The invention discloses a preparation process of a honeycomb catalyst for coal-fired flue gas denitration in a thermal power plant as well as the product and application of the preparation process. According to the preparation process, TiO2, WO3, a catalytic addictive and V2O5 are taken as effective components, glass fibers, an organic binding agent, an inorganic binding agent, a pore-forming agent, a neutralizer and a solvent are added, and the honeycomb catalyst is prepared by mixing, kneading, carrying out extrusion molding, drying and firing. According to the preparation process, a wet green body is obtaining by adding the binding agents for modifying the glass fibers, adding the specific catalytic addictive, sequentially adding the other additives, adding a filter screen with a specific specification for filtering strips, carrying out extrusion molding and evenly mixing; the wet green body is treated by a drying process for twice, so that the large-size wet green body is enabled to be uniformly dried and does not easily crack; finally, the honeycomb catalyst is obtained by calcining. The honeycomb catalyst is high in compression strength, and the catalytic denitration rate ofthe honeycomb catalyst is greater than 80%.