45 results about "Intra-uterine device" patented technology

The present invention relates to an inserter (100), having a proximal (20) and distal (30) end, for inserting and positioning an intra-uterine device (IUD) (120), which is attached to a withdrawal string (130), said inserter (100) comprising: a) a plunger (102), having a central longitudinal axis, configured for slidable mounting of a hollow protective tube (110), the distal (30) end of the plunger (102) being configured for dismountable connection with the IUD (120), which protective tube (110) is configured to slidably cover the IUD (120); b) a handle (104), which is attached to the proximal (20) end of the plunger (102); and c) a longitudinal member (150) that forms part of the handle (104), which extends in the distal (30) direction with respect to the plunger (102), which longitudinal member (150) contains a friction contact surface (152) against which the protective tube (110) can frictionally engage, wherein the frictional engagement of the friction contact surface (152) against the protective tube (110) is manually actuatable and wherein the frictional engagement of the friction contact surface (152) against the protective tube (110) increases resistance to sliding of the protective tube (110) relative to the plunger (102).

The invention relates to a preparation method and application of collagen scaffold composite bone marrow-derived mesenchymal stem cells (BMSCs). The preparation method comprises the steps of preparing single cell suspension after trypsinizing the BMSCs, uniformly dropwise adding the single cell suspension to a collagen scaffold, putting the collagen scaffold into an incubator to be cultured, and adding an L-DMEM complete medium to continue culture, thus obtaining the collagen scaffold composite BMSCs. The preparation method has the advantages that the following defects are overcome: endometria are seriously injured as intrauterine adhesion is mechanically separated by adopting hysteroscopic surgery, intrauterine devices or anti-adhesion materials are put after the surgery and estrogens are given after the surgery to promote intima growth; the problem of intima scars can not be solved; functional intima repair can not be achieved; adhesion is very easy to happen again. As active ingredients for treating serious endometrium injury, the BMSCs are convenient to obtain, secrete growth factors to improve the local microenvironment and immunoregulation, have good biocompatibility, degradability and safety, promote scarred endometrium repair and increase the intima thickness and local blood vessel density.

The present invention discloses an Intra Uterine Ball (IUB) device useful for a gynecological procedure or treatment. The aforesaid device comprises a hollow sleeve for at least partial insertion into the uterine cavity; and, an elongate conformable member with at least a portion comprised of shape memory alloy. The elongate member is adapted to be pushed out from said sleeve within said uterine cavity. It is the core of the invention that the elongate member is adapted to conform into a predetermined three dimensional ball-like configuration within said uterine cavity following its emergence from said sleeve, such that expulsion from said uterine cavity, malposition in said uterine cavity, and perforation of the uterine walls is prevented.

The present invention discloses an Intra Uterine Ball (IUB) device useful for a gynecological procedure or treatment. The aforesaid device comprises a hollow sleeve for at least partial insertion into the uterine cavity; and, an elongate conformable member with at least a portion comprised of shape memory alloy. The elongate member is adapted to be pushed out from said sleeve within said uterine cavity. It is the core of the invention that the elongate member is adapted to conform into a predetermined three dimensional ball-like configuration within said uterine cavity following its emergence from said sleeve, such that expulsion from said uterine cavity, malposition in said uterine cavity, and perforation of the uterine walls is prevented.

The nano composite material for intrauterine birth control device consists of nano metal particle in the content of 0.5-50 wt% and biocompatible polymer. The said nano metal particle is nano copper particle, nano copper particle, nano zinc particle and / or nano silver particle. The nano composite material of the present invention features that the controllable release of the metal ions in some regulation can avoid violent release; and that raising the content in the solution can raise the birth control effect.

An active intra-uterine device (IUD) is prepared from the basic material (low-density polyethene or silicon rubber) and the active substance chosen from steroid hormone contraceptive, Cu particles and copper oxide particles through proportional mixing and blow moulding.

The present invention relates to an inserter (100), having a proximal (20) and distal (30) end, for inserting and positioning an intra-uterine device (IUD) (120), which is attached to a withdrawal string (130), said inserter (100) comprising: a) a plunger (102), having a central longitudinal axis, configured for slidable mounting of a hollow protective tube (110), the distal (30) end of the plunger (102) being configured for dismountable connection with the IUD (120), which protective tube (110) is configured to slidably cover the IUD (120); b) a handle (104), which is attached to the proximal (20) end of the plunger (102); and c) a longitudinal member (150) that forms part of the handle (104), which extends in the distal (30) direction with respect to the plunger (102), which longitudinal member (150) contains a friction contact surface (152) against which the protective tube (110) can frictionally engage, wherein the frictional engagement of the friction contact surface (152) against the protective tube (110) is manually actuatable and wherein the frictional engagement of the friction contact surface (152) against the protective tube (110) increases resistance to sliding of the protective tube (110) relative to the plunger (102).

