The invention discloses an implantable drug-supplying device of a check valve seal-free pipe. The implantable drug-supplying device comprises a drug-supplying device body, wherein the drug-supplying device body is connected with a guide pipe through a locking device and comprises a pump seat, the upper end of the pump seat is provided with a puncture diaphragm, and the upper end of the puncture diaphragm is provided with a pump cover; the pump cover, the puncture diaphragm and the pump seat are hermetically connected, the pump seat is connected with a check valve, and a pump cavity is formed among the pump cover, the puncture diaphragm, the pump seat and the check valve. The implantable drug-supplying device provided by the invention has the beneficial effects that a medicine in an artery pump can directly enter a set part to realize targeted therapy, therefore the curative effect that the killability of pathological cells can be improved by about four times when 1 point of the concentration of the medicines on a focus par is improved; furthermore, the medicine can be effectively prevented from refluxing to block the guide pipe, therefore the operation of needing a heparin sealing water pipe can be prevented after the medicine is injected by the patient by medical personnel, and the practiclaity of the device can be effectively improved.