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Zinc-based alloy membrane for guided bone tissue regeneration

A technology for bone tissue regeneration and membrane regeneration, which is applied in the field of oral GTR/GBR membrane materials, can solve the problems of too fast degradation of barrier membrane absorbable collagen membrane, poor mechanical strength, non-degradable barrier membrane, etc., and achieve good cell compatibility and tissue compatibility, reduce production costs, and promote bone regeneration

Pending Publication Date: 2019-06-07
PEKING UNIV SCHOOL OF STOMATOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem of secondary operation of non-degradable barrier membrane in the existing barrier membrane and the problem of fast degradation of absorbable collagen membrane and poor mechanical strength, this application provides a zinc-based alloy guided bone tissue regeneration membrane

Method used

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  • Zinc-based alloy membrane for guided bone tissue regeneration
  • Zinc-based alloy membrane for guided bone tissue regeneration
  • Zinc-based alloy membrane for guided bone tissue regeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Preparation of zinc-based alloy barrier films with different apertures

[0037] 1) Select the original zinc-based alloy to make a 30 μm thick barrier film;

[0038] 2) Step 1) The membrane material is ultrasonically cleaned with acetone, absolute ethanol and deionized water for 15 minutes in sequence, and dried at 25° C.;

[0039] 3) A laser drilling process is used to prepare holes with a diameter of 300 μm and a hole spacing of 1.2 mm on the zinc-based alloy barrier film material treated in step 2).

Embodiment 2

[0040] Embodiment 2, zinc-based alloy barrier film corrosion performance test

[0041] The two zinc-based alloy barrier films prepared in Example 1 were cut to a size of 10×10×0.03 mm, ultrasonically cleaned in acetone, absolute ethanol and deionized water for 15 minutes, and then dried at 25° C. After soaking in Hank's simulated body fluid (NaCl 8.0g, CaCl 2 0.14g, KCl 0.4g, NaHCO 3 0.35g, glucose 1.0g, MgCl 2 ·6H 2 O 0.1g, Na 2 HPO 4 2H 2 O 0.06g, KH 2 PO 4 0.06g, MgSO4 7H 2 (0.06g, be dissolved in 1L deionized water), take out after soaking different time intervals, observe the sample surface, figure 1 These are scanning electron micrographs of non-porous zinc-based alloys soaked in Hank's simulated body fluid for 3, 7, 14, 21, 28, and 60 days respectively. The results show that the surface of the sample remains intact, and with the extension of immersion time, a large amount of surface deposits Hydroxyapatite minerals indicate that zinc-based alloy barrier mem...

Embodiment 3

[0043] Example 3, in vitro cytocompatibility experiment of zinc-based alloy barrier membrane

[0044] According to the method described in Example 2, zinc-based alloy barrier film samples of corresponding sizes and specifications were prepared. The titanium film was used as the control group, sterilized by gamma rays, placed in a sterile culture bottle, and measured according to the surface area of ​​the sample and α-MEM The cell culture medium volume ratio is 1.25cm 2 / mL ratio into α-MEM cell culture medium, placed at 37 ° C, 95% relative humidity, 5% CO 2 After 72 hours in the incubator, the original solution of the zinc-based alloy barrier membrane leaching solution was obtained, sealed, and stored in a refrigerator at 4°C for later use.

[0045] Extraction solution, cell inoculation culture and result observation: MC3T3-E1 cells were resuscitated and passaged, suspended in α-MEM cell culture medium, seeded on 96-well culture plates, so that the final cell concentration was...

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Abstract

The invention relates to a membrane for guided bone tissue regeneration. The membrane is made of pure zinc or zinc alloy. The mechanical property and degradation property of the zinc-based alloy barrier membrane are superior to that of traditional GTR / GBR membrane, and the zinc-based alloy barrier membrane can avoid the disappearance of the barrier effect caused by the membrane collapse in the bone defect area. Both the performance and price of the zinc-based alloy barrier membrane are superior to that of the GTR / GBR membrane in present clinical use, and the zinc-based alloy barrier membranehas no immunogenicity, can maintain good mechanical support after being implanted for a period of time, and has degradability at the same time. The released zinc ions can promote bone regeneration, and improve the quality and the speed of bone regeneration. The zinc-based alloy barrier membrane prepared by the invention has good cell compatibility and tissue compatibility.

Description

technical field [0001] The invention relates to an oral GTR / GBR membrane material, in particular to an oral GTR or GBR membrane made of a zinc-based alloy, which can be used in guided bone regeneration operations. Background technique [0002] Implant restoration has gradually become the preferred restoration method for missing teeth due to its good chewing function, comfort and aesthetic effect. Implant restoration requires the patient to have sufficient bone quality and bone mass. However, the alveolar bone in the implant area caused by trauma, tumor resection, and inflammation is severely insufficient, resulting in the inability to implant the implant or the failure of the implant restoration. Restoring the alveolar bone tissue in the bone defect area and improving the long-term success rate of implant restoration is an urgent problem to be solved in clinical oral treatment. Guided bone regeneration (GBR) is one of the effective methods to solve this problem. [0003] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/04A61L27/28A61L27/32A61L27/34A61L27/54
Inventor 刘云松郑玉峰夏丹丹郭辉王思仪
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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