The invention discloses a partially-degradable composite material for an intrauterine device (IUD). The composite material comprises copper particles, low-density polyethylene and a degradable biological material; the weight of the degradable biological material is 0.5-30% (preferably 5.0-20%) of the total weight of the composite material for the IUD; and the degradable biological material is any one of polylactic acid, polyglycolide and poly (L-lactide). The composite material IUD prepared from the composite material for the IUD has the advantages that on the premise of keeping the Cu<2+> content constant, the Cu<2+> release rate at the early implantation stage can be reduced, the Cu<2+> release rate at the late implantation stage can be improved and the side reactions such as pain and bleeding at the early implantation stage of the composite material IUD prepared from the composite material can be lightened, and the service life of the composite material IUD can be prolonged.

The present invention is directed to intrauterine devices that release progestins or an inflammatory cytokine after placement. These devices can be used to reduce the risk of a woman developing endometrial cancer. The invention is also directed to therapeutic methods in which a sample of uterine cells obtained from a woman is assayed to determine the extent to which PTEN null clones (latent endometrial precancers) are present. In cases where the number of such null clones is high, the woman is administered an intrauterine device that releases either a progestin or an inflammatory cytokine.

The invention discloses a solid reticulate intrauterine device. The intrauterine device is provided with six reticulate faces made of nickel-titanium memory alloy wires; the outer wall of each nickel-titanium memory alloy wire is coated by a silicon rubber layer; and the six reticulate faces are mutually connected to form a cavity inside the intrauterine device. A front reticulate face of the intrauterine device is provided with a similarly triangular frame, the upper end of the frame is a straight side, and the lower end is a small arc side; one end of the straight side is connected with one end of the small arc side through a first long arc side, and the other end of the straight side is connected with the other end of the small arc side through a second long arc side. The shape structure of a rear reticulate face is the same as that of the front reticulate face; and the edge of the front reticulate face and the edge of the rear reticulate face are connected by adopting a plurality of side support ribs to form a left reticulate face, a right reticulate face, an upper reticulate face and a lower reticulate face. The solid reticulate intrauterine device does not need to simultaneously use copper granule release for conception control or carry any medicament, has no toxic side effect for human bodies, can not cause sequela after long-term use, is convenient to place and take out, and causes very slight pain for the human bodies.

The invention relates to the preparation of acellular amniotic membrane carrier combined autologous endometrial stem cells. The isolating culture of autologous endometrial stem cells, the preparationand preservation of acellular amniotic membrane carriers and the preparation of acellular amniotic membrane carrier combined autologous endometrial stem cells are specifically included. The disadvantages of the occurrence of mechanical separation of intrauterine adhesions of hysteroscopic surgery in patients with moderate to severe intrauterine adhesions, the placing of intrauterine devices or anti-adhesion materials after operations, the endometrial functional repair which cannot be realized by giving estrogen to promote endometrial growth after the operations and the easy occurrence of re-adhesion can be overcome. The acellular amniotic membrane carriers have good anti-adhesion abilities, biocompatibility, biodegradability and safety; and as the autologous endometrial stem cells are taken as the active ingredients which can treat severe endometrial injury, growth factors can be secreted to improve local microenvironment and immunoregulation, so that the repair of damaged endometriumcan be promoted, and endometrial thickness and local vascular density can be increased.

The recoverable intra-uterine system comprises a housing capable of containing one or a plurality of elements selected from among the group comprising an embryo, male and / or female gametes, a fertilized oocyte, and unfertilized ovum and a combination of these elements, the housing having along an axis a distal end and a proximal end, and a device for holding the recoverable intra-uterine device in the uterus. The holding device is arranged at the proximal end of the housing and includes at least one holding arm in the uterine cavity capable of taking at least two positions: —one free position in which at least one holding arm is separated from the axis; and —a retracted position in which at least one holding arm is substantially parallel to the axis. Use in medically assisted reproduction techniques.

