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Method for constructing implant active surface with high-content BMP/RGD coating

A construction method and active surface technology, which is applied in the construction field of implant active surfaces, can solve the problems of difficulty in fully exerting biological activity, poor long-term stability effect, and low BMP adsorption amount, etc., to improve roughness and surface energy, enhance Active, adhesion-promoting effect

Inactive Publication Date: 2017-05-31
DALIAN SANSHENG SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many studies on the introduction of BMP into the implant surface as a bioactive molecule. Generally, it is fixed on the implant surface by physical adsorption, chemical combination, or physical fixation after being miscible with a biocompatible polymer carrier material. BMP has a small amount of adsorption and is quickly released or absorbed and degraded in a short period of time under physiological conditions, so it cannot play a role of continuous stimulation and induction of osteogenesis in the local area, and its biological activity is difficult to be fully exerted
There are also problems such as low bonding strength with the carrier or implant matrix, poor long-term stability effect and easy falling off during application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The implant active surface with high content BMP / RGD coating was prepared as follows:

[0029] (1) The surface of the titanium metal implant was polished step by step with 200, 300, 600 and 2000 mesh sandpaper, cleaned, and dried at 60°C;

[0030] (2) Use 75μm TiO 2 Particles, sandblasting the surface of the implant through a nozzle, the sandblasting conditions are: the compressed air pressure is 0.3-0.4MPa, the distance between the nozzle and the implant surface is 5cm, and the spraying time is 2s;

[0031] (3) Place the sandblasted implant in a mixed acid etchant composed of hydrofluoric acid and hydrochloric acid for surface etching treatment. The etching treatment temperature is 60°C, and the etching treatment time is 10 minutes. The implant is taken out and ultrasonically Clean and dry naturally at room temperature; wherein the mixed etching agent is a mixture of 47% HF and 38% HCl in a volume ratio of 1:1;

[0032] (4) Incubate the dried implant at 60°C in a 5mo...

Embodiment 2

[0039]The implant active surface with high content BMP / RGD coating was prepared as follows:

[0040] (1) The surface of the titanium metal implant was polished step by step with 200, 300, 600 and 2000 mesh sandpaper, cleaned, and dried at 60°C;

[0041] (2) Use 75μm TiO 2 Particles, sandblasting the surface of the implant through a nozzle, the sandblasting conditions are: the compressed air pressure is 0.3-0.4MPa, the distance between the nozzle and the implant surface is 8cm, and the spraying time is 10s;

[0042] (3) Place the sandblasted implant in a mixed acid etchant composed of hydrofluoric acid and hydrochloric acid for surface etching treatment. The etching treatment temperature is 60°C, and the etching treatment time is 10 minutes. The implant is taken out and ultrasonically Clean and dry naturally at room temperature; wherein the mixed etching agent is a mixture of 47% HF and 38% HCl in a volume ratio of 1:1;

[0043] (4) Incubate the implant after surface etching ...

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PUM

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Abstract

The invention discloses a method for constructing an implant active surface with a high-content BMP / RGD coating. According to the method, a porous rough surface covered with titanium hydroxy is prepared through a surface treatment method combined with abrasive blasting, acid etching and alkali heat treatment processes, an I-type collagen / BMP-2 composite coating with positive charges and an HA / RGD coating with negative charges are alternately and repeatedly introduced on the porous rough surface so as to form multiple layers of molecular coatings which are arranged sequentially, the load capacity of BMP and RGD in the coatings are greatly improved, the coatings are formed mainly dependent on electrostatic attraction between positive ions and negative ions, the stability of BMP and RGD in the coatings is high, the implant after implanted is slowly and continuously released along with degradation of each coating, and the adhesion, proliferation and differentiation of cells, ossification and early bone healing of the implant and peripheral bone tissues are promoted.

Description

technical field [0001] The invention belongs to the field of biomedical implants, and in particular relates to a method for constructing an active surface of an implant with a high-content BMP / RGD coating. Background technique [0002] Titanium metal has the advantages of good biocompatibility, mechanical properties and machining potential, and is currently widely used as a dental implant material in stomatology. However, titanium itself is biologically inert, and after being implanted into the body, it causes problems such as long healing time, low biological activity, and poor ability to induce bone repair. In order to improve its biological activity, plasma spraying, ion sputtering, electrophoresis, microwave sintering and other technologies are currently used to modify the microscopic physical morphology and chemical composition of the implant surface to form a rough porous surface with better biocompatibility and improve However, this type of implant is still physicall...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06A61L27/50A61L27/54
CPCA61L27/34A61L27/06A61L27/50A61L27/54A61L2300/252A61L2300/412A61L2300/602A61L2420/08
Inventor 闫澍张久文蔡俊江彭鹏李闪
Owner DALIAN SANSHENG SCI & TECH DEV
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