The invention discloses a protection mattress with constant temperature for area burnt patients, which includes a mattress, a make-up groove, a spongy cushion, a placement groove, a placement box, anexhaust hole, an exhaust tube, a temperature sensor, a ventilator and a magnetic valve. The protection mattress with constant temperature for area burnt patients is subtle in design, powerful in function and simple in operation. With the protection mattress with constant temperature for area burnt patients, not only does the burnt area on the back of a patient maintain isolated, but also is cooling treatment applied to the burnt area on the back of a patient. Therefore, the burnt area on the back of a patient can maintain constant temperature. In addition, the protection mattress with constanttemperature for area burnt patients can control the temperature of the burnt area on the back of a patient. When the temperature is relatively low, the protection mattress with constant temperature for area burnt patients can blow the cool air in the burnt area on the back of the patient out of his or her body. When the temperature is relatively high, the protection mattress with constant temperature for area burnt patients can inform health care staff of changing ice bags and help them to ensure that the burnt area on the back of a patient maintains constant temperature.