The present invention relates to an improved intra-uterine contraceptive device (IUCD) characterized by comprising polymer based material 1, and flexible structure 2, wherein the flexible structure 2 comprises one or more of tubelets 3, wherein the tubelets 3 are interconnected by connecting means 4, wherein the tubelets 3 are provided with a pulling means 5 on one end, wherein the tubelets 3 have perforations in the form of holes 6, and wherein the tubelets 3 have both sides 7, 8 open, and said sides are in sloping shape, wherein the tubelets 3 are arranged in the form of a chain, and wherein the combination of said polymer based material 1 and said flexible structure 2 is injectable or implantable in the uterine cavity. In one embodiment it relates to flexible structure referred to as intra-uterine device (IUD).

An everting balloon system is disclosed that can be used for the placement of an IUD within the uterine cavity of a female patient. The everting balloon system with IUD can be used to access a uterine cavity at specific locations in the fundus. A one-handed IUD delivery system for placement with an everting catheter is disclosed. An IUD loading system for placement within an everting catheter is disclosed. The everting catheter with an IUD can simplify the process of IUD placement within the uterine cavity.

An intra-uterine contraceptive device with a shape restoring temp not higher than 36.9 deg.C and an elastic value equal to 0.15-0.75 N is made up of TiNi shape memory alloy and copper through making the parts with TiNi shape memory alloy, making the parts with copper, and assembling.

An everting balloon system is disclosed that can be used for the placement of an IUD within the uterine cavity of a female patient. The everting balloon system with IUD can be used to access a uterine cavity at specific locations in the fundus. A one-handed IUD delivery system for placement with an everting catheter is disclosed. An IUD loading system for placement within an everting catheter is disclosed. The everting catheter with an IUD can simplify the process of IUD placement within the uterine cavity.

The invention belongs to the medical apparatus, and discloses an Intra uterine device place-in apparatus comprising a handle bar formed by a bar portion and a handle portion; a side wall of the front portion of the rod portion is provided with a wire inlet; the rear end of the handle portion is provided with a wire outlet; the wire inlet is connected with the wire outlet through a fixing stay wire channel; a fork head is arranged on the front end of the handle bar, comprises two fork arms, and the front end of the fork arm is provided with a holder slot; two ends of the fixing stay wire respectively turn around two sides of the rear end of the Intra uterine device, the fixing stay wire then enters the fixing stay wire channel through the wire inlet, and exits the wire outlet; a press wire plug inserts the wire outlet so as to tighten and fix two ends of the fixing stay wire; a stay wire guide wire is used for guiding the fixing stay wire. The Intra uterine device place-in apparatus is simple in structure, low in cost, is disposable, safe and clean, convenient and fast in operation, good in applicability, and can be applied to Intra uterine devices of random shapes; the Intra uterine device place-in apparatus can adjust a direction of the Intra uterine device in the uterine cavity, so the Intra uterine device can be placed in a best position, thus ensuring birth control effect.

The invention relates to a medical intrauterine device taking apparatus. The medical intrauterine device taking apparatus comprises a sleeve and a ring taking assembly, the sleeve comprises a round tube part and a tapered tube part protruding at one end of the round cylinder part, and an annular groove is formed in the inner side wall of the tapered tube part; the ring taking assembly comprises afirst cannula and a second cannula, the first cannula is inserted in the sleeve, a spherical rotating body is formed on the end portion of the first cannula and located in the tapered tube part, the periphery of the spherical rotating body is rotatably accommodated in the annular groove, and the a first clamping piece protrudes on the end portion of the spherical rotating body. The medical intrauterine device taking apparatus is used more conveniently.

The invention relates to a recoverable intra-uterine system comprises a housing (1) capable of containing one or a plurality of elements selected from among the group comprising an embryo, male and / or female gametes, a fertilized oocyte, an unfertilized ovum and a combination of these elements, the housing (10) having along an axis (X) a distal end (12) and a proximal end (13), and a device (20) for holding the recoverable intra-uterine device in the uterus. The holding device (20) is arranged at the proximal end (13) of the housing (10) and includes at least one holding arm (23) in the uterine cavity capable of taking at least two positions: - one free position in which at least one holding arm (23) is separated from the axis (X); and - a retracted position in which at least one holding arm (23) is substantially parallel to the axis (X). Use in medically assisted reproduction techniques.

An IUD (intrauterine device) insertion device comprises an insertion tube, a push rod and a handle. The push rod comprises a push rod head, a push rod body and a spring. The spring is arranged between the push rod body and the push rod head. Before insertion of an IUD, the insertion tube of the insertion device can be bent according to the position of uterus so as to adapt to the uterus in shape. When the IUD is conveyed by the push rod having the spring, the push rod can move in correspondence to the shape of the insertion tube while curvature of the insertion tube is prevented from changing due to the rigidity of the insertion tube.

