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Implant with high-content and high-stability BMP coating

A high-stability, implant technology, used in coatings, dental implants, prostheses, etc., can solve the problems of difficult to fully exert biological activity, poor long-term stabilization effect, and low BMP adsorption, and achieves the promotion of osteogenesis, The effect of improving the degree of bonding and promoting early bone healing

Inactive Publication Date: 2017-05-31
DALIAN SANSHENG SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many studies on the introduction of BMP into the implant surface as a bioactive molecule. Generally, it is fixed on the implant surface by physical adsorption, chemical combination, or physical fixation after being miscible with a biocompatible polymer carrier material. BMP has a small amount of adsorption and is quickly released or absorbed and degraded in a short period of time under physiological conditions, so it cannot play a role of continuous stimulation and induction of osteogenesis in the local area, and its biological activity is difficult to be fully exerted
There are also problems such as low bonding strength with the carrier or implant matrix, poor long-term stability effect and easy falling off during application.

Method used

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  • Implant with high-content and high-stability BMP coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An implant with high content and high stability BMP active surface coating, the active surface coating is prepared according to the following method:

[0031] (1) The surface of the titanium metal implant was polished step by step with 200, 300, 600 and 2000 mesh sandpaper, cleaned, and dried at 60°C;

[0032] (2) Use 75μm TiO 2 Particles, sandblasting the surface of the implant through a nozzle, the sandblasting conditions are: the compressed air pressure is 0.3-0.4MPa, the distance between the nozzle and the implant surface is 5cm, and the spraying time is 2s;

[0033] (3) Place the implant in a mixed acid etchant composed of hydrofluoric acid and hydrochloric acid for surface etching treatment. The etching treatment temperature is 60°C, and the etching treatment time is 10 minutes. The implant is taken out and ultrasonically cleaned, and dried naturally at room temperature ; Wherein the mixed etching agent is a mixture of 47% HF and 38% HCl in a volume ratio of 1:1;...

Embodiment 2

[0041] An implant with high content and high stability BMP active surface coating, the active surface coating is prepared according to the following method:

[0042] (1) The surface of the titanium metal implant was polished step by step with 200, 300, 600 and 2000 mesh sandpaper, cleaned, and dried at 60°C;

[0043] (2) Use 75μm TiO 2 Particles, sandblasting the surface of the implant through a nozzle, the sandblasting conditions are: the compressed air pressure is 0.3-0.4MPa, the distance between the nozzle and the implant surface is 8cm, and the spraying time is 10s;

[0044] (3) Place the implant in a mixed acid etchant composed of hydrofluoric acid and hydrochloric acid for surface etching treatment. The etching treatment temperature is 60°C, and the etching treatment time is 10 minutes. The implant is taken out and ultrasonically cleaned, and dried naturally at room temperature ; Wherein the mixed etching agent is a mixture of 47% HF and 38% HCl in a volume ratio of 1:1...

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Abstract

The invention discloses an implant with a high-content and high-stability BMP active surface coating. A titanium dioxide base layer is arranged on the surface of a titanium-based bottom layer of the implant, and the outer surface of the base layer is alternatively coated by an I type collagen / BMP complex coating with positive charges and an HA coating with negative charges. According the implant with the high-content and high-stability BMP active surface coating disclosed by the invention, a porous coarse surface coated by titanium hydroxyl base is prepared through a surface processing method that a sand blasting technology, an acid etching technology and an alkali heat processing technology are combined; the I type collagen / BMP-2 complex coating with the positive charges and the HA coating with the negative charges are alternatively introduced to the surface repeatedly; thus, load capacity and stability of BMP in the coating are remarkably improved, the BMP can be slowly and continuously released along with degradation of the coating after the implant is implanted into a body, bone formation is promoted, and early bone healing between the implant and peripheral bone tissues is improved.

Description

technical field [0001] The invention belongs to the field of biomedical implants, in particular to an implant with a high-content and high-stability BMP coating and a preparation method thereof. Background technique [0002] Titanium metal has the advantages of good biocompatibility, mechanical properties and machining potential, and is currently widely used as a dental implant material in stomatology. However, titanium itself is biologically inert, and after being implanted into the body, it causes problems such as long healing time, low biological activity, and poor ability to induce bone repair. In order to improve its biological activity, plasma spraying, ion sputtering, electrophoresis, microwave sintering and other technologies are currently used to modify the microscopic physical morphology and chemical composition of the implant surface to form a rough porous surface with better biocompatibility and improve However, this type of implant is still physically combined ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61C8/00A61L27/34A61L27/30A61L27/50A61L27/54
CPCA61C8/0022A61C8/0013A61C8/0016A61C8/0037A61C2201/00A61L27/306A61L27/34A61L27/50A61L27/54A61L2300/414A61L2420/02A61L2420/04A61L2430/12C08L5/08C08L89/00
Inventor 邢文忠张久文付雪松蔡俊江彭鹏李闪
Owner DALIAN SANSHENG SCI & TECH DEV
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