with accumulation of Aβ peptide in neural tissue, such as Alzheimer's disease and Parkinson's disease, using the chemical cotinine. In one embodiment, the method comprises administering cotinine labeled with a detectable label to a person or animal. The presence of labeled cotinine in neural tissue is then determined. The level and / or location of cotinine can be analyzed and a diagnosis made. The subject invention also concerns cotinine labeled with a detectable label. In one embodiment, the cotinine is labeled with a radioisotope that can be detected by Positron Emission Tomography (PET) or single photon emission computed tomography (SPECT).

The present invention comprises novel methods for the use of compositions comprising 7-keto DHEA for treating psychiatric conditions. These methods include administering an effective amount of a composition comprising 7-keto DHEA in an acceptable carrier, alone or in combination with other psychiatric drugs, such as analgesic agents, anticonvulsants, anti-anxiety agents, antidepressants, anti-panic agents, antipsychotic agents, bipolar agents, psychostimulants to reduce or ameliorate symptoms of a psychiatric condition. This method may be used alone or as an adjunctive treatment for treating a wide variety of psychiatric conditions such as stress disorders, anxiety disorders and depressive disorders.

The invention discloses application of a small dose of propofol in preparing products for preventing and curing post-traumatic stress disorder (PTSD). Stress disorder and its related diseases include acute stress disorder (ASD) and PTSD. According to the test of injecting a small dose of propofol in the abdominal cavity of a PTSD pattern animal, the small dose of propofol has function of relieving fear, anxiety and learning and memory impairment of the PTSD pattern animal, and can decrease expressions of inducible nitric oxide synthase (iNOS) and neurons nitric oxide synthase (nNOS) which are caused by strong stress, increase expression of brain derived neurotrophic factor (BDNF) which plays an important role in neuroplasticity regulation and reduce release of nitric oxide (NO) of glioma cell of the pattern animal greatly. Accordingly, propofol with the advantages of quick action, quick metabolic clearance and no residues has good application prospect.

The subject invention concerns materials and methods for treating and / or preventing diseases associated with accumulation of Aβ peptide in neural tissue. The subject invention also concerns materials and methods for treating and / or preventing stress disorders, such as post-traumatic stress disorder (PTSD). In one embodiment, a method of the invention comprises administering a therapeutically effective amount of cotinine, or a pharmaceutically acceptable salt thereof, to a person or animal in need of treatment. The methods of the invention can be used to prevent and / or treat Alzheimer's disease and Parkinson's disease. The subject invention also concerns compositions that comprise cotinine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or adjuvant. The subject invention concerns materials and methods for detecting and diagnosing conditions associated with accumulation of Aβ peptide in neural tissue, such as Alzheimer's disease and Parkinson's disease, using the chemical cotinine.

A method for detecting a chemical and a detection device whereby a chemical is captured by a scavenger and thus detected, said scavenger being produced by using a molecular template. The present invention provides a chemical sensor which is easy-to-use not only for medical experts (e.g., medical doctors, clinical technologists and nurses) but also for general domestic consumers. In particular, the present invention addresses the problem of highly sensitively detecting a steroid hormone such as cortisol, said hormone closely relating to a stress disorder, and thus diagnosing the stress disorder in early stage on the basis of the sign to thereby contribute to the prevention and prompt therapy thereof. Provided is a molecular template of a steroid hormone, said molecular template comprising a polymer capable of interacting with the steroid hormone. The polymer preferably contains, per polymer unit, at least two functional groups that are capable of interacting with the steroid hormone.

The invention provides a novel field psychological stress protection system. The system is characterized in that the system comprises a command and control module, a triage rescuing module, a psychological detection module, a psychological stress intervention module and a stress disorder first aid module; the command and control module is respectively connected with the triage rescuing module, thepsychological detection module, the psychological stress intervention module and the stress disorder first aid module to carry out flow management on wounded soldiers, query the information of the wounded soldiers and count the data of the wounded soldiers. The system makes an instant comprehensive injury judgment according to the real-time psychological and physiological state of the rescued personnel to guide classified treatment, and has the advantages of standardized rescuing and curing method, high rescuing and curing efficiency, strong pertinence, and meeting of the rapid, accurate andefficient wartime rescuing and curing requirements. The commander can immediately obtain the individual injury state information of the rescued person and the injury characteristics and types and theflow direction of the wounded soldiers in batches in order to easily make a best command decision.

The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.

The subject invention concerns materials and methods for treating depression, stress disorders, such as PTSD, anxiety disorders, and / or a neurodegenerative disease or condition in a person or animal. In one embodiment, a person or animal in need of treatment is administered one or more compounds or drugs, or a composition comprising the one or more compounds or drugs, that inhibit FKBP51 activity or function. The subject invention also concerns a method for inhibiting activity of the FKBP51 protein in a cell. The subject invention also concerns methods of screening for compounds or drugs that inhibit the FKBP51 protein.

The present invention is concerned with deuterium-enriched pyrimidine compounds of formula 1, their derivatives and pharmaceutically acceptable salts and methods of use thereoffor the prevention and treatment of neuroendocrine neoplasia including metastasis and fibrosis, fibrotic processes associated with neuroendocrine cell dysregulation for example Crohn's disease, pulmonary arterial hypertension, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), right ventricular hypertrophy, pulmonary vascular remodeling, asthma, cystic fibrosis, hypertension, ischemic stroke, angina pectoris, congestive heart failure, arrhythmia, arterial fibrillation, neurodenerative diseases, gastrointestinal disorders , stress disorders, obsessive compulsive disorders, demyelinating diseases, cereberal vascular disorders, bronchoconstriction, vasodilation, smooth muscle contraction, brain disorders, vascular disorders, neuropathological diseases and cardiovascular system regulation.