The invention relates to the field of medical instruments, especially relates to an intra uterine device (IUD) removing device, and aims to solve the problem that in the prior art, the one-time success rate and safety of a conventional IUD removing device are low. According to provided technical scheme, the IUD removing device comprises a guide pipe; a support plate is fixed on the middle of the inner side of the guide pipe; a movable connection block is movably connected to the middle of the support plate; the middle of the movable connection block is provided with a through hole; an operating rod is slidingly arranged in the through hole, a connection block is fixedly arranged on the left end of the operating rod, the left side of the connection block is rotatingly connected to two symmetrically arranged groups of IUD removing hooks; the middles of two sides of two groups of IUD removing hooks are provided with connection sheets; and two groups of connection sheets in the same side are connected by springs. The temperature of the guide pipe is controllable, the discomfort feeling for females during the surgery process is relieved, the angle and expansion angle of the IUD removinghooks are controllable, the one-time success rate of IUD removal is increased, moreover, the operation is simple, and the safety is high.

The invention provides an intrauterine device adaptive to various uterine cavities. A body is made of traditional materials such as nickel titanium memory alloy wires, stainless steel wires, metal copper wires, medicine and soft elastic materials like silicone rubber. According to the shape of the body, two longitudinal arms and two horizontal arms are included, the lower ends of the two longitudinal arms are connected in a U shape, the upper ends of the two longitudinal arms are connected with the two horizontal arms to the left side and the right side respectively, and the two ends of the two horizontal arms are designed to be end heads which are made of the soft elastic materials and are of a tooth-shaped structure. According to the design, the suitability of the intrauterine device and a uterine cavity is increased, and intrauterine device displacement and falling off can be effectively avoided.

The invention discloses a visible multi-functional intrauterine contraceptive ring extracting method, comprising the following steps of stretching a contraceptive ring extractor body into the uterus, and injecting normal saline into a one-way valve of a uterus swelling instrument to swell a balloon; observing the intrauterine condition through an endoscope, and finding an intrauterine device or a foreign matter; clamping the target object through a clamping instrument. The invention also discloses a visible multi-functional intrauterine contraceptive ring extractor which comprises the uterus swelling instrument, the endoscope and the clamping instrument, wherein the clamping component of the clamping instrument and the uterus component of the uterus swelling instrument are both arranged on the endoscope. The uterine cavity is enlarged through the uterus swelling instrument, the storage condition of a contraceptive ring in the uterus is observed through the endoscope, the intrauterine device is extracted or the foreign object is cleaned by the clamping instrument, operation can be carried out under the visible condition, the operation time is greatly shortened, the pain of a patient is relieved, the dependence on doctor technology is reduced, the accuracy and success rat of operation can be improved, and in addition, the uterus swelling instrument is a disposable accessory so as to prevent cross infection.

The invention discloses a visible multi-functional intrauterine contraceptive ring extracting method, comprising the following steps of stretching a contraceptive ring extractor body into the uterus, and injecting normal saline into a one-way valve of a uterus swelling instrument to swell a balloon; observing the intrauterine condition through an endoscope, and finding an intrauterine device or a foreign matter; clamping the target object through a clamping instrument. The invention also discloses a visible multi-functional intrauterine contraceptive ring extractor which comprises the uterus swelling instrument, the endoscope and the clamping instrument, wherein the clamping component of the clamping instrument and the uterus component of the uterus swelling instrument are both arranged on the endoscope. The uterine cavity is enlarged through the uterus swelling instrument, the storage condition of a contraceptive ring in the uterus is observed through the endoscope, the intrauterine device is extracted or the foreign object is cleaned by the clamping instrument, operation can be carried out under the visible condition, the operation time is greatly shortened, the pain of a patient is relieved, the dependence on doctor technology is reduced, the accuracy and success rat of operation can be improved, and in addition, the uterus swelling instrument is a disposable accessory so as to prevent cross infection.

A recoverable intra-uterine device comprises a housing (11) containing one or several elements selected from a group containing an embryo, male and / or female gametes, a fertilised oocyte, an unfertilised egg and the combination thereof, wherein said housing (11) is provided with a wall made of a biocompatible material. The wall is provided with a series of perforations (12, 12') whose size is sufficient in order to bring the intra-uterine medium into a cellular contact with the housing (11) and to keep the elements therein. The inventive device is provided with a system for loading and unloding one or several elements selected from the group containing an embryo, male and / or female gametes, a fertilised oocyte, an unfertilised egg and the combination thereof.

