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Preparation method of degradable magnesium alloy/modified polylactic acid coating composite material

A composite material and magnesium alloy technology, which is applied in the field of preparation of degradable magnesium alloy/modified polylactic acid coating composite materials, can solve the problems of low molecular weight, fast degradation speed and high preparation cost of polylactic acid, and achieve the goal of reducing degradation rate, Good for blocking body fluids and improving corrosion resistance

Inactive Publication Date: 2016-03-02
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The coating adopts a composite coating, the structure is relatively complex, and the preparation cost is high, and the molecular weight of polylactic acid in this patent is low, and the degradation speed is very fast

Method used

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  • Preparation method of degradable magnesium alloy/modified polylactic acid coating composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Simple pretreatment of the substrate: Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water Ultrasonic cleaning with anhydrous ethanol for 10 minutes, and drying at room temperature for later use;

[0030] (2) Acid etching pretreatment: place the magnesium alloy substrate obtained by simple pretreatment in 90% (v%) phosphoric acid solution at 55°C for acid etching treatment for 30s, then place it in 1M NaOH solution for neutralization treatment for 90s, and then place it in distilled water Wash in medium for about 30s and dry for later use.

[0031] (3) Configuration of polylactic acid solution: Dissolve 10 g of PLA with a weight average molecular weight of 2 million in 200 ml of chloroform solvent, and magnetically stir to make it dissolve evenly.

[0032] (4) Prepar...

Embodiment 2

[0036](1) Simple pretreatment of the substrate: Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water Ultrasonic cleaning with anhydrous ethanol for 10 minutes, and drying at room temperature for later use;

[0037] (2) Acid etching pretreatment: place the magnesium alloy substrate obtained by simple pretreatment in 90% (v%) phosphoric acid solution at 55°C for acid etching treatment for 30s, then place it in 1M NaOH solution for neutralization treatment for 90s, and then place it in distilled water Wash in medium for about 30s and dry for later use.

[0038] (3) Configuration of polylactic acid solution: Dissolve 10 g of PLA with a weight-average molecular weight of 4 million in 200 ml of chloroform solvent, and magnetically stir to make it dissolve evenly.

[0039] (4) Prepara...

Embodiment 3

[0043] (1) Simple pretreatment of the substrate: Cut the ZK60 magnesium alloy into moderate-sized samples with a wire cutting machine, and then polish them with 800# and 2000# alumina water-resistant sandpaper to remove the oxide layer on the surface of the magnesium alloy, and then use deionized water Ultrasonic cleaning with anhydrous ethanol for 10 minutes, and drying at room temperature for later use;

[0044] (2) Acid etching pretreatment: place the magnesium alloy substrate obtained by simple pretreatment in 90% (v%) phosphoric acid solution at 55°C for acid etching treatment for 40 seconds, then place it in 1M NaOH solution for neutralization treatment for 2 minutes, and then place it in distilled water Wash in medium for about 30s and dry for later use.

[0045] (3) Configuration of polylactic acid solution: Dissolve 5 g of PLA with a weight average molecular weight of 2 million in 200 ml of chloroform solvent, and perform magnetic stirring to make it dissolve evenly. ...

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Abstract

The invention relates to a method for preparing a degradable magnesium alloy and modified polylactic acid coating composite material. The method includes the following steps that a magnesium alloy matrix is polished so that a surface oxidization layer is removed; acid etching pre-treatment and neutralizing treatment are carried out on the magnesium alloy matrix; polylactic acid is dissolved in a chloroform solution and a polylactic acid solution is prepared; the magnesium alloy matrix is immersed in the polylactic acid solution, and the surface of the magnesium alloy matrix is wrapped with a polylactic acid coating in a solution immersing and coating method; the obtained magnesium alloy material wrapped with the polylactic acid is stored for 2-3 days in a ventilated place, so that chloroform in the polylactic acid solution is volatilized completely, and the degradable magnesium alloy and modified polylactic acid coating composite material is obtained. Compared with the prior art, the anti-corrosion performance of ZK60 magnesium alloy can be improved obviously through the obtained magnesium alloy and modified polylactic acid coating composite material, the degradation rate of the ZK60 magnesium alloy in an organism can be greatly reduced, and researching and application of the ZK60 magnesium alloy in the medical field are promoted.

Description

technical field [0001] The invention relates to a preparation method of a composite biological material, in particular to a preparation method of a degradable magnesium alloy / modified polylactic acid coating composite material. Background technique [0002] Biometal materials currently used in clinic mainly include stainless steel, cobalt-chromium alloy and titanium alloy, etc. These metal materials have good corrosion resistance, good comprehensive mechanical properties and processing properties, but as biologically inert materials, their Poor resistance, lack of osteoinductivity, easy to produce toxic ions harmful to the physiological environment due to friction and slight degradation after implantation in the body, and the elastic modulus is too large, poor mechanical adaptability, easy to cause stress concentration and loosening, falling off . In addition, if such materials are used as short-term implant materials, since they cannot be degraded in the body, after the re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B05D7/14B05D7/24B05D3/10
Inventor 陆伟黄平凌敏贾敏
Owner TONGJI UNIV
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