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicinal composition for preventing or treating military stress disorders and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from lucid ganoderma, lucid ganoderma spore, herba dendrobii, radix ginseng, radix astragali, glossy privet fruits, fructus schisandrae, fermented soybean and dried tangerine or orange peel at a certain ratio. The traditional Chinese medicinal composition has the efficacies of benefiting qi for promoting production of fluid, tonifying the kidney and the spleen, tranquilizing the mind by nourishing the heart, relieving the exterior syndromes and restlessness, dispersing stagnated liver qi to relieve depression, nourishing Yin and suppressing Yang, and improving the body immunity. The pharmacological test proves that the traditional Chinese medicinal composition can obviously improve the behavior abnormality and immunologic function biochemical index change of stress disorder model rats, and has the efficacy of treating both manifestation and root cause of diseases. The clinical verification result shows that the traditional Chinese medicinal composition has the effective prevention and treatment effects for the stress disorders caused by various stimulating factors, and can obviously improve the symptoms including dysphoria and aypnia, willies, melancholy, moodiness, headache and heavy feeling in the brain, loss of appetite, fatigue and indolence, immunity decline, and the like.

A system for generating a stress disorder ration program includes a computing device configured to obtain a stress representation, ascertain an equanimity signature, wherein ascertaining the equanimity signature further comprises retrieving an acclimation element, determining a relative vector as a function of the acclimation element, and ascertaining the equanimity signature as a function of the relative vector and the stress representation using a stress machine-learning model, identify a physiological influence as a function of the equanimity signature, determine an edible as a function of the physiological influence, and generate a ration program as a function of the edible.

Pointing devices such as computer mouse are commonly used for making selections on computer screens. However, prolong or frequent use of such pointing devices might result in users suffering from repetitive stress disorder. Further, due to the widespread use of personal computers (PC), this problem is made more even pronounced. In addition, users increasingly require additional buttons to be provided on the computer mouse for purposes such as PC gaming. Although device manufacturers have started building more buttons on existing computer mice, the buttons are typically not ergonomically positioned. An embodiment of the invention describes an ergonomic input device with multi-programmable buttons.

The invention is composition and methods that restore balance to the stress-related steroidal hormone cascade. Upon co-administration, the compounds of the invention restore balance to the cascade and promote or restore normal function in patients suffering from a disorder having a primary psychological stress component. The compositions include a selected combination of isoflavones, alpha lipoic acid, and L dopamine or a precursor thereof, and are preferably obtained from the natural sources disclosed herein. The uses of the invention include administration of the disclosed compositions to patients suffering from PTSD, fibromyalgia, endometriosis, and other disorders having a common chronic stress component.

The invention discloses application of a small dose of propofol in preparing products for preventing and curing post-traumatic stress disorder (PTSD). Stress disorder and its related diseases include acute stress disorder (ASD) and PTSD. According to the test of injecting a small dose of propofol in the abdominal cavity of a PTSD pattern animal, the small dose of propofol has function of relieving fear, anxiety and learning and memory impairment of the PTSD pattern animal, and can decrease expressions of inducible nitric oxide synthase (iNOS) and neurons nitric oxide synthase (nNOS) which are caused by strong stress, increase expression of brain derived neurotrophic factor (BDNF) which plays an important role in neuroplasticity regulation and reduce release of nitric oxide (NO) of glioma cell of the pattern animal greatly. Accordingly, propofol with the advantages of quick action, quick metabolic clearance and no residues has good application prospect.

The present invention is concerned with deuterium-enriched pyrimidine compounds of formula I, their derivatives and pharmaceutically acceptable salts and methods of use thereof,The compounds of formula I are useful for the prevention and treatment of liver fibrosis and cirrhosis, hepatocellular carcinoma, neuroendrcrine neoplasia including metastasis and fibrosis fibrotic processes associated with neuroendocrine cell dysregulation for example Crohn's disease, pulmonary arterial hypertension, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), right ventricular hypertrophy, pulmonary vascular remodeling, asthma, cystic fibrosis, hypertension, ischemic stroke, angina pectoris, congestive heart failure, arrhythmia, arterial fibrillation, gastrointestinal disorders, anxiety, depression, stress disorders, post-traumatic stress disorder, obsessive compulsive disorders, demyelinating diseases, acute or chronic cerebrovascular damage, cerebral infarction, subarachanoid hemorrhage, and cerebral edema, neuropathological diseases and cardiovascular system regulation.

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicinal composition for preventing or treating military stress disorders and a preparation method of the traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from lucid ganoderma, lucid ganoderma spore, herba dendrobii, radix ginseng, radix astragali, glossy privet fruits, fructus schisandrae, fermented soybean and dried tangerine or orange peel at a certain ratio. The traditional Chinese medicinal composition has the efficacies of benefiting qi for promoting production of fluid, tonifying the kidney and the spleen, tranquilizing the mind by nourishing the heart, relieving the exterior syndromes and restlessness, dispersing stagnated liver qi to relieve depression, nourishing Yin and suppressing Yang, and improving the body immunity. The pharmacological test proves that the traditional Chinese medicinal composition can obviously improve the behavior abnormality and immunologic function biochemical index change of stress disorder model rats, and has the efficacy of treating both manifestation and root cause of diseases. The clinical verification result shows that the traditional Chinese medicinal composition has the effective prevention and treatment effects for the stress disorders caused by various stimulating factors, and can obviously improve the symptoms including dysphoria and aypnia, willies, melancholy, moodiness, headache and heavy feeling in the brain, loss of appetite, fatigue and indolence, immunity decline, and the like.