An intrauterine device (IUD) for delivering bioactive substances in the uterine cavity includes a plastic frame affixed to a drug delivery compartment. The frame retains the IUD in the uterine cavity and prevents displacement and expulsion. The frame is shaped like the letter “omega” having two resilient arms which possess latero-lateral memory. The extremities of the arms are provided by a short side-arm which forms an angle with the rest of the arm. These prominent plastic parts facilitate the upward rotation of the arms during removal of the intrauterine device. The drug delivery compartment has an element at its upper extremity to determine the exact location of the IUD in the uterine cavity by ultrasound. The drug delivery compartment contains one or more drugs which are gradually released in the uterine cavity over extended periods of time.

The invention discloses an intrauterine device for rats, a placer for the intrauterine device and a manufacturing method for noninvasive type contraceptive rat models with the intrauterine device. The intrauterine device comprises a copper wire part, wherein the front end of the copper wire part is connected with a wire ring made of silk threads; and the rear end of the copper wire part is connected with a traction silk thread. The placer comprises a push core, wherein a fork head is arranged at the head end of the push core; a handle is arranged at the tail end of the push core; the fork head is formed by separating head ends of two fork legs and connecting tail ends of the two fork legs; the head end of each fork leg has a needle point shape; the inner diameter of a rigid outer casing is greater than the width of the widest part formed by separating the two fork legs and the outer diameter of the push core; and the length of the rigid outer casing is smaller than that of the push core. According to the preparation method for the rat models, the intrauterine device for the rats and the placer for the intrauterine device are adopted, so that the rats are not required to receive an open surgery, the intrauterine device is placed through the way of cervix-intrauterine, the contraceptive rat models with intrauterine device, which is in accordance with the clinical contraceptive method through the intrauterine device, are prepared; and the manufacturing method is easy and convenient to operate, the risk is low, and the efficiency is high.

The invention discloses an adjustable intrauterine device. The adjustable intrauterine device comprises an intrauterine device handle, wherein the intrauterine device handle comprises a sector-shaped part, a length regulating part and a connection part, a semicircular plate is arranged at the upper part of the sector part, sector clamping grooves are formed in the two sides of the semicircular plate, an inverted triangle support body is arranged at the upper part of the sector part, the length regulating part is arranged at the lower part of the sector part, and the connection part provided with an external screw thread is arranged at the lower part of the length regulating part. The adjustable intrauterine device disclosed by the invention is simple in structure, low in production and usage cost, different parameters can be regulated according to the actual situations of different individuals, the aims of customization for each individual is realized, application range and adaptation accuracy of the intrauterine device are greatly improved, effect is good, good contraception effect can be achieved, and the harm to a human body also can be reduced; therefore, the adjustable intrauterine device disclosed by the invention has good market potential.

The invention discloses a safe open intrauterine device provided with a bracket of which the left and right shapes are symmetrical, wherein the bracket is an annular body with an opening at the upper part, a cupriferous strip attachment is respectively fixed at two open ends of the bracket, and a U-shaped supporting split ring is formed locally below the bracket. The open intrauterine device is characterized in that the overhung ends of the two cupriferous attachments are oppositely arranged and are both inclined and extended upward in the bracket, an included acute angle between the extension line of the overhung end of each cupriferous attachment and the horizontal line is 0-20 degrees; and the minimum radius of curvature of the U-shaped supporting split ring is 1.5-1.6mm. The special inclination angle of the open intrauterine device can reduce the occurrence rate of incarceration in use, thus furthest reducing the injury of the uterus caused by the overhung ends of the cupriferous attachments.

The invention discloses an intrauterine device fixing device. The intrauterine device fixing device comprises a collagen fixing base and a collagen fixing line. The upper portion of the collagen fixing base is provided with a collagen fixing leg, and the lower portion of the collagen fixing base is provided with a fixing hole. One end of the collagen fixing line is fixed in the fixing hole, and the other end of the collagen fixing line is provided with a collagen connecting ring connected with the upper end of an intrauterine device, and the upper portion of the collagen connecting ring is open. The intrauterine device fixing device overcomes the defects that an existing intrauterine device is prone to moving downwards and disengaging and a puerpera bleeds and pains. The intrauterine device fixing device is fixed in the uterus and is prevented from moving downwards and disengaging, and the puerpera cannot bleed and pain.