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Compound preparation for treating broiler proventriculitis

A compound preparation and a technology for gland gastritis, which is applied in the field of compound preparations for treating broiler gland gastritis, can solve problems such as endangering human health and potential food safety hazards, and achieve the effects of low production cost, strong product controllability and simple operation.

Inactive Publication Date: 2015-07-15
SHENYANG VICA ANIMAL HUSBANDRY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large amount of antibiotics left in animal products poses food safety hazards and seriously endangers human health

Method used

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  • Compound preparation for treating broiler proventriculitis
  • Compound preparation for treating broiler proventriculitis
  • Compound preparation for treating broiler proventriculitis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0013] Preparation method: Add the prescribed amount of medicine and fillers into a V-type mixer and mix well, and then use a large ultrafine pulverizer to pulverize the uniformly mixed medicine powder, so that more than 90% of the original powder particle size is below 50 μm, and no particle greater than 75 μm particle. Inspection after crushing.

[0014] The quality standards are as follows:

[0015] Properties: ①This product is brown-yellow micro-powder; ②There are no particles larger than 75μm in microscopic examination.

[0016] Identification: ① Dissolve 0.1g of this product in 10ml of water, then add 0.5ml of 3% phosphotungstic acid solution to form a white milky precipitate; A few drops of 10% thiourea solution will produce dark yellow;

[0017] Inspection: ① The weight loss of the sample to be inspected is less than 5% on drying at 105°C;

[0018] Content determination: ① Take an appropriate amount of this product, weigh it accurately, add 50ml of ethanol-water (4...

example 2

[0020] The quality standards are as follows:

[0021] Properties: ①This product is brown-yellow micro-powder; ②There are no particles larger than 75μm in microscopic examination.

[0022] Identification: ① Dissolve 0.1g of this product in 10ml of water, then add 0.5ml of 3% phosphotungstic acid solution to form a white milky precipitate; A few drops of 10% thiourea solution will produce dark yellow;

[0023] Inspection: ① The weight loss of the sample to be inspected is less than 5% on drying at 105°C;

[0024] Content determination: according to high performance liquid chromatography, chromatographic conditions and system suitability Chromatographic column: octadecylsilane bonded silica gel as filler, particle size 5μm, specification: 150mm×4.6mm; mobile phase: acetonitrile-water-three Ethylamine (30:70:0.5) (adjust the pH value to 7.0 with phosphoric acid); mixed solvent: acetonitrile-water-triethylamine (30:70:0.5) (adjust the pH value to 10.0 with phosphoric acid); flow ...

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Abstract

The invention discloses a compound preparation for treating broiler proventriculitis. The compound preparation comprises 1-5wt% of a proton pump inhibitor, 5-30wt% of vitamin U, 3-15wt% of colloidal bismuth pectin and 50-91wt% of a filler. The composition of the compound preparation is screened and optimized, medicines have very good synergistic effects, and the compound preparation has the advantages of low medicine cost, simple production technology and controllable quality. The clinic effective rate of the compound preparation to proventriculitis initiated by feed replacement, moldiness and environment stress reaches above 94%, the clinic cure rate of one treatment course reaches 90%, the compound preparation has an obviously better clinic effect than the single proton pump inhibitor, the treatment course of the compound preparation is shortened to 3d from that of the proton pump inhibitor of 5-7d, the clinic effective rate increases by 6%, and the cure rate increases by 18%. The compound preparation can be used as a combined medicine for treating broiler proventriculitis initiated by virus or bacterium infection, helps broiler flocks recover stomach and intestine digestion functions, and rapidly recovers the feed intake.

Description

technical field [0001] The invention belongs to the field of veterinary medicine preparations. Specifically relates to a compound preparation for treating broiler glandular gastritis. Background technique [0002] Proton pump inhibitors have antacid and antiulcer effects. It can selectively act on the parietal cells of the gastric mucosa, inhibiting H on the secretory microtubules formed by the apical membrane of the gastric parietal cells and the tubular vesicles in the cytoplasm + -K + -ATPase activity, thereby effectively inhibiting the secretion of gastric acid, with rapid onset, suitable for gastric and duodenal ulcers. due to H + -K + -ATPase is the last process of parietal cell acid secretion, so this class of drugs has a strong ability to suppress acid, and has a strong and long-lasting effect of inhibiting basic gastric acid and gastric acid secretion caused by food and pentaglandin. It can not only non-competitively inhibit gastric acid secretion caused by ga...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K33/24A61K31/4439A61P1/00A61P31/04A61P31/12A61K31/198
Inventor 许丹
Owner SHENYANG VICA ANIMAL HUSBANDRY TECH
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