The invention discloses a novel epidemic prevention detection channel which comprises an inlet gate machine, a temperature detection door, a temperature detection gate machine, a human body disinfection box, a mask pick-up machine and a release gate machine. The inlet gate machine, the temperature detection door, the temperature detection gate machine, the human body disinfection box, the mask pick-up machine and the release gate machine are sequentially connected from front to back. The temperature detection gate machine comprises a first temperature detection gate machine and a manual passage gate machine, the temperature detection door is provided with a camera electrically connected with the temperature detection door, the camera is used for shooting the face of a patient, and the manual passage gate machine is provided with a display screen in communication connection with the camera. Through the arrangement of the temperature detection door, the workload of medical personnel formeasuring the body temperature of patients can be reduced, medical personnel only needs to recheck the patients with abnormal temperature at the manual passage gate machine, the quarantine efficiencyis effectively improved, the efficiency of the patients entering a hospital is improved, and the spread of viruses caused by the fact that a large number of the patients stay at the doorway of the hospital is avoided.